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667959, 678094, 690622, 693577, 693823, 706521, 714421, 714468, 715856, 715865, 748441, 748846 brenda
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low expression of mPEGS-2 in the urothelium
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in normal breast the enzyme is seen in myoepithelial cells and in stromal fibroblasts and vascular smooth muscle, in breast disease, the enzyme is observed in epithelial cells adjacent to cancer, in scattered foci of fibrocystic disease, in ductal carcinoma in situ and in invasive cancers, in addition to myoepithelial cells
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colocalized with cyclooxygenase-2
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osteoarthritic chondrocyte
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extravillous cytotrophoblast is strongly posistive for enzyme protein in the basal plate
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follicular dendritic cell
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middle frontal gyrus tissue
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intermediate abundance of the protein
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expression of the primary form of PGES, mPGES-1
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lowest protein expression
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mesenchymal cells of the basal layer, co-localization of isoform mPGES-1 and COX-2 after induction of oesophagitis
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peripheral blood monocyte, no basal expression of enzyme, but strong induction of expression by proinflammatory stimulation via LPS. In alternatively activated M2 monocytes-macrophages, interleukins IL-4, IL-13, and to a lesser extent, IL-10 or interferon IFN-gamma inhibit LPS-induced expression of enzyme. Induction of enzyme expression correlates with changes at the protein level and production of prostaglandin E2
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mPEGS-2
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only isoform mPGES-1 can be found in neutrophils, it co-localizes with COX-2 and its expression is mainly constitutive
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capillary-associated
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at 24 h after fertilization, endothelial cells of the pharyngeal arch vasculature
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pulmonary epithelial cell
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high expression of mPEGS-2
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mPEGS-2
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lowest protein expression
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normal and psoriatic
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mPEGS-2
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enzyme protein is prominent in vesicles separating from syncytiotrophoblast into the intervillous space
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mPGES-1
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placental trophoblast
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constitutive expression of enzyme is associated with increased prostaglandin E2 production and stimulation of growth. Inhibition of enzyme activity and expression block the release of prostaglandin E2 and decrease cellular proliferation. Antiproliferative effects may be overcome by exogenous prostaglandin E2
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low expression of mPEGS-2
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expression of cPEGS, mPEGS-2, and mPEGS-1
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enzyme protein is elevated in the endometrium during spontaneous term labour and after estradiol treatment. Enzyme is localized to endometrial stromal cells
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in brain mPGES-2 is detected in neurons, activated microglia, and endothelium, but not in resting microglia, astrocytes, or smooth muscle cells
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mPEGS-2
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weak enzyme expression
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weak enzyme expression
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weak enzyme expression, in the tubular epithelial cells of the caput and cauda
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weak enzyme expression
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from women undergoing treatment for infertility, expression of mPGES-2, mPGES-1, and cPGES
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mPEGS-2
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highest abundance of the protein
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in the tubular epithelial cells of the caput and cauda
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mPEGS-2
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pulmonary epithelial cell
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at least 2 different proteins with PGE-PGH isomerase activity
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epithelium cells
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epithelial cells of the basal layer, co-localization of isoform mPGES-1 and COX-2 after induction of oesophagitis
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pEJ-ras transformed
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gingival fibroblast
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3Y1 cell
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colocalized with cyclooxygenase-2
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low level of cPGES
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low level of mPGES-2
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mPGES-1
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both microsomal enzyme immunostaining and mRNA, enzyme is induced by equine and human chorionic gonadotropin treatment
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faint expression levels
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mPEGS-2
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mPEGS-2
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highest activity of nongenital organs
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mainly inner medulla, expression overview
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intermediate abundance of the protein
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intermediate abundance of the protein
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mPGES-2 colocalizedswith microglia in activated (amoeboid-shaped) cells
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faint expression levels
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expressed to a lesser extent
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isoform mPGES-1 localizes mostly in myometrial and vascular smooth muscle cells of pregnant women. Isoform cPGES is diffusely located throughout the myometrium. Expression of COX-2 and isoform mPGES-1 mRNA with term labour, whereas cPGES expression does not change. Interleukin 1beta stimulates release of prostaglandin E2 by myometrical smooth muscle cells and increases COX-2 and mPGES-1 mRNA and protein expression
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isoform mPGES-2 protein is largely in stromal cells surrounding smooth vascular muscle. Expression of mPGES-2 mRNA increases with term labour and preterm labour
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myometrial smooth muscle cell
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intermediate abundance of the protein
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mPEGS-2
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exclusive localization of cytosolic enzyme, no obvious effect of treatment with equine chorionic gonadotropin on mRNA or protein level
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mPEGS-2
