Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.7.1.3 extracted from

  • Tanizawa, K.; Soda, K.
    Inducible and constitutive kynureninases. Control of the inducible enzyme activity by transamination and inhibition of the constitutive enzyme by 3-hydroxyanthranilate (1979), J. Biochem., 86, 499-508.
    View publication on PubMed
Search for more literature for 3.7.1.3

Activating Compound

Activating Compound Comment Organism Structure
pyridoxal 5'-phosphate
-
 Sus scrofa
pyridoxal 5'-phosphate in the presence of pyruvate Neurospora crassa
pyridoxamine phosphate in the presence of pyruvate Neurospora crassa

Application

Application Comment Organism
medicine tryptophan metabolism Sus scrofa
medicine tryptophan metabolism Neurospora crassa

Inhibitors

Inhibitors Comment Organism Structure
3-Hydroxyanthranilate 0.001 mM in 0.06 mM Tris-HCl buffer Sus scrofa
anthranilic acid
-
 Neurospora crassa
delta-N-acetyl-L-ornithine 0.001 mM in 0.06 mM Tris-HCl buffer Neurospora crassa
Kynurenate
-
 Neurospora crassa
Kynurenate 0.001 mM in 0.06 mM Tris-HCl buffer Sus scrofa
L-alanine
-
 Neurospora crassa
L-lysine
-
 Neurospora crassa
L-ornithine
-
 Neurospora crassa
quinaldinate
-
 Neurospora crassa
quinaldinate 0.001 mM in 0.06 mM Tris-HCl buffer Sus scrofa
S-(beta-aminoethyl)-L-cysteine 0.001 mM in 0.06 mM Tris-HCl buffer Neurospora crassa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
11
-
 L-alanine
-
 Neurospora crassa
40
-
 L-ornithine
-
 Neurospora crassa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
105000
-
-
 Neurospora crassa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-kynurenine + H2O Sus scrofa
-
 anthranilate + L-alanine
-
 ?
L-kynurenine + H2O Neurospora crassa
-
 anthranilate + L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-
Sus scrofa
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
12.56
-
-
 Neurospora crassa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + H2O
-
 Sus scrofa anthranilate + L-alanine
-
 ?
L-kynurenine + H2O
-
 Neurospora crassa anthranilate + L-alanine
-
 ?
L-ornithine + H2O
-
 Neurospora crassa ?
-
 ?