4.1.3.44: tRNA 4-demethylwyosine synthase (AdoMet-dependent)

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For detailed information about tRNA 4-demethylwyosine synthase (AdoMet-dependent), go to the full flat file.

Reaction

Synonyms

4-demethylwyosine synthase, Taw1, tRNA wyosine derivatives biosynthesis protein Taw1, TYW1, YPL207W

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.44 tRNA 4-demethylwyosine synthase (AdoMet-dependent)

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Results	in table
4452	AA Sequence
4	Cloned(Commentary)
8	Cofactor
3	Crystallization (Commentary)
2	General Information
1	Metals/Ions
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
20	Organism
2	Pathway
1	PDB ID
1	pH Optimum
31	Protein Variants
4	Purification (Commentary)
1	Reaction
16	Reference
10	Substrates and Products (Substrate)
2	Subunits
18	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 4.1.3.44 - tRNA 4-demethylwyosine synthase (AdoMet-dependent)

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SYSTEMATIC NAME

IUBMB Comments

tRNAPhe N1-methylguanine,pyruvate acetaldehyde-lyase (tRNAPhe 4-demethylwyosine-forming, decarboxylating, dehydrating)

This enzyme, which is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes, binds two [4Fe-4S] clusters [3,4]. Carbons C2 and C3 from pyruvate are incorporated into 4-demethylwyosine [3]. The enzyme is found in eukaryotes where it is part of the pathway for wybutosine synthesis, and in archaea, where it is involved in the biosynthesis of archaeal wye bases, such as wyosine, isowyosine, and methylwyosine.