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Literature summary for 5.3.99.3 extracted from

  • Ikeda-Matsuo, Y.; Hirayama, Y.; Ota, A.; Uematsu, S.; Akira, S.; Sasaki, Y.
    Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity (2010), Br. J. Pharmacol., 159, 1174-1186.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.99.3

Inhibitors

Inhibitors Comment Organism Structure
MK-886 glutamate-induced PGE2 production is suppressed almost completely by MK-886 at a concentration of 0.003 mM or higher Mus musculus
MK-886 glutamate-induced PGE2 production is suppressed almost completely by MK-886 at a concentration of 0.003 mM or higher Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Mus musculus
-
hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Mus musculus Prostaglandin E2
-
 ?
Prostaglandin H2
-
 Rattus norvegicus Prostaglandin E2
-
 ?

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase-1
-
 Mus musculus
microsomal prostaglandin E synthase-1
-
 Rattus norvegicus
mPGES-1
-
 Mus musculus
mPGES-1
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0024
-
-
 Mus musculus MK-886
0.0024
-
-
 Rattus norvegicus MK-886

Expression

Organism Comment Expression
Mus musculus 1 mM glutamate up-regulates the expression of mPGES-1 to about 3fold that in the controls up
Rattus norvegicus 1 mM glutamate up-regulates the expression of mPGES-1 to about 3fold that in the controls up

General Information

General Information Comment Organism
physiological function microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are co-induced by excess glutamate in ischaemic brain. mPGES-1 activity is required for cyclooxygenase-2 to cause neuronal damage in ischaemic injury Mus musculus
physiological function microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are co-induced by excess glutamate in ischaemic brain. mPGES-1 activity is required for cyclooxygenase-2 to cause neuronal damage in ischaemic injury Rattus norvegicus