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5.3.99.3: prostaglandin-E synthase

This is an abbreviated version!
For detailed information about prostaglandin-E synthase, go to the full flat file.

Word Map on EC 5.3.99.3

Reaction

(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate
=
(13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate

Synonyms

CPGES, cPGES/p23, cytosolic prostaglandin E synthase, cytosolic prostaglandin E(2) synthase, cytosolic prostaglandin E(2) synthase-2, endoperoxide isomerase, Isomerase, prostaglandin R2 E-, membrane-associated PGE2 synthase, membrane-associated prostaglandin E synthase-2, membrane-associated prostaglandin E(2) synthase-1, membrane-associated prostaglandin E(2) synthase-2, microsomal PG synthase-1, microsomal PGE synthase-1, microsomal PGE2 synthase, microsomal PGE2 synthase-1, microsomal prostaglandin E synthase, microsomal prostaglandin E synthase 1, microsomal prostaglandin E synthase type 1, microsomal prostaglandin E synthase type 2, microsomal prostaglandin E synthase type-2, microsomal prostaglandin E synthase-1, microsomal prostaglandin E synthase-2, microsomal prostaglandin E(2) synthase-1, microsomal prostaglandin E(2) synthase-2, microsomal prostaglandin E2 synthase 1, microsomal prostaglandin E2 synthase type 1, microsomal prostaglandin E2 synthase-1, microsomal prostaglandin synthase-1, microsomal prostaglandin-E synthase-1, mPGE synthase-2, mPGES, mPGES-1, mPGES-2, MPGES1, MPGES2, p23, PGE, PGE isomerase, PGE synthase, PGE synthase-1, PGE2, PGE2 isomerase, PGE2 synthase, PGE2-synthase, PGES, PGES-1, PGES-2, PGH-PGE isomerase, PGH2/PGE2 isomerase, prostagandin-E synthetase, Prostaglandin E synthase, prostaglandin E synthase 1, prostaglandin E synthase type 2, prostaglandin E synthase-1, prostaglandin E synthase-2, Prostaglandin E2 isomerase, prostaglandin E2 synthase, prostaglandin E2 synthase-1, prostaglandin E2 synthase-I, Prostaglandin endoperoxide E isomerase, Prostaglandin endoperoxide E2 isomerase, Prostaglandin endoperoxide-E isomerase, Prostaglandin H-E isomerase, Prostaglandin H-prostaglandin E isomerase, Prostaglandin R-prostaglandin E isomerase, prostaglandin synthase-1, prostaglandin-E synthase, Prostaglandin-H2 E-isomerase, PTGES

ECTree

     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.99 Other intramolecular oxidoreductases
                5.3.99.3 prostaglandin-E synthase

Source Tissue

Source Tissue on EC 5.3.99.3 - prostaglandin-E synthase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
low expression of mPEGS-2 in the urothelium
Manually annotated by BRENDA team
-
in normal breast the enzyme is seen in myoepithelial cells and in stromal fibroblasts and vascular smooth muscle, in breast disease, the enzyme is observed in epithelial cells adjacent to cancer, in scattered foci of fibrocystic disease, in ductal carcinoma in situ and in invasive cancers, in addition to myoepithelial cells
Manually annotated by BRENDA team
-
colocalized with cyclooxygenase-2
Manually annotated by BRENDA team
-
osteoarthritic chondrocyte
Manually annotated by BRENDA team
-
extravillous cytotrophoblast is strongly posistive for enzyme protein in the basal plate
Manually annotated by BRENDA team
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follicular dendritic cell
Manually annotated by BRENDA team
-
middle frontal gyrus tissue
Manually annotated by BRENDA team
intermediate abundance of the protein
Manually annotated by BRENDA team
expression of the primary form of PGES, mPGES-1
Manually annotated by BRENDA team
-
lowest protein expression
Manually annotated by BRENDA team
-
mesenchymal cells of the basal layer, co-localization of isoform mPGES-1 and COX-2 after induction of oesophagitis
Manually annotated by BRENDA team
-
peripheral blood monocyte, no basal expression of enzyme, but strong induction of expression by proinflammatory stimulation via LPS. In alternatively activated M2 monocytes-macrophages, interleukins IL-4, IL-13, and to a lesser extent, IL-10 or interferon IFN-gamma inhibit LPS-induced expression of enzyme. Induction of enzyme expression correlates with changes at the protein level and production of prostaglandin E2
Manually annotated by BRENDA team
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mPEGS-2
Manually annotated by BRENDA team
-
only isoform mPGES-1 can be found in neutrophils, it co-localizes with COX-2 and its expression is mainly constitutive
Manually annotated by BRENDA team
-
capillary-associated
Manually annotated by BRENDA team
at 24 h after fertilization, endothelial cells of the pharyngeal arch vasculature
Manually annotated by BRENDA team
-
pulmonary epithelial cell
Manually annotated by BRENDA team
-
high expression of mPEGS-2
Manually annotated by BRENDA team
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mPEGS-2
Manually annotated by BRENDA team
-
lowest protein expression
Manually annotated by BRENDA team
-
normal and psoriatic
Manually annotated by BRENDA team
-
mPEGS-2
Manually annotated by BRENDA team
-
enzyme protein is prominent in vesicles separating from syncytiotrophoblast into the intervillous space
Manually annotated by BRENDA team
-
placental trophoblast
Manually annotated by BRENDA team
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constitutive expression of enzyme is associated with increased prostaglandin E2 production and stimulation of growth. Inhibition of enzyme activity and expression block the release of prostaglandin E2 and decrease cellular proliferation. Antiproliferative effects may be overcome by exogenous prostaglandin E2
Manually annotated by BRENDA team
-
low expression of mPEGS-2
Manually annotated by BRENDA team
-
expression of cPEGS, mPEGS-2, and mPEGS-1
Manually annotated by BRENDA team
-
enzyme protein is elevated in the endometrium during spontaneous term labour and after estradiol treatment. Enzyme is localized to endometrial stromal cells
Manually annotated by BRENDA team
additional information