4.1.1.21: phosphoribosylaminoimidazole carboxylase

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For detailed information about phosphoribosylaminoimidazole carboxylase, go to the full flat file.

Reaction

Synonyms

5-Amino-1-ribosylimidazole 5-phosphate carboxylase, 5-Phosphoribosyl-5-aminoimidazole carboxylase, AdeD, AIR carboxylase, AIRC, aminoimidazole ribonucleotide carboxylase, Carboxylyase, phosphoribosylaminoimidazole, class II PurE, PAICS, phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, PurE

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.21 phosphoribosylaminoimidazole carboxylase

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Results	in table
3213	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
4	Crystallization (Commentary)
1	General Stability
1	IC50 Value
11	Inhibitors
2	kcat/KM [mM/s]
7	Ki Value [mM]
5	KM Value [mM]
13	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
139	PDB ID
1	pH Stability
2	pI Value
4	Protein Variants
7	Purification (Commentary)
1	Reaction
2	Reaction Type
21	Reference
5	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
24	Substrates and Products (Substrate)
7	Subunits
13	Synonyms
1	Systematic Name
1	Temperature Stability [°C]
4	Turnover Number [1/s]

Engineering

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Engineering on EC 4.1.1.21 - phosphoribosylaminoimidazole carboxylase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

E177K

Cricetulus griseus

M1R995

mutation identified in PAICS gene of AdeD cell, located in alpha4. Mutation impacts protein structure and completely abolishes its biosynthesis

728311

I237V

Cricetulus griseus

M1R995

mutation identified in PAICS gene of AdeD cell, located in the loop between beta14 and alpha5

728311

W363?

Cricetulus griseus

M1R995

mutation identified in PAICS gene of AdeD cell, located in alpha9. Mutation impacts protein structure and completely abolishes its biosynthesis

728311

T40N

Treponema denticola

Q73PV9

the specific actzivity of the mutant is 20000fold lower than that of wild type enzyme

714253