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4.1.3.17: 4-hydroxy-4-methyl-2-oxoglutarate aldolase

This is an abbreviated version!
For detailed information about 4-hydroxy-4-methyl-2-oxoglutarate aldolase, go to the full flat file.

Word Map on EC 4.1.3.17

Reaction

2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
=
oxaloacetate
+
pyruvate

Synonyms

4-hydroxy-4-methyl-2-ketoglutarate aldolase, 4-hydroxy-4-methyl-2-oxoglutarate aldolase, 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, aldolase, 4-hydroxy-4-methyl-2-oxoglutarate, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, HMG aldolase, HMG/CHA aldolase, KDPG aldolase, MHK aldolase, MHKG aldolase, pyruvate aldolase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Inhibitors

Inhibitors on EC 4.1.3.17 - 4-hydroxy-4-methyl-2-oxoglutarate aldolase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxoadipate
-
competitive with respect to DL-4-carboxy-4-hydroxy-2-oxoadipate
2-oxobutanoate
-
competitive with respect to DL-4-carboxy-4-hydroxy-2-oxoadipate
2-oxoglutarate
4-hydroxy-2-oxobutyrate
-
competitive with respect to DL-4-carboxy-4-hydroxy-2-oxoadipate
ATP
-
competitive
citrate
-
competitive
diethyl dicarbonate
-
not reversed by hydroxylamine, L-4-carboxy-4-hydroxy-2-oxoadipate strongly protects against inactivation
DL-4-hydroxy-2-oxovalerate
-
competitive with respect to DL-4-carboxy-4-hydroxy-2-oxoadipate
HgCl2
-
0.1 mM, 41% inhibition
NEM
-
1 mM, 10% inhibition
oxalate
oxaloacetate
-
competitive
PCMB
-
1 mM, 48% inhibition
pyruvate
-
-
pyruvic aldol lactone
-
-
-