Reference on EC 5.3.99.3 - prostaglandin-E synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tanaka, Y.; Ward, S.L.; Smith, W.L.
Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes
J. Biol. Chem.
262
1374-1381
1987
Ovis aries
McNamara, D.B.; Hussey, J.L.; Kerstein, M.D.; Rosenson, R.S.; Hyman, A.L.; Kadowitz, P.J.
Modulation of prostacyclin synthetase and unmasking of PGE2 isomerase in bovine coronary arterial microsomes
Biochem. Biophys. Res. Commun.
118
33-39
1984
Bos taurus, Canis lupus familiaris, Ovis aries, Homo sapiens
Moonen, P.; Buytenhek, M.; Nugteren, D.H.
Purification of PGH-PGE isomerase from sheep vesicular glands
Methods Enzymol.
86
84-91
1982
Ovis aries
Ogino, N.; Miyamoto, T.; Yamamoto, S.; Hayaishi, O.
Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme
J. Biol. Chem.
252
890-895
1977
Bos taurus
Kelner, M.J.; Uglik, S.F.
Mechanism of prostaglandin E2 release and increase in PGH2/PGE2 isomerase activity by PDGF: involvement of nitric oxide
Arch. Biochem. Biophys.
321
240-243
1994
Homo sapiens
Shalinsky, D.R.; McNamara, D.B.; Agrawal, K.C.
Inhibition of GSH-dependent PGH2 isomerase in mammary adenocarcinoma cells by allicin
Prostaglandins
37
135-148
1989
Mus musculus
Kelner, M.J.; Uglik, S.F.
PDGF-induces the glutathione-dependent enzyme PGH2/PGE2 isomerase in NIH3T3 and pEJ transformed fibroblasts
Biochem. Biophys. Res. Commun.
198
298-303
1994
Homo sapiens
Matsumoto, H.; Naraba, H.; Murakami, M.; Kudo, I.; Yamaki, K.; Ueno, A.; Oh-ishi, S.
Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages
Biochem. Biophys. Res. Commun.
230
110-114
1997
Rattus norvegicus
Watanabe, K.; Kurihara, K.; Tokunaga, Y.; Hayaishi, O.
Two types of microsomal prostaglandin E synthase: glutathione-dependent and -independent prostaglandin E synthases
Biochem. Biophys. Res. Commun.
235
148-152
1997
Rattus norvegicus
Meyer, D.J.; Muimo, R.; Thomas, M.; Coates, D.; Isaac, R.E.
Purification and characterization of prostaglandin-H E-isomerase, a sigma-class glutathione S-transferase, from Ascaridia galli
Biochem. J.
313
223-227
1996
Ascaridia galli, Rattus norvegicus
Han, R.; Tsui, S.; Smith, T.J.
Up-regulation of prostaglandin E2 synthesis by interleukin-1b in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression
J. Biol. Chem.
277
16355-16364
2002
Homo sapiens
Thoren, S.; Weinander, R.; Saha, S.; Jegerschoeld, C.; Pettersson, P.L.; Samuelsson, B.; Hebert, H.; Hamberg, M.; Morgenstern, R.; Jakobsson, P.J.
Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination
J. Biol. Chem.
278
22199-22209
2003
Homo sapiens
Jakobsson, P.J.; Thoren, S.; Morgenstern, R.; Samuelsson, B.
Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
Proc. Natl. Acad. Sci. USA
96
7220-7225
1999
Homo sapiens (O14684), Homo sapiens
Ouellet, M.; Falgueyret, J.P.; Ear, P.H.; Pen, A.; Mancini, J.A.; Riendeau, D.; David Percival, M.
Purification and characterization of recombinant microsomal prostaglandin E synthase-1
Protein Expr. Purif.
26
489-495
2002
Homo sapiens (O14684), Homo sapiens
Vazquez-Tello, A.; Fan, L.; Hou, X.; Joyal, J.S.; Mancini, J.A.; Quiniou, C.; Clyman, R.I.; Gobeil, F.Jr.; Varma, D.R.; Chemtob, S.
Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain
Am. J. Physiol.
287
R1155-R1163
2004
Homo sapiens, Rattus norvegicus, Sus scrofa
Giannico, G.; Mendez, M.; LaPointe, M.C.
Regulation of the membrane-localized prostaglandin E synthases mPGES-1 and mPGES-2 in cardiac myocytes and fibroblasts
Am. J. Physiol.
