Information on EC 3.7.1.3 - kynureninase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
3.7.1.3
-
RECOMMENDED NAME
GeneOntology No.
kynureninase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
L-kynurenine + H2O = anthranilate + L-alanine
show the reaction diagram
aldol and retro-aldol reactions; A pyridoxal-phosphate protein.; a pyridoxal-phosphate protein. Also acts on 3'-hydroxykynurenine and some other (3-acrylcarbonyl)-alanines, hydrolytic beta,gamma-cleavage of aryl-substituted gamma-keto-alpha-amino acids
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Metabolic pathways
-
tryptophan degradation I (via anthranilate)
-
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
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tryptophan degradation XI (mammalian, via kynurenine)
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Tryptophan metabolism
-
SYSTEMATIC NAME
IUBMB Comments
L-kynurenine hydrolase
A pyridoxal-phosphate protein. Also acts on 3'-hydroxy-L-kynurenine and some other (3-arylcarbonyl)-alanines.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Kynase
-
-
KYNU
B7XB98
-
kynureninase
-
-
kynureninase
Q16719
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L-kynurenine hydrolase
-
-
-
-
L-kynurenine hydrolase
-
-
L-kynurenine hydrolase
-
-
L-kynurenine hydrolase
-
-
L-kynurenine hydrolase
-
-
L-kynurenine hydrolase
-
-
L-kynurenine hydrolase
-
-
CAS REGISTRY NUMBER
COMMENTARY
9024-78-6
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
strain ATCC 19213
-
-
Manually annotated by BRENDA team
strain red blood
UniProt
Manually annotated by BRENDA team
constitutive and inducible enzyme
-
-
Manually annotated by BRENDA team
male normolipidemic and diet-induced hyperlipidemic New Zealand rabbits; male Watanabe heritable hyperlipidemic rabbits
-
-
Manually annotated by BRENDA team
constitutive enzyme
-
-
Manually annotated by BRENDA team
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
kcat/KM VALUE [1/mMs-1]
kcat/KM VALUE [1/mMs-1] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
12
-
2-amino-4-(2-chlorophenyl)-4-oxobutanoic acid
-
at 37C in 0.04 M potassium phosphate, pH 7.8
0
1.4
-
2-amino-4-(2-methoxyphenyl)-4-oxobutanoic acid
-
at 37C in 0.04 M potassium phosphate, pH 7.8
0
1.6
-
2-amino-4-(4-methoxyphenyl)-4-oxobutanoic acid
-
at 37C in 0.04 M potassium phosphate, pH 7.8
0
1.7
-
2-fluorobenzoyl-DL-alanine
-
at 37C in 0.04 M potassium phosphate, pH 7.8
0
18
-
beta-(4-chlorobenzoyl)-DL-alanine
-
at 37C in 0.04 M potassium phosphate, pH 7.8
0
28
-
beta-(4-methylbenzoyl)-DL-alanine
-
at 37C in 0.04 M potassium phosphate, pH 7.8
0
0.019
-
beta-(4-trifluoromethylbenzoyl)-DL-alanine
-
at 37C in 0.04 M potassium phosphate, pH 7.8
0
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE