4.1.3.44: tRNA 4-demethylwyosine synthase (AdoMet-dependent)
This is an abbreviated version!
For detailed information about tRNA 4-demethylwyosine synthase (AdoMet-dependent), go to the full flat file.
Word Map on EC 4.1.3.44
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4.1.3.44
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wybutosine
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decoding
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anticodon
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tricyclic
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guanosine
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codon-anticodon
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s-adenosyl-l-methionine
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5\'-deoxyadenosyl
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3'-position
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iron-sulfur
- 4.1.3.44
- wybutosine
-
decoding
-
anticodon
-
tricyclic
- guanosine
-
codon-anticodon
- s-adenosyl-l-methionine
-
5\'-deoxyadenosyl
-
3'-position
-
iron-sulfur
Reaction
Synonyms
4-demethylwyosine synthase, Taw1, tRNA wyosine derivatives biosynthesis protein Taw1, TYW1, YPL207W
ECTree
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Cofactor
Cofactor on EC 4.1.3.44 - tRNA 4-demethylwyosine synthase (AdoMet-dependent)
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Fe-S center
residues Cys81, Cys85 and Cys88 are predicted to comprise the iron-sulfur cluster. In the crystal structure, their side chains face each other to create the cluster site
[4Fe-4S]-center
the N-terminal half of the enzyme beside the radical-SAM cysteine triad, contains an additional highly conserved cysteine motif involved in the coordination of a second [4Fe-4S] cluster. This cluster displays a free coordination site that interacts with pyruvate, the second substrate of the reaction