288
H165-H174
2005
Rattus norvegicus
Pini, B.; Grosser, T.; Lawson, J.A.; Price, T.S.; Pack, M.A.; FitzGerald, G.A.
Prostaglandin E Synthases in Zebrafish
Arterioscler. Thromb. Vasc. Biol.
25
315-320
2005
Danio rerio (Q5IHX6), Danio rerio (Q5IHX7), Danio rerio
Kobayashi, T.; Nakatani, Y.; Tanioka, T.; Tsujimoto, M.; Nakajo, S.; Nakaya, K.; Murakami, M.; Kudo, I.
Regulation of cytosolic prostaglandin E synthase by phosphorylation
Biochem. J.
381
59-69
2004
Rattus norvegicus
Parent, J.; Fortier, M.A.
Expression and contribution of three different isoforms of prostaglandin E synthase in the bovine endometrium
Biol. Reprod.
73
36-44
2005
Bos taurus, Bos taurus (Q3ZBF7), Bos taurus (Q66LN0)
Waclawik, A.; Rivero-Muller, A.; Blitek, A.; Kaczmarek, M.M.; Brokken, L.J.; Watanabe, K.; Rahman, N.A.; Ziecik, A.J.
Molecular cloning and spatiotemporal expression of prostaglandin F synthase and microsomal prostaglandin E synthase-1 in porcine endometrium
Endocrinology
147
210-221
2006
Sus scrofa (Q2TJZ7), Sus scrofa
Kudo, I.; Murakami, M.
Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis
J. Biochem. Mol. Biol.
38
633-638
2005
Homo sapiens, Mus musculus, Rattus norvegicus
Wang, X.; Su, Y.; Deb, K.; Raposo, M.; Morrow, J.D.; Reese, J.; Paria, B.C.
Prostaglandin E2 is a product of induced prostaglandin-endoperoxide synthase 2 and microsomal-type prostaglandin E synthase at the implantation site of the hamster
J. Biol. Chem.
279
30579-30587
2004
Mesocricetus auratus (Q6BCL2)
Yamada, T.; Komoto, J.; Watanabe, K.; Ohmiya, Y.; Takusagawa, F.
Crystal structure and possible catalytic mechanism of microsomal prostaglandin E synthase type 2 (mPGES-2)
J. Mol. Biol.
348
1163-1176
2005
Macaca fascicularis (Q9N0A4)
Mehrotra, S.; Morimiya, A.; Agarwal, B.; Konger, R.; Badve, S.
Microsomal prostaglandin E(2) synthase-1 in breast cancer: a potential target for therapy
J. Pathol.
208
356-363
2006
Homo sapiens
Pettersson, P.L.; Thoren, S.; Jakobsson, P.J.
Human microsomal prostaglandin E synthase 1: a member of the MAPEG protein superfamily
Methods Enzymol.
401
147-161
2005
Homo sapiens
Meadows, J.W.; Pitzer, B.; Brockman, D.E.; Myatt, L.
Differential localization of prostaglandin E synthase isoforms in human placental cell types
Placenta
25
259-265
2004
Homo sapiens
Lazarus, M.; Eguchi, N.; Matsumoto, S.; Nagata, N.; Yano, T.; Killian, G.J.; Urade, Y.
Species-specific expression of microsomal prostaglandin E synthase-1 and cyclooxygenases in male monkey reproductive organs
Prostaglandins Leukot. Essent. Fatty Acids
71
233-240
2004
Oryctolagus cuniculus, Macaca fascicularis, Rattus norvegicus, Sus scrofa
Kotnik, P.; Nielsen, J.; Kwon, T.H.; Krzisnik, C.; Fr?kiaer, J.; Nielsen, S.
Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus
Am. J. Physiol. Renal Physiol.
288
F1053-F1068
2005
Rattus norvegicus
Yang, G.; Chen, L.; Zhang, Y.; Zhang, X.; Wu, J.; Li, S.; Wei, M.; Zhang, Z.; Breyer, M.D.; Guan, Y.
Expression of mouse membrane-associated prostaglandin E(2) synthase-2 (mPGES-2) along the urogenital tract
Biochim. Biophys. Acta
1761
1459-1468
2006
Mus musculus
Riendeau, D.; Aspiotis, R.; Ethier, D.; Gareau, Y.; Grimm, E.L.; Guay, J.; Guiral, S.; Juteau, H.; Mancini, J.A.; Methot, N.; Rubin, J.; Friesen, R.W.
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886
Bioorg. Med. Chem. Lett.