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prostaglandin E synthases are mostly concentrated in the oviductal epithelial layer and primarily expressed in the ampulla section of the oviduct and to a lesser extent in the isthmus and the isthmic-ampullary junction
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prostaglandin E synthases are mostly concentrated in the oviductal epithelial layer and primarily expressed in the ampulla section of the oviduct and to a lesser extent in the isthmus and the isthmic-ampullary junction, the mPGES-1 protein is highly expressed in the contralateral oviduct
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prostaglandin E synthases are mostly concentrated in the oviductal epithelial layer and primarily expressed in the ampulla section of the oviduct and to a lesser extent in the isthmus and the isthmic-ampullary junction, the mPGES-2 is mostly expressed in the ipsilateral oviduct
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epithelium, mPEGS-2
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immunolocalized in extravillous trophoblasts and macrophages, in early gestation also in cytotrophoblasts and syncytiotrophoblasts
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immunolocalized to the fibroblasts and macrophages in villous stroma, also in apoptotic early gestational syncytiotrophoblasts
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application of glucocorticoids to mother or fetus significantly stimulate enzyme isoform mPGES1 in placenta. Enzyme is localized to placental trophoblast cells
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barely detectable
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mPEGS-2
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moderate enzyme expression
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almost undetectable
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mPEGS-2
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expressed to a lesser extent
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faint expression levels
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expressed to a lesser extent
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spermatogonia, Sertoli cells and primary spermatocytes
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mPEGS-2
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weak enzyme expression, Leydig cells, Sertoli cells, seminiferous tubules
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epithelial cells, low expression of mPEGS-2
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intrauterine tissue of pregnant ewe
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ampulla
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in the epithelium from the proximal segment to the distal portion of the vas deferens and ampulla
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and other genital accessory organs
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strong enzyme expression, in the epithelium from the proximal segment to the distal portion of the vas deferens and ampulla
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weak enzyme expression
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cells express both microsomal isoforms mPGES-1 and mPGES-2 and cytosolic isoform cPGES
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cells express both microsomal isoforms mPGES-1 and mPGES-2 and cytosolic isoform cPGES. Isoform mPGES-1 contributes most to total activity and is induced by interleukin IL-1beta, which in turn reduces the ability of cells to produce prostaglandin I2
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additional information
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endometrium, located in epithelial, glandular and stromal cells
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additional information
endometrium, located in epithelial, glandular and stromal cells
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additional information
endometrium, located in epithelial, glandular and stromal cells
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additional information
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DU4475 cell, highest protein expression
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additional information
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Hs 578T cell
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additional information
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in patients with rheumatoid arthritis, the protein is overexpressed in synovial tissue, particularly by macrophages and fibroblasts in the synovial lining layer
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additional information
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ZR-75-1 cell
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additional information
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tissue-specific expression analysis
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additional information
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MPGES-1 is not detected in LNCaP cells
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additional information
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seminal vesicular gland
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additional information
tissue distribution of isozme expression, overview
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additional information
tissue distribution of isozme expression, overview
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additional information
tissue distribution of isozme expression, overview
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additional information
tissue distribution of isozyme expression, overview
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additional information
tissue distribution of isozyme expression, overview
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additional information
tissue distribution of isozyme expression, overview
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additional information
abundant tissue distribution of isozyme mPGES2
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additional information
protein expression occurs in luminal epithelial and stromal cells around the implanting blastocyst on day 5 of pregnancy, with the progression of implantation to day 6, the protein is mainly expressed in the cells of the primary decidual zone
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additional information
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distribution of mPEGS-2, overview
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additional information
no microsomal enzyme immunostaining or mRNA in thecal cell or oocyte
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additional information
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no microsomal enzyme immunostaining or mRNA in thecal cell or oocyte
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additional information
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the enzyme expression is altered in rats with nephrogenic and central diabetes insipidus, expression overview
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additional information
endometrium, mainly in luminal and glandular epithelium, higher levels of PGES-1 mRNA occur during pregnancy on days 10-11 when compared with days 12-17, intermediate levels of PGES-1 protein are observed on days 10-13, afterwards, PGES-1 mRNA and protein expression decrease, followed by an increase from days 18-19 or 22-23 of pregnancy, highest mRNA and protein levels are reached on days 24-25
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additional information
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endometrium, mainly in luminal and glandular epithelium, higher levels of PGES-1 mRNA occur during pregnancy on days 10-11 when compared with days 12-17, intermediate levels of PGES-1 protein are observed on days 10-13, afterwards, PGES-1 mRNA and protein expression decrease, followed by an increase from days 18-19 or 22-23 of pregnancy, highest mRNA and protein levels are reached on days 24-25
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