Information on EC 4.1.1.21 - phosphoribosylaminoimidazole carboxylase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
4.1.1.21
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RECOMMENDED NAME
GeneOntology No.
phosphoribosylaminoimidazole carboxylase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
carboxylation
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decarboxylation
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PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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inosine-5'-phosphate biosynthesis II
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Metabolic pathways
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Purine metabolism
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SYSTEMATIC NAME
IUBMB Comments
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5-Amino-1-ribosylimidazole 5-phosphate carboxylase
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5-Phosphoribosyl-5-aminoimidazole carboxylase
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AIR carboxylase
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AIR carboxylase
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AIR carboxylase
Q73PV9
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AIRC
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aminoimidazole ribonucleotide carboxylase
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Carboxylyase, phosphoribosylaminoimidazole
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class II PurE
Q73PV9
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PurE
Q73PV9
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CAS REGISTRY NUMBER
COMMENTARY
9032-04-6
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
two enzymes PurK and PurE are required for the reaction
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Manually annotated by BRENDA team
bifunctional enzyme: phosphoribosylaminoimidazole carboxylase/4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase, with two independent folding domains, each containing a different catalytic site
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Manually annotated by BRENDA team
Pigeon
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Manually annotated by BRENDA team
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
3-nitro-1-(beta-D-ribofuranosyl)pyrrole 5'-phosphate
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4-nitro-1-(-beta-D-ribofuranosyl)pyrazole 5'-phosphate
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4-nitro-1-(beta-D-ribofuranosyl)imidazole 5'-phosphate
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4-Nitro-5-aminoimidazole ribonucleotide
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steady-state inhibitor
4-Nitro-5-aminoimidazole ribonucleotide
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tight-binding inhibitor
4-Nitro-5-aminoimidazole ribonucleotide
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slow, tight binding inhibitor
5-Amino-1(5'-phospho-beta-D-ribofuranosyl)-4-nitroimidazole
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5-amino-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxylate 5'-phosphate
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5-amino-1-(beta-D-ribofuranosyl)-4-nitropyrazole 5'-phosphate
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5-amino-1-(beta-D-ribofuranosyl)imidazole-4-carboxaldehyde 5'-phosphate
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5-amino-1-(beta-D-ribofuranosyl)pyrazole-4-carboxylate 5'-phosphate
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Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.022
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4-nitro-1-(-beta-D-ribofuranosyl)pyrazole 5'-phosphate
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in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.0013
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4-nitro-1-(beta-D-ribofuranosyl)imidazole 5'-phosphate
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in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.00000034
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4-Nitro-5-aminoimidazole ribonucleotide
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in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.0028
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5-amino-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxylate 5'-phosphate
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in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.00039
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5-amino-1-(beta-D-ribofuranosyl)-4-nitropyrazole 5'-phosphate
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in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.062
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5-amino-1-(beta-D-ribofuranosyl)imidazole-4-carboxaldehyde 5'-phosphate
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in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.006
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5-amino-1-(beta-D-ribofuranosyl)pyrazole-4-carboxylate 5'-phosphate
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in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.1
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3-nitro-1-(beta-D-ribofuranosyl)pyrrole 5'-phosphate
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IC50 above 0.1 mM
PDB
SCOP
CATH
ORGANISM
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Bacillus anthracis (strain A0248)
Bacillus anthracis (strain A0248)
Bacillus anthracis (strain A0248)
Bacillus anthracis (strain A0248)
Bacillus anthracis (strain A0248)
Burkholderia ambifaria (strain MC40-6)
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
prolonged dialysis of more than 12 h, results in 50% loss of activity
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STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
4°C, stable for at least 6 months
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