5.3.99.3: prostaglandin-E synthase
This is an abbreviated version!
For detailed information about prostaglandin-E synthase, go to the full flat file.
Word Map on EC 5.3.99.3
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5.3.99.3
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cox-2
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cyclooxygenase
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arachidonic
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synthases
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prostanoids
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lipopolysaccharide
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tnf
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lps
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phospholipase
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eicosanoids
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lps-induced
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pain
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endometrium
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leukotriene
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prostacyclin
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thromboxane
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nsaids
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indomethacin
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pgf2alpha
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5-lipoxygenase
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il-1beta
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celecoxib
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nonsteroidal
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interleukin-1beta
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luteolysis
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luteal
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platinum
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15-pgdh
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estrous
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postictal
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medicine
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rhodium
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pencil
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palladium
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drug development
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6-keto-pgf1alpha
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automobile
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pghs-2
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prostaglandin-endoperoxide
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e-prostanoid
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ictal
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pge2-dependent
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l-pgds
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15-hydroxyprostaglandin
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lipocalin-type
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akr1b1
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cox-2-dependent
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6-keto
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coxibs
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6-keto-pgf1
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ptgds
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cox-derived
- 5.3.99.3
- cox-2
-
cyclooxygenase
-
arachidonic
- synthases
-
prostanoids
- lipopolysaccharide
- tnf
- lps
- phospholipase
-
eicosanoids
-
lps-induced
- pain
- endometrium
-
leukotriene
- prostacyclin
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thromboxane
-
nsaids
- indomethacin
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pgf2alpha
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5-lipoxygenase
- il-1beta
- celecoxib
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nonsteroidal
- interleukin-1beta
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luteolysis
- luteal
- platinum
- 15-pgdh
-
estrous
-
postictal
- medicine
-
rhodium
-
pencil
- palladium
- drug development
-
6-keto-pgf1alpha
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automobile
- pghs-2
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prostaglandin-endoperoxide
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e-prostanoid
-
ictal
-
pge2-dependent
- l-pgds
- 15-hydroxyprostaglandin
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lipocalin-type
- akr1b1
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cox-2-dependent
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6-keto
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coxibs
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6-keto-pgf1
- ptgds
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cox-derived
Reaction
Synonyms
CPGES, cPGES/p23, cytosolic prostaglandin E synthase, cytosolic prostaglandin E(2) synthase, cytosolic prostaglandin E(2) synthase-2, endoperoxide isomerase, Isomerase, prostaglandin R2 E-, membrane-associated PGE2 synthase, membrane-associated prostaglandin E synthase-2, membrane-associated prostaglandin E(2) synthase-1, membrane-associated prostaglandin E(2) synthase-2, microsomal PG synthase-1, microsomal PGE synthase-1, microsomal PGE2 synthase, microsomal PGE2 synthase-1, microsomal prostaglandin E synthase, microsomal prostaglandin E synthase 1, microsomal prostaglandin E synthase type 1, microsomal prostaglandin E synthase type 2, microsomal prostaglandin E synthase type-2, microsomal prostaglandin E synthase-1, microsomal prostaglandin E synthase-2, microsomal prostaglandin E(2) synthase-1, microsomal prostaglandin E(2) synthase-2, microsomal prostaglandin E2 synthase 1, microsomal prostaglandin E2 synthase type 1, microsomal prostaglandin E2 synthase-1, microsomal prostaglandin synthase-1, microsomal prostaglandin-E synthase-1, mPGE synthase-2, mPGES, mPGES-1, mPGES-2, MPGES1, MPGES2, p23, PGE, PGE isomerase, PGE synthase, PGE synthase-1, PGE2, PGE2 isomerase, PGE2 synthase, PGE2-synthase, PGES, PGES-1, PGES-2, PGH-PGE isomerase, PGH2/PGE2 isomerase, prostagandin-E synthetase, Prostaglandin E synthase, prostaglandin E synthase 1, prostaglandin E synthase type 2, prostaglandin E synthase-1, prostaglandin E synthase-2, Prostaglandin E2 isomerase, prostaglandin E2 synthase, prostaglandin E2 synthase-1, prostaglandin E2 synthase-I, Prostaglandin endoperoxide E isomerase, Prostaglandin endoperoxide E2 isomerase, Prostaglandin endoperoxide-E isomerase, Prostaglandin H-E isomerase, Prostaglandin H-prostaglandin E isomerase, Prostaglandin R-prostaglandin E isomerase, prostaglandin synthase-1, prostaglandin-E synthase, Prostaglandin-H2 E-isomerase, PTGES
ECTree
5.3.99.3 prostaglandin-E synthaseAdvanced search results
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results (Activating Compound
Activating Compound on EC 5.3.99.3 - prostaglandin-E synthase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
angiotensin II
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angiotension II infusion induces mRNA expression of mPGES-1, mPGES-2 and cytosolic PGE synthase
epigallocatechin gallate
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enhances COX-2 and isoform mPGES-1 gene expression and production of prostaglandin E2. Induction of mPGES-1 is mediated by active ERK1/2MAP kinases and early growth response gene 1
Hsp90
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maximal activity is achieved when the three components (cPGES, casein kinase II and Hsp90) are mixed at a molar proportion of 1:1:1
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lipopolysaccharide
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lipopolysaccharide binds to receptor TLR4 on osteoblasts that directly induces isoform mPGES-1 expression for prostaglandin E2 synthesis, leading to subsequent bone resorption
Tumor necrosis factor alpha
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increase in protein expression and activity of isoform mPGES-1, accompanied by increased COX-2 expression and production of prostaglandin E2
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dithiothreitol
leads to dissociation of the bound heme which is hindered by imidazole
GSH
the enzyme activity is increased in the presence of reduced glutathione
GSH
the enzyme activity is increased in the presence of reduced glutathione
GSH
mPGES2 has a GSH-binding motif, the GSH molecule binds at the predicted amino acid residues 148VPxL to 164DSxxI. GSH is essential for heme binding to isozyme mPGES2, structures of GSH-heme complex-binding cavity in isozyme mPGES2, overview
GSH
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concentrations below 0.5 mM are required for maximal activity of IgG1(hei-26)-reactive protein
GSH
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two different types of prostaglandin E synthase: 1. GSH-dependent enzyme, 2. GSH-independent enzyme. The genitally organs, especially the deferent duct have mainly GSH-dependent prostaglandin E synthase activity. Heart, spleen and uterus have only the GSH-independent activity. In absence of reduced glutathione the enzyme from deferent duct shows only 3% of the activity in presence of reduced glutathione
interleukin 1beta
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increase in protein expression and activity of isoform mPGES-1, accompanied by increased COX-2 expression and production of prostaglandin E2
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interleukin 1beta
induces isoform mPGES-1 and subsequent production of prostaglandin E2, while production of prostaglandin I2 is reduced by increased expression of mPGES-1
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interleukin 1beta
stimulates release of prostaglandin E2 by myometrical smooth muscle cells and increases COX-2 and mPGES-1 mRNA and protein expression
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additional information
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IL-1 administration into the mouse cortex leads to elevated expression of cPGES and an increase in prostaglandin E2
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additional information
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mPGES-1 expression is upregulated in COX-1 and COX-2 knock-out cells
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additional information
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phosphorylation is crucial for the enzyme's function, phosphorylation by casein kinase II enhances cPGES activity 3fold
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additional information
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lipopolysaccharide significantly increases the mRNA level of mPGES-1
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