15
3352-3355
2005
Homo sapiens
Duffy, D.M.; Seachord, C.L.; Dozier, B.L.
Microsomal prostaglandin E synthase-1 (mPGES-1) is the primary form of PGES expressed by the primate periovulatory follicle
Hum. Reprod.
20
1485-1492
2005
Homo sapiens, Macaca fascicularis (Q5DI74), Macaca fascicularis (Q6PWL5), Macaca fascicularis (Q9N0A4)
Stark, K.; Toermae, H.; Oliw, E.H.
Co-localization of COX-2, CYP4F8, and mPGES-1 in epidermis with prominent expression of CYP4F8 mRNA in psoriatic lesions
Prostaglandins Other Lipid Mediat.
79
114-125
2006
Homo sapiens
Fujikura, T.; Mukai, M.
Prostaglandin E2 synthase in syncytiotrophoblastic vesicles found in the placental intervillous space
Am. J. Obstet. Gynecol.
196
361-361
2007
Homo sapiens
-
Moon, Y.; Lee, M.; Yang, H.
Involvement of early growth response gene 1 in the modulation of microsomal prostaglandin E synthase 1 by epigallocatechin gallate in A549 human pulmonary epithelial cells
Biochem. Pharmacol.
73
125-135
2007
Homo sapiens
Yamada, T.; Takusagawa, F.
PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme
Biochemistry
46
8414-8424
2007
Homo sapiens
St-Onge, M.; Flamand, N.; Biarc, J.; Picard, S.; Bouchard, L.; Dussault, A.; Laflamme, C.; James, M.J.; Caughey, G.E.; Cleland, L.G.; Borgeat, P.; Pouliot, M.
Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils
Biochim. Biophys. Acta
1771
1235-1245
2007
Homo sapiens
Bage, T.; Modeer, T.; Kawakami, T.; Quezada, H.C.; Yucel-Lindberg, T.
Regulation of prostaglandin E synthases: effects of siRNA-mediated inhibition of microsomal prostaglandin E synthase-1
Biochim. Biophys. Acta
1773
1589-1598
2007
Homo sapiens
Huang, X.; Yan, W.; Gao, D.; Tong, M.; Tai, H.H.; Zhan, C.G.
Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis
Bioorg. Med. Chem.
14
3553-3562
2006
Homo sapiens
Zhang, Q.; Collins, V.; Chakrabarty, K.; Wolf, R.F.; Unno, N.; Howe, D.; Rose, J.C.; Wu, W.X.
Regulation of membrane-associated prostaglandin E2 synthase 1 in pregnant sheep intrauterine tissues by glucocorticoid and estradiol
Endocrinology
147
3719-3726
2006
Ovis aries
Hayakawa, T.; Fujiwara, Y.; Hamaguchi, M.; Sugawa, T.; Okuyama, M.; Sasaki, E.; Watanabe, T.; Tominaga, K.; Oshitani, N.; Higuchi, K.; Arakawa, T.
Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis
Gut
55
450-456
2006
Rattus norvegicus
Francois, H.; Facemire, C.; Kumar, A.; Audoly, L.; Koller, B.; Coffman, T.
Role of microsomal prostaglandin E synthase 1 in the kidney
J. Am. Soc. Nephrol.
18
1466-1475
2007
Mus musculus
Abdulhameed, M.D.; Hamza, A.; Liu, J.; Huang, X.; Zhan, C.G.
Human microsomal prostaglandin E synthase-1 (mPGES-1) Binding with inhibitors and the quantitative structure-activity Correlation
J. Chem. Inf. Model.
48
179-85
2008
Homo sapiens
Sun, T.; Deng, W.B.; Diao, H.L.; Ni, H.; Bai, Y.Y.; Ma, X.H.; Xu, L.B.; Yang, Z.M.
Differential expression and regulation of prostaglandin E synthases in the mouse ovary during sexual maturation and luteal development
J. Endocrinol.
189
89-101
2006
Mus musculus (Q9JM51), Mus musculus
Inada, M.; Matsumoto, C.; Uematsu, S.; Akira, S.; Miyaura, C.
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation
J. Immunol.
177
1879-1885
2006
Mus musculus
Mosca, M.; Polentarutti, N.; Mangano, G.; Apicella, C.; Doni, A.; Mancini, F.; De Bortoli, M.; Coletta, I.; Polenzani, L.; Santoni, G.; Sironi, M.; Vecchi, A.; Mantovani, A.
