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4.1.3.17: 4-hydroxy-4-methyl-2-oxoglutarate aldolase

This is an abbreviated version!
For detailed information about 4-hydroxy-4-methyl-2-oxoglutarate aldolase, go to the full flat file.

Word Map on EC 4.1.3.17

Reaction

2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
=
oxaloacetate
+
pyruvate

Synonyms

4-hydroxy-4-methyl-2-ketoglutarate aldolase, 4-hydroxy-4-methyl-2-oxoglutarate aldolase, 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, aldolase, 4-hydroxy-4-methyl-2-oxoglutarate, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, HMG aldolase, HMG/CHA aldolase, KDPG aldolase, MHK aldolase, MHKG aldolase, pyruvate aldolase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Natural Substrates Products

Natural Substrates Products on EC 4.1.3.17 - 4-hydroxy-4-methyl-2-oxoglutarate aldolase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-carboxy-4-hydroxy-2-oxoadipate
oxaloacetate + pyruvate
show the reaction diagram
-
-
-
r
4-hydroxy-4-methyl-2-oxoglutarate
2 pyruvate
show the reaction diagram
4-hydroxy-4-methyl-2-oxoglutarate
pyruvate
show the reaction diagram
-
involved in biosynthesis of gamma-substituted glutamic acid, participates in the alpha-keto acid pathway for degradation of the meta-fission product of protocatechuate, in Pseudomonas ochraceae grown on phthalate the physiolological substrate is not hydroxymethyl glutamic acid but CHA, L-4-carboxy-4-hydroxy-2-oxoadipate, which is cleaved to pyruvate and oxaloacetate
-
r
l-4-carboxy-4-hydroxy-2-oxoadipate
pyruvate + oxaloacetate
show the reaction diagram
additional information
?
-