4.1.1.21: phosphoribosylaminoimidazole carboxylase

This is an abbreviated version!
For detailed information about phosphoribosylaminoimidazole carboxylase, go to the full flat file.

Reaction

Synonyms

5-Amino-1-ribosylimidazole 5-phosphate carboxylase, 5-Phosphoribosyl-5-aminoimidazole carboxylase, AdeD, AIR carboxylase, AIRC, aminoimidazole ribonucleotide carboxylase, Carboxylyase, phosphoribosylaminoimidazole, class II PurE, PAICS, phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, PurE

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.21 phosphoribosylaminoimidazole carboxylase

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Results	in table
3213	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
4	Crystallization (Commentary)
1	General Stability
1	IC50 Value
11	Inhibitors
2	kcat/KM [mM/s]
7	Ki Value [mM]
5	KM Value [mM]
13	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
139	PDB ID
1	pH Stability
2	pI Value
4	Protein Variants
7	Purification (Commentary)
1	Reaction
2	Reaction Type
21	Reference
5	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
24	Substrates and Products (Substrate)
7	Subunits
13	Synonyms
1	Systematic Name
1	Temperature Stability [°C]
4	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.1.1.21 - phosphoribosylaminoimidazole carboxylase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

11 entries

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

?

4 entries

4-carboxy-5-aminoimidazole ribonucleotide + H+

5-aminoimidazole ribonucleotide + CO2

Treponema denticola

Q73PV9

-

714253

-

-

r

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

5-amino-1-(5-phospho-D-ribosyl)imidazole + carbon dioxide

Zygosaccharomyces rouxii

Q9UVE6

-

654019

-

654019

?

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2

4 entries

5-aminoimidazole ribonucleotide + CO2

4-carboxy-5-aminoimidazole ribonucleotide + H+

Treponema denticola

Q73PV9

-

714253

-

-

r

additional information

?

-

3 entries

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Bacillus subtilis

-

-

1259

-

1259

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Bacillus subtilis

-

-

1306

-

1306

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Escherichia coli

-

-

1268

-

1268

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Escherichia coli

-

PurK accelerates the growth of the organism by coupling ATP hydrolysis to HCO3-activation and subsequent N-carboxylation of 1-(5-phosphoribosyl)-5-aminoimidazole

4135

-

4135

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Gallus gallus

-

-

1263

-

1263

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Gallus gallus

-

-

4133

-

4133

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Gallus gallus

-

-

4136

-

4136

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Gallus gallus

-

-

702670

-

-

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Gallus gallus

-

1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate is formed directly from 1-(5-phosphoribosyl)-5-aminoimidazole + CO2

4135

-

4135

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Ovis aries

-

-

4137

-

4137

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate

Pigeon

-

-

1403

-

1403

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

?

Bacillus subtilis

-

enzyme of the de novo purine biosynthesis

1306

-

-

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

?

Escherichia coli

-

sixth step in the purine biosynthetic pathway

1268

-

-

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

?

Gallus gallus

-

enzyme in the biosynthetic pathway to AMP

1263

-

-

?

1-(5-Phosphoribosyl)-5-aminoimidazole + CO2

?

Pigeon

-

enzyme of the de novo purine biosynthesis

1403

-

-

?

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2

Candida albicans

Q92210

-

654019

-

654019

?

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2

Ogataea methanolica

Q01930

-

654019

-

654019

?

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2

Saccharomyces cerevisiae

P21264

-

654019

-

654019

?

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2

Schizosaccharomyces pombe

P15567

-

654019

-

654019

?

additional information

?

-

Gallus gallus

-

AIR carboxylase cannot use N5-carboxyaminoimidazole ribonucleotide, 5-amino-1-(beta-D-ribofuranosyl)pyrazole-4-carboxylate 5'-phosphate, and 5-amino-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxylate 5'-phosphate as substrates

702670

-

-

?

additional information

?

-

Treponema denticola

Q73PV9

the enzyme does not bind N5-carboxy-4-carboxy-5-aminoimidazole ribonucleotide

714253

-

-

?

additional information

?

-

Treponema denticola

-

the enzyme does not bind N5-carboxy-4-carboxy-5-aminoimidazole ribonucleotide

714253

-

-

?