4.1.3.44: tRNA 4-demethylwyosine synthase (AdoMet-dependent)

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For detailed information about tRNA 4-demethylwyosine synthase (AdoMet-dependent), go to the full flat file.

Reaction

Synonyms

4-demethylwyosine synthase, Taw1, tRNA wyosine derivatives biosynthesis protein Taw1, TYW1, YPL207W

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.44 tRNA 4-demethylwyosine synthase (AdoMet-dependent)

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Results	in table
4452	AA Sequence
4	Cloned(Commentary)
8	Cofactor
3	Crystallization (Commentary)
2	General Information
1	Metals/Ions
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
20	Organism
2	Pathway
1	PDB ID
1	pH Optimum
31	Protein Variants
4	Purification (Commentary)
1	Reaction
16	Reference
10	Substrates and Products (Substrate)
2	Subunits
18	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 4.1.3.44 - tRNA 4-demethylwyosine synthase (AdoMet-dependent)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine

4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O

6 entries

N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine

4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O

Methanocaldococcus jannaschii

-

-

747086

-

-

ir

N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine

4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O

Methanocaldococcus jannaschii

Q57705

-

747631

-

-

?

N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine

4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O

Methanocaldococcus jannaschii

Q57705

-

748046

-

-

ir

N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine

4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O

Methanocaldococcus jannaschii

Q57705

enzyme catalyzes the condensation of N-methylguanosine with two carbon atoms from pyruvate to form 4-demethylwyosine, which is a common intermediate in the biosynthesis of all of the hypermodified RNA bases related to wybutosine. C2 and C3 of pyruvate are incorporated while C1 is not

724300

-

-

?

N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine

4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O

Methanocaldococcus jannaschii ATCC 43067

Q57705

enzyme catalyzes the condensation of N-methylguanosine with two carbon atoms from pyruvate to form 4-demethylwyosine, which is a common intermediate in the biosynthesis of all of the hypermodified RNA bases related to wybutosine. C2 and C3 of pyruvate are incorporated while C1 is not

724300

-

-

?

N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine

4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O

Methanocaldococcus jannaschii DSM 2661

Q57705

-

748046

-

-

ir