4.1.1.21: phosphoribosylaminoimidazole carboxylase

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For detailed information about phosphoribosylaminoimidazole carboxylase, go to the full flat file.

Reaction

Synonyms

5-Amino-1-ribosylimidazole 5-phosphate carboxylase, 5-Phosphoribosyl-5-aminoimidazole carboxylase, AdeD, AIR carboxylase, AIRC, aminoimidazole ribonucleotide carboxylase, Carboxylyase, phosphoribosylaminoimidazole, class II PurE, PAICS, phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, PurE

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.21 phosphoribosylaminoimidazole carboxylase

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Results	in table
3213	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
4	Crystallization (Commentary)
1	General Stability
1	IC50 Value
11	Inhibitors
2	kcat/KM [mM/s]
7	Ki Value [mM]
5	KM Value [mM]
13	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
139	PDB ID
1	pH Stability
2	pI Value
4	Protein Variants
7	Purification (Commentary)
1	Reaction
2	Reaction Type
21	Reference
5	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
24	Substrates and Products (Substrate)
7	Subunits
13	Synonyms
1	Systematic Name
1	Temperature Stability [°C]
4	Turnover Number [1/s]

Crystallization

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Crystallization on EC 4.1.1.21 - phosphoribosylaminoimidazole carboxylase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

recombinant protein expressed in Escherichia coli

Bacillus anthracis

-

666877

protein sequence is used in model building on Trchoderma ni enzyme crystals providing an excellent fit to the electron density. Comparison to the structure of human enzyme

Bombyx mori

Q1HQ66

728777

hanging drop vapor diffusion method, using 14-16% (w/v) PEG 1000, 100 mM MgCl2, and 100 mM imidazole (pH 8.0)

Treponema denticola

Q73PV9

714253

to 2.8 A resolution, space-group P22121 with one homo-tetramer in the asymmetric unit. Comparison to the structure of human enzyme

Trichoplusia ni

-

728777