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3.7.1.3: kynureninase

This is an abbreviated version!
For detailed information about kynureninase, go to the full flat file.

Word Map on EC 3.7.1.3

Reaction

L-kynurenine
+
H2O
=
anthranilate
 +
L-alanine

Synonyms

HsKynase, Kynase, KYNU, kynureninase, L-kynurenine hydrolase, PfKynase

ECTree

     3 Hydrolases
         3.7 Acting on carbon-carbon bonds
             3.7.1 In ketonic substances
                3.7.1.3 kynureninase

Reference

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Reference on EC 3.7.1.3 - kynureninase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stevens, J.L.
Isolation and characterization of a rat liver enzyme with both cysteine conjugate beta-lyase and kynureninase activity
J. Biol. Chem.
260
7945-7950
1985
Rattus norvegicus
Manually annotated by BRENDA team
Jacoby, W.B.; Bonner, D.M.
Kynureninase from Neurospora: Interaction of enzyme with substrates, coenzyme, and amines
J. Biol. Chem.
205
709-715
1953
Neurospora crassa
Manually annotated by BRENDA team
Jacoby, W.B.; Bonner, D.M.
Kynureninase from Neurospora: Purification and properties
J. Biol. Chem.
205
699-707
1953
Neurospora crassa
Manually annotated by BRENDA team
Knox, W.E.
The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency
Biochem. J.
53
379-385
1952
Rattus norvegicus
Manually annotated by BRENDA team
Wiss, O.; Weber, F.
Die Reindarstellung der Kynureninase
Hoppe-Seyler's Z. Physiol. Chem.
304
232-240
1956
Sus scrofa
-
Manually annotated by BRENDA team
Moriguchi, M.; Soda, K.
Transamination reaction catalyzed by kynureninase and control of the enzyme activity
Biochemistry
12
1974-2980
1973
Pseudomonas marginalis
-
Manually annotated by BRENDA team
Moriguchi, M.; Yamamoto, T.; Soda, K.
Properties of crystalline Kynureninase from Pseudomonas marginalis
Biochemistry
12
2969-2974
1973
Pseudomonas marginalis
Manually annotated by BRENDA team
Shetty, A.S.; Gaertner, F.H.
Kynureninase-type enzymes of Penicillium roqueforti, Aspergillus niger, Rhizopus stolonifer, and Pseudomonas fluorescens: Further evidence for distinct kynureninase and hydroxykynureninase activities
J. Bacteriol.
122
235-244
1975
Aspergillus niger, Penicillium roqueforti, Pseudomonas fluorescens, Rhizopus stolonifer
Manually annotated by BRENDA team
Tanizawa, K.; Yamamoto, T.; Soda, K.
Crystalline inducible kynureninase of Neurospora crassa
FEBS Lett.
70
235-238
1976
Neurospora crassa
Manually annotated by BRENDA team
Tanizawa, K.; Soda, K.
The mechanism of kynurenine hydrolysis catalyzed by kynureninase
J. Biochem.
86
1199-1209
1979
Pseudomonas fluorescens
Manually annotated by BRENDA team
Tanizawa, K.; Soda, K.
Inducible and constitutive kynureninases. Control of the inducible enzyme activity by transamination and inhibition of the constitutive enzyme by 3-hydroxyanthranilate
J. Biochem.
86
499-508
1979
Neurospora crassa, Sus scrofa
Manually annotated by BRENDA team
Soda, K.; Tanizawa, K.
Kynureninases: Enzymological properties and regulation mechanism
Adv. Enzymol. Relat. Areas Mol. Biol.
49
1-40
1979
amphibia, Aspergillus niger, aves, Bos taurus, Canis lupus familiaris, Cavia porcellus, Chondrichthyes, Homo sapiens, Mus musculus, Neurospora crassa, Penicillium roqueforti, Pseudomonas fluorescens, Pseudomonas marginalis, Rattus norvegicus, Rhizopus stolonifer, Saccharomyces cerevisiae, Testudines, Xanthomonas arboricola pv. pruni
Manually annotated by BRENDA team
Tanizawa, K.; Soda, K.
Comparison of inducible and constitutive kynureninases of Neurospora crassa
J. Biochem.
85
1367-1375
1979
Neurospora crassa
Manually annotated by BRENDA team
Tanizawa, K.; Soda, K.
Purification and properties of pig liver kynureninase
J. Biochem.
85
901-906
1979
Sus scrofa
Manually annotated by BRENDA team
Takeuchi, F.; Otsuka, H.; Shibata, Y.
Purification and properties of kynureninase from rat liver
J. Biochem.
88
987-994
1980
Rattus norvegicus
Manually annotated by BRENDA team
