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3.7.1.3: kynureninase

This is an abbreviated version!
For detailed information about kynureninase, go to the full flat file.

Word Map on EC 3.7.1.3

Reaction

L-kynurenine
+
H2O
=
anthranilate
 +
L-alanine

Synonyms

HsKynase, Kynase, KYNU, kynureninase, L-kynurenine hydrolase, PfKynase

ECTree

     3 Hydrolases
         3.7 Acting on carbon-carbon bonds
             3.7.1 In ketonic substances
                3.7.1.3 kynureninase

KI Value

KI Value on EC 3.7.1.3 - kynureninase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.01
(2S)-2-amino-4-oxo-4-phenylbutanoic acid
-
reaction of L-kynurenine with the enzyme
0.000055
(4R)-5-bromodihydro-L-kynurenine
-
-
0.00017
(4S)-5-bromodihydro-L-kynurenine
-
-
0.0003
(S)-(2-amino-4-bromophenyl)-L-cysteine S,S-dioxide
-
-
0.0004
(S)-(2-amino-5-bromophenyl)-L-cysteine S,S-dioxide
-
-
0.000027
(S)-(2-aminophenyl)-L-cysteine S,S-dioxide
-
-
0.005 - 0.022
2-amino-(4-oxo-4-naphthyl)-butyric acid
0.175
2-amino-4-(3-methoxyphenyl)-4-oxobutanoic acid
-
-
0.00025
3,5-dihydroxydeaminokynurenine
-
-
0.0001
3,7-dihydroxy-deamino-DL-kynurenine
-
pH 7.9, at 37ºC
0.000005 - 0.0001
3-hydroxydeaminokynurenine
0.01 - 0.015
3-methoxydeaminokynurenine
0.17 - 0.227
amino-(1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)-acetic acid
0.0349 - 0.045
amino-(1-oxo-2,3-dihydro-1H-inden-2-yl)-acetic acid
0.077 - 0.162
amino-(4-oxo-3,4-dihydro-2H-chromen-3-yl)-acetic acid
0.01
beta-benzoyl-L-alanine
-
at 25ºC, pH 7.8
0.012
D-kynurenine
0.012
deaminokynurenine
-
-
0.02 - 0.055
L-kynurenine
0.00003 - 0.00092
S-(2-aminophenyl)-L-cysteine dioxide