4.1.3.17: 4-hydroxy-4-methyl-2-oxoglutarate aldolase

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For detailed information about 4-hydroxy-4-methyl-2-oxoglutarate aldolase, go to the full flat file.

Reaction

Synonyms

4-hydroxy-4-methyl-2-ketoglutarate aldolase, 4-hydroxy-4-methyl-2-oxoglutarate aldolase, 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, aldolase, 4-hydroxy-4-methyl-2-oxoglutarate, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, HMG aldolase, HMG/CHA aldolase, KDPG aldolase, MHK aldolase, MHKG aldolase, pyruvate aldolase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase

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Results	in table
3	Activating Compound
10314	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
6	General Information
20	Inhibitors
34	kcat/KM [mM/s]
4	Ki Value [mM]
52	KM Value [mM]
31	Metals/Ions
9	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
106	Organism
11	Pathway
1	PDB ID
20	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
11	Protein Variants
7	Purification (Commentary)
2	Reaction
1	Reaction Type
17	Reference
2	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
49	Substrates and Products (Substrate)
6	Subunits
18	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
35	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.1.3.17 - 4-hydroxy-4-methyl-2-oxoglutarate aldolase

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SYSTEMATIC NAME

IUBMB Comments

4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)

Requires a divalent metal ion [3]. This enzyme participates in the degradation of 3,4-dihydroxybenzoate (via the meta-cleavage pathway), phthalate, syringate and 3,4,5-trihydroxybenzoate [1-3]. The enzyme from Pseudomonas straminea can also catalyse the activity of EC 4.1.3.16, 4-hydroxy-2-oxoglutarate aldolase, and the decarboxylation of oxaloacetate [3].