Troost, T.; Hitchcock, M.J.M.; Katz, E.
Distinct kynureninase and hydroxykynureninase enzymes in an actinomycin-producing strain of Streptomyces parvulus
Biochim. Biophys. Acta
612
97-106
1980
Streptomyces parvulus
Manually annotated by BRENDA team
Bild, G.S.; Morris, J.C.
Detection of beta-carbanion formation during kynurenine hydrolysis catalyzed by Pseudomonas marginalis kynureninase
Arch. Biochem. Biophys.
235
41-47
1984
Pseudomonas marginalis
Manually annotated by BRENDA team
Kishore, G.M.
Mechanism-based inactivation of bacterial kynureninase by beta-substituted amino acids
J. Biol. Chem.
259
10669-10674
1984
Pseudomonas marginalis
Manually annotated by BRENDA team
Palcic, M.M.; Antoun, M.; Tanizawa, K.; Soda, K.; Floss, H.G.
Stereochemistry of the kynureninase reaction
J. Biol. Chem.
260
5248-5251
1985
Pseudomonas fluorescens
Manually annotated by BRENDA team
Shibata, Y.; Takeuchi, F.; Tsubouchi, R.; Haneda, M.; Ohta, T.; Nakatsuka, M.; Nisimoto, Y.; Tamai, T.; Nomura, S.; Fujimoto, H.; Sakata, M.; Maesaki, T.; Goda, K.
On kynureninase activity
Adv. Exp. Med. Biol.
294
523-526
1991
Rattus norvegicus
Manually annotated by BRENDA team
Okuno, E.; Kido, R.
Kynureninase and kynurenine 3-hydroxylase in mammalian tissues
Adv. Exp. Med. Biol.
294
167-176
1991
Homo sapiens, Rattus norvegicus, Suncus murinus
Manually annotated by BRENDA team
Phillips, R.S.; Dua, R.K.
Stereochemistry and mechanism of aldol reactions catalyzed by kynureninase
J. Am. Chem. Soc.
113
7385-7388
1991
Pseudomonas fluorescens
-
Manually annotated by BRENDA team
Carpenedo, R.; Chiarugi, A.; Russi, P.; Lombardi, G.; CarlÓ, V.; Pellicciari, R.; Mattoli, L.; Moroni, F.
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities
Neuroscience
61
237-244
1994
Rattus norvegicus
Manually annotated by BRENDA team
Moroni, F.; Carpenedo, R.; Chiarugi, A.
Kynurenine hydroxylase and kynureninase inhibitors as tools to study the role of kynurenine metabolites in the central nervous system
Adv. Exp. Med. Biol.
398
203-210
1996
Rattus norvegicus
Manually annotated by BRENDA team
Giordani, A.; Corti, L.; Cini, M.; Marconi, M.; Pillan, A.; Ferrario, R.; Schwarcz, R.; Guidetti, P.; Speciale, C.; Varasi, M.
Benzoylalanine analogues as inhibitors of rat brain kynureninase and kynurenine 3-hydroxylase
Adv. Exp. Med. Biol.
398
499-505
1996
Rattus norvegicus
Manually annotated by BRENDA team
Koushik, S.V.; Sundararaju, B.; McGraw, R.A.; Phillips, R.S.
Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens
Arch. Biochem. Biophys.
34
301-308
1997
Pseudomonas fluorescens
Manually annotated by BRENDA team
Fujigaki, S.; Saito, K.; Takemura, M.; Fujii, H.; Wada, H.; Noma, A.; Seishima, M.
Species differences in L-tryptophan-kynurenine pathway metabolism: quantification of anthranilic acid and its related enzymes
Arch. Biochem. Biophys.
358
329-335
1998
Oryctolagus cuniculus, Meriones unguiculatus
Manually annotated by BRENDA team
Phillips, R.S.; Sundararaju, B.; Koushik, S.V.
The catalytic mechanism of kynureninase from Pseudomonas fluorescens: Evidence for transient quinonoid and ketimine intermediates from rapid-scanning stopped-flow spectrophotometry
Biochemistry
37
8783-8789
1998
Pseudomonas fluorescens
Manually annotated by BRENDA team
Koushik, S.V.; Moore III, J.A.; Sundararaju, B.; Phillips, R.S.
The catalytic mechanism of kynureninase from Pseudomonas fluorescens: Insights from the effects of pH and isotopic substitution on steady-state and pre-steady-state kinetics
Biochemistry
37
1376-1382
1998
Pseudomonas fluorescens
Manually annotated by BRENDA team
Drysdale, M.J.; Reinhard, J.F.
S-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase
Bioorg. Med. Chem. Lett.
8
133-138
1998
Rattus norvegicus
Manually annotated by BRENDA team
Cyr, L.V.; Newton, M.G.; Phillips, R.S
Stereospecificity of Pseudomonas fluorescens kynureninase for diastereomers of beta-methylkynurenine
Bioorg. Med. Chem.
7
1497-1503
1999
Pseudomonas fluorescens
Manually annotated by BRENDA team
