4.1.3.17: 4-hydroxy-4-methyl-2-oxoglutarate aldolase
This is an abbreviated version!
For detailed information about 4-hydroxy-4-methyl-2-oxoglutarate aldolase, go to the full flat file.
Word Map on EC 4.1.3.17
Reaction
Synonyms
4-hydroxy-4-methyl-2-ketoglutarate aldolase, 4-hydroxy-4-methyl-2-oxoglutarate aldolase, 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, aldolase, 4-hydroxy-4-methyl-2-oxoglutarate, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, HMG aldolase, HMG/CHA aldolase, KDPG aldolase, MHK aldolase, MHKG aldolase, pyruvate aldolase
ECTree
4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.1.3.17 - 4-hydroxy-4-methyl-2-oxoglutarate aldolase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-hydroxy-4-methyl-2-oxoglutarate
pyruvate
-
involved in biosynthesis of gamma-substituted glutamic acid, participates in the alpha-keto acid pathway for degradation of the meta-fission product of protocatechuate, in Pseudomonas ochraceae grown on phthalate the physiolological substrate is not hydroxymethyl glutamic acid but CHA, L-4-carboxy-4-hydroxy-2-oxoadipate, which is cleaved to pyruvate and oxaloacetate
-
r
4-carboxy-4-hydroxy-2-oxoadipate
pyruvate + oxaloacetate
-
the L-isomer is preferred
-
?
4-carboxy-4-hydroxy-2-oxoadipate
pyruvate + oxaloacetate
-
no equilibrium due to oxaloacetate beta-decarboxylase activity associated with the enzyme
-
?
4-carboxy-4-hydroxy-2-oxoadipate
pyruvate + oxaloacetate
-
L-4-carboxy-4-hydroxy-2-oxoadipate or D-4-carboxy-4-hydroxy-2-oxoadipate
-
?
4-Hydroxy-2-oxoglutarate
Pyruvate + glyoxylate
-
the L-isomer is preferred
-
?
4-hydroxy-4-methyl-2-oxoglutarate
2 pyruvate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
-
?
4-hydroxy-4-methyl-2-oxoglutarate
pyruvate + pyruvate
-
preferentially attacks the R-form of 4-hydroxy-4-methyl-2-oxoglutarate
-
?
4-hydroxy-4-methyl-2-oxoglutarate
pyruvate + pyruvate
-
the enzyme attacks only one enantiomer
-
?
4-hydroxy-4-methyl-2-oxoglutarate
pyruvate + pyruvate
-
the L-isomer is preferred
-
?
D-4-carboxy-4-hydroxy-2-oxoadipate
pyruvate + oxaloacetate
-
-
-
?
D-4-carboxy-4-hydroxy-2-oxoadipate
pyruvate + oxaloacetate
-
-
-
?
DL-4-carboxy-4-hydroxy-2-oxoadipate
pyruvate + oxaloacetate
-
-
-
?
DL-4-carboxy-4-hydroxy-2-oxoadipate
pyruvate + oxaloacetate
-
-
-
?
l-4-carboxy-4-hydroxy-2-oxoadipate
pyruvate + oxaloacetate
-
-
-
?
l-4-carboxy-4-hydroxy-2-oxoadipate
pyruvate + oxaloacetate
-
-
-
?
additional information
?
-
-
the enzyme is a class II, divalent metal ion-dependent, pyruvate aldolase that catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate and 4-carboxy-4-hydroxy-2-oxoadipate into two molecules of pyruvate in the former and a molecule of each pyruvate and oxaloacetate in the latter, cf. 4-carboxy-4-hydroxy-2-oxoadipate aldolase, EC 4.1.3. The enzyme also contains a secondary oxaloacetate decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retroaldol and decarboxylase reactions
-
-
?
additional information
?
-
-
inducible by aromatic carboxylates such as phthalate
-
-
?
additional information
?
-
-
the RNAse E activity A-like protein Yer010Cp from Saccharomyces cerevisiae S288C contains HMG aldolase and oxaloacetate decarboxylase activities
-
-
?
additional information
?
-
-
the RNAse E activity A-like protein TtRraA from Thermus thermophilus HB8 contains HMG aldolase and oxaloacetate decarboxylase activities
-
-
?
additional information
?
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
the RNAse E activity A-like protein TtRraA from Thermus thermophilus HB8 contains HMG aldolase and oxaloacetate decarboxylase activities
-
-
?