Regulation of the microsomal prostaglandin E synthase-1 in polarized mononuclear phagocytes and its constitutive expression in neutrophils
J. Leukocyte Biol.
82
320-326
2007
Homo sapiens
Camacho, M.; Gerboles, E.; Escudero, J.R.; Anton, R.; Garcia-Moll, X.; Vila, L.
Microsomal prostaglandin E synthase-1, which is not coupled to a particular cyclooxygenase isoenzyme, is essential for prostaglandin E(2) biosynthesis in vascular smooth muscle cells
J. Thromb. Haemost.
5
1411-1419
2007
Homo sapiens, Homo sapiens (Q9H7Z7)
Payner, T.; Leaver, H.A.; Knapp, B.; Whittle, I.R.; Trifan, O.C.; Miller, S.; Rizzo, M.T.
Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A
Mol. Cancer Ther.
5
1817-1826
2006
Homo sapiens
Astle, S.; Newton, R.; Thornton, S.; Vatish, M.; Slater, D.M.
Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour
Mol. Hum. Reprod.
13
69-75
2007
Homo sapiens, Homo sapiens (Q9H7Z7)
Ikeda-Matsuo, Y.; Ota, A.; Fukada, T.; Uematsu, S.; Akira, S.; Sasaki, Y.
Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury
Proc. Natl. Acad. Sci. USA
103
11790-11795
2006
Mus musculus
Chaudhry, U.A.; Zhuang, H.; Crain, B.J.; Dore, S.
Elevated microsomal prostaglandin-E synthase-1 in Alzheimers disease
Alzheimers Dement. (N. Y.)
4
6-13
2008
Homo sapiens
Inoue, W.; Somay, G.; Poole, S.; Luheshi, G.N.
Immune-to-brain signaling and central prostaglandin E2 synthesis in fasted rats with altered lipopolysaccharide-induced fever
Am. J. Physiol. Regul. Integr. Comp. Physiol.
295
R133-R143
2008
Rattus norvegicus
Hetu, P.O.; Ouellet, M.; Falgueyret, J.P.; Ramachandran, C.; Robichaud, J.; Zamboni, R.; Riendeau, D.
Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E2 synthase-1
Arch. Biochem. Biophys.
477
155-162
2008
Homo sapiens
Watanabe, K.; Ito, S.; Yamamoto, S.
Studies on membrane-associated prostaglandin E synthase-2 with reference to production of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT)
Biochem. Biophys. Res. Commun.
367
782-786
2008
Bos taurus
Aquino, M.; Guerrero, M.D.; Bruno, I.; Terencio, M.C.; Paya, M.; Riccio, R.
Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the gamma-hydroxybutenolide scaffold
Bioorg. Med. Chem.
16
9056-9064
2008
Mus musculus (Q9JM51)
Kim, W.I.; Choi, K.A.; Do, H.S.; Yu, Y.G.
Expression and purification of human mPGES-1 in E. coli and identification of inhibitory compounds from a drug-library
BMB Rep.
41
808-813
2008
Homo sapiens
Takasu, S.; Tsukamoto, T.; Cao, X.Y.; Toyoda, T.; Hirata, A.; Ban, H.; Yamamoto, M.; Sakai, H.; Yanai, T.; Masegi, T.; Oshima, M.; Tatematsu, M.
Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice
Cancer Sci.
99
2356-2364
2008
Mus musculus
Bogan, R.L.; Murphy, M.J.; Stouffer, R.L.; Hennebold, J.D.
Prostaglandin synthesis, metabolism, and signaling potential in the rhesus macaque corpus luteum throughout the luteal phase of the menstrual cycle
Endocrinology
149
5861-5871
2008
Macaca mulatta
Frasor, J.; Weaver, A.E.; Pradhan, M.; Mehta, K.
Synergistic up-regulation of prostaglandin E synthase expression in breast cancer cells by 17beta-estradiol and proinflammatory cytokines
Endocrinology
149
6272-6279
2008
Homo sapiens
Jia, Z.; Guo, X.; Zhang, H.; Wang, M.H.; Dong, Z.; Yang, T.
Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress
Hypertension
52
952-959
2008
Mus musculus
Hammarberg, T.; Hamberg, M.; Wetterholm, A.; Hansson, H.; Samuelsson, B.; Haeggstroem, J.Z.
Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2{alpha}
J. Biol. Chem.
284
301-305
2009
Homo sapiens (O14684), Homo sapiens
Xing, L.; Kurumbail, R.G.; Frazier, R.B.; Davies, M.S.; Fujiwara, H.; Weinberg, R.A.; Gierse, J.K.; Caspers, N.; Carter, J.S.; McDonald, J.J.; Moore, W.M.; Vazquez, M.L.
Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions
J. Comput. Aided Mol. Des.
23
13-24
2009
Homo sapiens (O14684), Homo sapiens
Lee, I.Y.; Cho, W.; Kim, J.; Park, C.S.; Choe, J.
Human follicular dendritic cells interact with T cells via expression and regulation of cyclooxygenases and prostaglandin E and I synthases
J. Immunol.
180
1390-1397
2008
Homo sapiens
Wang, M.; Song, W.L.; Cheng, Y.; Fitzgerald, G.A.
Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease
J. Intern. Med.
263
500-505
2008
Mus musculus
Friesen, R.W.; Mancini, J.A.
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target
J. Med. Chem.
51
4059-4067
2008
Homo sapiens
Koeberle, A.; Zettl, H.; Greiner, C.; Wurglics, M.; Schubert-Zsilavecz, M.; Werz, O.
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase
J. Med. Chem.
51
8068-8076
2008
Homo sapiens
Kim, B.; Lee, J.H.; Yang, M.S.; Jou, I.; Joe, E.H.
Retinoic acid enhances prostaglandin E2 production through increased expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in rat brain microglia
J. Neurosci. Res.
86
1353-1360
2008
Rattus norvegicus
Koeberle, A.; Siemoneit, U.; Buehring, U.; Northoff, H.; Laufer, S.; Albrecht, W.; Werz, O.
Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1
J. Pharmacol. Exp. Ther.
326
975-982
2008
Homo sapiens
Hamza, A.; Abdulhameed, M.D.; Zhan, C.G.
Understanding microscopic binding of human microsomal prostaglandin E synthase-1 with substrates and inhibitors by molecular modeling and dynamics simulation
J. Phys. Chem. B
112
7320-7329
2008
Homo sapiens (O14684), Homo sapiens
Jegerschoeld, C.; Pawelzik, S.C.; Purhonen, P.; Bhakat, P.; Gheorghe, K.R.; Gyobu, N.; Mitsuoka, K.; Morgenstern, R.; Jakobsson, P.J.; Hebert, H.
Structural basis for induced formation of the inflammatory mediator prostaglandin E2
Proc. Natl. Acad. Sci. USA
105
11110-11115
2008
Homo sapiens (O14684), Homo sapiens
Sandee, D.; Sivanuntakorn, S.; Vichai, V.; Kramyu, J.; Kirtikara, K.
Up-regulation of microsomal prostaglandin E synthase-1 in COX-1 and COX-2 knock-out mouse fibroblast cell lines
Prostaglandins Other Lipid Mediat.
88
111-116
2009
Mus musculus
Jania, L.A.; Chandrasekharan, S.; Backlund, M.G.; Foley, N.A.; Snouwaert, J.; Wang, I.M.; Clark, P.; Audoly, L.P.; Koller, B.H.
Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E(2) biosynthesis
Prostaglandins Other Lipid Mediat.
88
73-81
2009
Mus musculus
Kamei, D.; Murakami, M.; Sasaki, Y.; Nakatani, Y.; Majima, M.; Ishikawa, Y.; Ishii, T.; Uematsu, S.; Akira, S.; Hara, S.; Kudo, I.
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
Biochem. J.
425
361-371
2010
Mus musculus
Megias, J.; Guillen, M.I.; Clerigues, V.; Rojo, A.I.; Cuadrado, A.; Castejon, M.A.; Gomar, F.; Alcaraz, M.J.
Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes
Biochem. Pharmacol.
77
1806-1813
2009
Homo sapiens
Mbalaviele, G.; Pauley, A.M.; Shaffer, A.F.; Zweifel, B.S.; Mathialagan, S.; Mnich, S.J.; Nemirovskiy, O.V.; Carter, J.; Gierse, J.K.; Wang, J.L.; Vazquez, M.L.; Moore, W.M.; Masferrer, J.L.
Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor
Biochem. Pharmacol.
79
1445-1454
2010
Homo sapiens, Rattus norvegicus
Li, Y.; Angelastro, M.; Shimshock, S.; Reiling, S.; Vaz, R.J.
On the mechanism of microsomal prostaglandin E synthase type-2--a theoretical study of endoperoxide reaction with MeS-
Bioorg. Med. Chem. Lett.
20
338-340
2010
Homo sapiens
Ikeda-Matsuo, Y.; Hirayama, Y.; Ota, A.; Uematsu, S.; Akira, S.; Sasaki, Y.
Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity
Br. J. Pharmacol.
159
1174-1186
2010
Mus musculus, Rattus norvegicus
Chaudhry, U.; Zhuang, H.; Dore, S.
Microsomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimers disease
Exp. Neurol.
223
359-365
2010
Homo sapiens
Facemire, C.S.; Griffiths, R.; Audoly, L.P.; Koller, B.H.; Coffman, T.M.
The impact of microsomal prostaglandin E synthase 1 on blood pressure is determined by genetic background
Hypertension
55
531-538
2010
Mus musculus
Takemiya, T.; Matsumura, K.; Sugiura, H.; Maehara, M.; Yasuda, S.; Uematsu, S.; Akira, S.; Yamagata, K.
Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate
J. Neurosci. Res.
88
381-390
2010
Mus musculus, Rattus norvegicus
Hamza, A.; Tong, M.; AbdulHameed, M.D.; Liu, J.; Goren, A.C.; Tai, H.H.; Zhan, C.G.
Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis
J. Phys. Chem. B
114
5605-5616
2010
Homo sapiens (O14684), Homo sapiens
Sveinbjoernsson, B.; Schumacher, M.C.; Hamberg, M.; Samuelsson, B.; Jakobsson, P.J.; Kogner, P.; Radmark, O.
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells
Proc. Natl. Acad. Sci. USA
106
18757-18762
2009
Homo sapiens
Wu, D.; Mennerich, D.; Arndt, K.; Sugiyama, K.; Ozaki, N.; Schwarz, K.; Wei, J.; Wu, H.; Bishopric, N.H.; Doods, H.
The effects of microsomal prostaglandin E synthase-1 deletion in acute cardiac ischemia in mice
Prostaglandins Leukot. Essent. Fatty Acids
81
31-33
2009
Mus musculus
Gauvreau, D.; Moisan, V.; Roy, M.; Fortier, M.A.; Bilodeau, J.F.
Expression of prostaglandin E synthases in the bovine oviduct
Theriogenology
73
103-111
2010
Bos taurus (Q3ZBF7), Bos taurus (Q66LN0), Bos taurus (Q95L14), Bos taurus
Ae, T.; Ohno, T.; Hattori, Y.; Suzuki, T.; Hosono, K.; Minamino, T.; Sato, T.; Uematsu, S.; Akira, S.; Koizumi, W.; Majima, M.
Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers
Am. J. Physiol. Gastrointest. Liver Physiol.
299
G1139-G1146
2010
Mus musculus
Numao, A.; Hosono, K.; Suzuki, T.; Hayashi, I.; Uematsu, S.; Akira, S.; Ogino, Y.; Kawauchi, H.; Unno, N.; Majima, M.
The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model
Biomed. Pharmacother.
65
77-84
2011
Mus musculus
Wu, T.Y.; Juteau, H.; Ducharme, Y.; Friesen, R.W.; Guiral, S.; Dufresne, L.; Poirier, H.; Salem, M.; Riendeau, D.; Mancini, J.; Brideau, C.
Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1
Bioorg. Med. Chem. Lett.
20
6978-6982
2010
Homo sapiens
Greiner, C.; Zettl, H.; Koeberle, A.; Pergola, C.; Northoff, H.; Schubert-Zsilavecz, M.; Werz, O.
Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1
Bioorg. Med. Chem.
19
3394-3401
2011
Homo sapiens
Barbieri, S.S.; Amadio, P.; Gianellini, S.; Zacchi, E.; Weksler, B.B.; Tremoli, E.
Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase
FASEB J.
25
3731-3740
2011
Mus musculus
Lu, D.; Han, C.; Wu, T.
Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression
Gastroenterology
140
2084-2094
2011
Homo sapiens
Pawelzik, S.C.; Uda, N.R.; Spahiu, L.; Jegerschoeld, C.; Stenberg, P.; Hebert, H.; Morgenstern, R.; Jakobsson, P.J.
Identification of key residues determining species differences in inhibitor binding of microsomal prostaglandin E synthase-1
J. Biol. Chem.
285
29254-29261
2010
Homo sapiens, Rattus norvegicus
De Simone, R.; Chini, M.G.; Bruno, I.; Riccio, R.; Mueller, D.; Werz, O.; Bifulco, G.
Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents
J. Med. Chem.
54
1565-1575
2011
Homo sapiens
Hieke, M.; Greiner, C.; Dittrich, M.; Reisen, F.; Schneider, G.; Schubert-Zsilavecz, M.; Werz, O.
Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid
J. Med. Chem.
54
4490-4507
2011
Homo sapiens
Isono, M.; Suzuki, T.; Hosono, K.; Hayashi, I.; Sakagami, H.; Uematsu, S.; Akira, S.; DeClerck, Y.A.; Okamoto, H.; Majima, M.
Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice
Life Sci.
88
693-700
2011
Mus musculus
Nakatani, Y.; Hokonohara, Y.; Tajima, Y.; Kudo, I.; Hara, S.
Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH
Prostaglandins Other Lipid Mediat.
94
112-117
2011
Mus musculus, Rattus norvegicus
Yamamoto, K.; Suzuki, M.; Higashiura, A.; Aritake, K.; Urade, Y.; Uodome, N.; Hossain, T.; Nakagawa, A.
New insights into the catalytic mechanism of Bombyx mori prostaglandin E synthase gained from structure-function analysis
Biochem. Biophys. Res. Commun.
440
762-767
2013
Bombyx mori
Shang, E.; Wu, Y.; Liu, P.; Liu, Y.; Zhu, W.; Deng, X.; He, C.; He, S.; Li, C.; Lai, L.
Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1
Bioorg. Med. Chem. Lett.
24
2764-2767
2014
Homo sapiens
Wiegard, A.; Hanekamp, W.; Griessbach, K.; Fabian, J.; Lehr, M.
Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1
Eur. J. Med. Chem.
48
153-163
2012
Homo sapiens
Takusagawa, F.
Microsomal prostaglandin E synthase type 2 (mPGES2) is a glutathione-dependent heme protein, and dithiothreitol dissociates the bound heme to produce active prostaglandin E2 synthase in vitro
J. Biol. Chem.
288
10166-10175
2013
Macaca fascicularis (Q9N0A4)
Sjoegren, T.; Nord, J.; Ek, M.; Johansson, P.; Liu, G.; Geschwindner, S.
Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily
Proc. Natl. Acad. Sci. USA
110
3806-3811
2013
Homo sapiens (O14684), Homo sapiens
Yao, L.; Chen, W.; Han, C.; Wu, T.
Microsomal prostaglandin E synthase-1 protects against Fas-induced liver injury
Am. J. Physiol. Gastrointest. Liver Physiol.
310
G1071-G1080
2016
Mus musculus
Korotkova, M.; Jakobsson, P.
Characterization of microsomal prostaglandin E synthase 1 inhibitors
Basic Clin. Pharmacol. Toxicol.
114
64-69
2014
Homo sapiens (O14684)
Nakatani, Y.; Miyazaki, Y.; Hara, S.
Cytosolic prostaglandin E synthase is involved in c-Fos expression in rat fibroblastic 3Y1 cells
Biol. Pharm. Bull.
40
1963-1967
2017
Mus musculus, Rattus norvegicus
Gram, A.; Fox, B.; Buechler, U.; Boos, A.; Hoffmann, B.; Kowalewski, M.P.
Canine placental prostaglandin E2 synthase expression, localization, and biological functions in providing substrates for prepartum PGF2alpha synthesis
Biol. Reprod.
91
154
2014
Canis lupus familiaris
Banerjee, A.; Pawar, M.Y.; Patil, S.; Yadav, P.S.; Kadam, P.A.; Kattige, V.G.; Deshpande, D.S.; Pednekar, P.V.; Pisat, M.K.; Gharat, L.A.
Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E2 synthase-1 inhibitors
Bioorg. Med. Chem. Lett.
24
4838-4844
2014
Homo sapiens (O14684), Homo sapiens
Kuklish, S.L.; Antonysamy, S.; Bhattachar, S.N.; Chandrasekhar, S.; Fisher, M.J.; Fretland, A.J.; Gooding, K.; Harvey, A.; Hughes, N.E.; Luz, J.G.; Manninen, P.R.; McGee, J.E.; Navarro, A.; Norman, B.H.; Partridge, K.M.; Quimby, S.J.; Schiffler, M.A.; Sloan, A.V.; Warshawsky, A.M.; York, J.S.; Yu, X.P.
Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors
Bioorg. Med. Chem. Lett.
26
4824-4828
2016
Homo sapiens
Partridge, K.M.; Antonysamy, S.; Bhattachar, S.N.; Chandrasekhar, S.; Fisher, M.J.; Fretland, A.; Gooding, K.; Harvey, A.; Hughes, N.E.; Kuklish, S.L.; Luz, J.G.; Manninen, P.R.; McGee, J.E.; Mudra, D.R.; Navarro, A.; Norman, B.H.; Quimby, S.J.; Schiffler, M.A.; Sloan, A.V.; Warshawsky, A.M.; Weller, J.M.; Yor, Y.o.r.k.
Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1
Bioorg. Med. Chem. Lett.
27
1478-1483
2017
Homo sapiens (O14684), Homo sapiens
Muthukaman, N.; Tambe, M.; Deshmukh, S.; Pisal, D.; Tondlekar, S.; Shaikh, M.; Sarode, N.; Kattige, V.G.; Pisat, M.; Sawant, P.; Honnegowda, S.; Karande, V.; Kulkarni, A.; Behera, D.; Jadhav, S.B.; Sangana, R.R.; Gudi, G.S.; Khairatkar-Joshi, N.; Gharat, L.A.
Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors Part-1
Bioorg. Med. Chem. Lett.
27
5131-5138
2017
Homo sapiens (O14684)
Hansen, K.; Varvas, K.; Jaerving, I.; Samel, N.
Novel membrane-associated prostaglandin E synthase-2 from crustacean arthropods
Comp. Biochem. Physiol. B
174
45-52
2014
Caprella sp. KV-2010a (S4VIU3), Gammarus sp. KV-2010a (S4VLK7)
Li, D.; Howe, N.; Dukkipati, A.; Shah, S.T.; Bax, B.D.; Edge, C.; Bridges, A.; Hardwicke, P.; Singh, O.M.; Giblin, G.; Pautsch, A.; Pfau, R.; Schnapp, G.; Wang, M.; Olieric, V.; Caffrey, M.
Crystallizing membrane proteins in the lipidic mesophase. Experience with human prostaglandin E2 synthase 1 and an evolving strategy
Cryst. Growth Des.
14
2034-2047
2014
Homo sapiens (O14684), Homo sapiens
Eskilsson, A.; Tachikawa, M.; Hosoya, K.; Blomqvist, A.
Distribution of microsomal prostaglandin E synthase-1 in the mouse brain
J. Comp. Neurol.
522
3229-3244
2014
Mus musculus
Schiffler, M.A.; Antonysamy, S.; Bhattachar, S.N.; Campanale, K.M.; Chandrasekhar, S.; Condon, B.; Desai, P.V.; Fisher, M.J.; Groshong, C.; Harvey, A.; Hickey, M.J.; Hughes, N.E.; Jones, S.A.; Kim, E.J.; Kuklish, S.L.; Luz, J.G.; Norman, B.H.; Rathmell, R.E.; Rizzo, J.R.; Seng, T.W.; Thibodeaux, S.J.; Woods, T.A.
Discovery and characterization of 2-acylaminoimidazole microsomal prostaglandin E synthase-1 inhibitors
J. Med. Chem.
59
194-205
2016
Homo sapiens
Verhoff, M.; Seitz, S.; Paul, M.; Noha, S.M.; Jauch, J.; Schuster, D.; Werz, O.
Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E2 synthase-1
J. Nat. Prod.
77
1445-1451
2014
Homo sapiens
Bahia, M.S.; Katare, Y.K.; Silakari, O.; Vyas, B.; Silakari, P.
Inhibitors of microsomal prostaglandin E2 synthase-1 enzyme as emerging anti-inflammatory candidates
Med. Res. Rev.
34
825-855
2014
Homo sapiens
Werz, O.; Seegers, J.; Schaible, A.; Weinigel, C.; Barz, D.; Koeberle, A.; Allegrone, G.; Pollastro, F.; Zampieri, L.; Grassi, G.; Appendino, G.
Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase
PharmaNutrition
2
53-60
2014
Homo sapiens
-
Raouf, J.; Rafique, N.; Goodman, M.; Idborg, H.; Bergqvist, F.; Armstrong, R.; Jakobsson, P.; Morgenstern, R.; Spahiu, L.
Arg126 and Asp49 are essential for the catalytic function of microsomal prostaglandin E2 synthase 1 and Ser127 is not
PLoS ONE
11
e163600
2016
Homo sapiens (O14684)
Brock, J.S.; Hamberg, M.; Balagunaseelan, N.; Goodman, M.; Morgenstern, R.; Strandback, E.; Samuelsson, B.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase
Proc. Natl. Acad. Sci. USA
113
972-977
2016
Homo sapiens (O14684), Homo sapiens
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