Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.8.1.5: haloalkane dehalogenase

This is an abbreviated version!
For detailed information about haloalkane dehalogenase, go to the full flat file.

Word Map on EC 3.8.1.5

Reaction

1-Haloalkane
+
H2O
=
a primary alcohol
 +
halide

Synonyms

1,3,4,6,-tetrachloro-1,4-cyclohexadiene halidohydrolase, 1-chlorohexane halidohydrolase, 1-haloalkane dehalogenase, DadB, DatA, DbeA, DbjA, DccA, DhaA, DhaA31, DhaB, DhaC, DhAf, DhlA, DhmA, DmaA, dmbA, DmbB, DmbC, dmlA, DmmA, DmrA, DmrB, DmsA, DmtA, DmxA, DpcA, DppA, DrbA, DsaA, DspA, EC 3.8.1.1, eHLD-B, eHLD-C, haloalkane dehalogenase, haloalkane dehalogenase LinB, HanR, HLD, HLD-I, LinB, LinBMI, LinBUT, metallo-haloalkane dehalogenase, protein XP_504164, Rv2579, Ylehd

ECTree

     3 Hydrolases
         3.8 Acting on halide bonds
             3.8.1 In carbon-halide compounds
                3.8.1.5 haloalkane dehalogenase

Inhibitors

Inhibitors on EC 3.8.1.5 - haloalkane dehalogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-Dichloroethane
1,2-dichloropropane
-
competitive to 1-chlorobutane
1,3-dibromopropane
-
substrate inhibition
1-(4-oxo-4-phenylbutyl)-1H-1,2,4-triazole-3-carbonitrile
-
1-[(4-oxo-1,9a-dihydro-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl]-1H-1,2,4-triazole-3-carbonitrile
-
1-[4-[(2H-1,3-benzodioxol-5-yl)oxy]but-2-yn-1-yl]-4-(4-methoxyphenyl)piperazine
-
2,5-dimethyl-N-[1-[3-(trifluoromethyl)phenyl]ethyl]-1H-pyrrole-3-carboxamide
-
2-([methyl[(5-methyl-1,2-oxazol-3-yl)methyl]amino]methyl)quinazolin-4(3H)-one
-
2-oxo-N-[3-(1H-pyrazol-5-yl)phenyl]-1,2,3,4-tetrahydroquinoline-6-carboxamide
-
2-phenyl-5-(4H-1,2,4-triazol-4-yl)-1,3-benzoxazole
-
3-(morpholin-4-yl)propane-1-sulfonic acid
phosphate and MOPS buffers repress the enzyme activity
3-chloro-2-methylpropene
-
substrate inhibition
4-hydroxymercuribenzoate
-
weak
5-bromo-N-[[4-(1H-pyrazol-5-yl)phenyl]methyl]furan-2-carboxamide
-
5-[(tetrazolo[1,5-b]pyridazin-6-yl)amino]-1,3-dihydro-2H-benzimidazol-2-one
-
6-[(2-phenylpyrimidin-5-yl)oxy]tetrazolo[1,5-b]pyridazine
-
6-[5-(3-chlorophenyl)-2H-tetrazol-2-yl]-1,2,3,8a-tetrahydrotetrazolo[1,5-b]pyridazine
-
Ag2+
1-5 mM, strong inhibition
Co2+
1-5 mM, strong inhibition
Cu2+
1-5 mM, strong inhibition
CuSO4
cyano(quinolin-3-yl)methyl benzoate
-
Dibromomethane
-
-
Dichloromethane
-
-
ethyl 4-oxo-3-phenyl-3,4-dihydropyrazolo[5,1-d][1,2,3,5]tetrazine-8-carboxylate
-
Fe2+
1-5 mM, complete inhibition
Fe3+
1-5 mM, complete inhibition
halide
Hg2+
1-5 mM, strong inhibition
HgCl2
Mn2+
1-5 mM, strong inhibition
N-cyclohexyl-2-aminoethanesulfonic acid
CHES, competitive inhibition, CHES binds to the active site of DatA, the sulfate moiety of CHES is bound by Asn43, and the other parts are bound by Asp108 and His274 of the catalytic triad
N-methyl-N-[(4-oxo-1,4-dihydroquinazolin-2-yl)methyl]-2-(1H-1,2,4-triazol-1-yl)acetamide
-
N-[(furan-2-yl)methyl]-3-phenyl-1,2,4-oxadiazole-5-carboxamide
-
N-[2-(1H-imidazol-1-yl)ethyl]-6-phenylpyridazin-3-amine
-
N-[[4-(pyrrolidin-1-yl)phenyl]methyl]-4H-1,2,4-triazol-4-amine
-
Ni2+
1-5 mM, complete inhibition
Pb2+
1-5 mM, strong inhibition
Phenylmercuriacetate
-
-
phosphate
phosphate and MOPS buffers repress the enzyme activity
SDS
76% inhibition at 1%, 94% at 5%
Triton X100
35% inhibition at 1%, 83% at 5%
Tween 80
26% inhibition at 1%, 75% at 5%
Urea
79% inhibitin at 4 M, 93% at 8 M
Zn2+
1-5 mM, complete inhibition
additional information
-