Allegri, G.; Bertazzo, A.; Biasiolo, M.; Costa, C.V.; Ragazzi, E.
Kynurenine pathway enzymes in different species of animals
Adv. Exp. Med. Biol.
527
455-463
2003
Cavia porcellus, Oryctolagus cuniculus, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Momany, C.; Levdikov, V.; Blagova, L.; Lima, S.; Phillips, R.S.
Three-dimensional structure of kynureninase from Pseudomonas fluorescens
Biochemistry
43
1193-1203
2004
Pseudomonas fluorescens (P83788), Pseudomonas fluorescens
Manually annotated by BRENDA team
Gawandi, V.B.; Liskey, D.; Lima, S.; Phillips, R.S.
Reaction of Pseudomonas fluorescens kynureninase with beta-benzoyl-L-alanine: Detection of a new reaction intermediate and a change in rate-determining step
Biochemistry
43
3230-3237
2004
Pseudomonas fluorescens
Manually annotated by BRENDA team
Fitzgerald, D.H.; Muirhead, K.M.; Botting, N.P.
A comparative study on the inhibition of human and bacterial kynureninase by novel bicyclic kynurenine analogues
Bioorg. Med. Chem.
9
983-989
2001
Homo sapiens, Pseudomonas fluorescens
Manually annotated by BRENDA team
Walsh, H.A.; O'Shea, K.C.; Botting, N.P.
Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase
BMC Biochem.
4
13
2003
Homo sapiens, Pseudomonas fluorescens, Rattus norvegicus
Manually annotated by BRENDA team
Walsh, H.A.; Botting, N.P.
Purification and biochemical characterization of some of the properties of recombinant human kynureninase
Eur. J. Biochem.
269
2069-2074
2002
Homo sapiens
Manually annotated by BRENDA team
Heiss, C.; Anderson, J.; Phillips, R.S.
Differential effects of bromination on substrates and inhibitors of kynureninase from Pseudomonas fluorescens
Org. Biomol. Chem.
1
288-295
2003
Pseudomonas fluorescens
Manually annotated by BRENDA team
Pellicciari, R.; Rizzo, R.C.; Costantino, G.; Marinozzi, M.; Amori, L.; Guidetti, P.; Wu, H.; Schwarcz, R.
Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor
ChemMedChem
1
528-531
2006
Rattus norvegicus
Manually annotated by BRENDA team
Allegri, G.; Ragazzi, E.; Costa, C.V.; Caparrotta, L.; Biasiolo, M.; Comai, S.; Bertazzo, A.
Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits
Clin. Chim. Acta
350
41-49
2004
Oryctolagus cuniculus
Manually annotated by BRENDA team
Comai, S.; Costa, C.V.; Ragazzi, E.; Bertazzo, A.; Allegri, G.
The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats
Clin. Chim. Acta
360
67-80
2005
Rattus norvegicus
Manually annotated by BRENDA team
Li, Y.; Wexler, M.; Richardson, D.J.; Bond, P.L.; Johnston, A.W.
Screening a wide host-range, waste-water metagenomic library in tryptophan auxotrophs of Rhizobium leguminosarum and of Escherichia coli reveals different classes of cloned trp genes
Environ. Microbiol.
7
1927-1936
2005
Escherichia coli, Rhizobium leguminosarum
Manually annotated by BRENDA team
Bouknight, R.R.; Sadoff, H.L.
Tryptophan catabolism in Bacillus megaterium
J. Bacteriol.
121
70-76
1975
Priestia megaterium
Manually annotated by BRENDA team
Lima, S.; Khristoforov, R.; Momany, C.; Phillips, R.S.
Crystal structure of Homo sapiens kynureninase
Biochemistry
46
2735-2744
2007
Homo sapiens (Q16719), Homo sapiens
Manually annotated by BRENDA team
Christensen, M.; Duno, M.; Lund, A.M.; Skovby, F.; Christensen, E.
Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase
J. Inherit. Metab. Dis.
30
248-255
2007
Homo sapiens
Manually annotated by BRENDA team
Meng, Y.; Katsuma, S.; Mita, K.; Shimada, T.
Abnormal red body coloration of the silkworm, Bombyx mori, is caused by a mutation in a novel kynureninase
Genes Cells
14
129-140
2009
Bombyx mori (B7XB98), Bombyx mori
Manually annotated by BRENDA team
Lima, S.; Kumar, S.; Gawandi, V.; Momany, C.; Phillips, R.S.
Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity
J. Med. Chem.
52
389-396
2009
Homo sapiens (Q16719), Homo sapiens
Manually annotated by BRENDA team
Kumar, S.; Gawandi, V.B.; Capito, N.; Phillips, R.S.
Substituent effects on the reaction of beta-benzoylalanines with Pseudomonas fluorescens kynureninase
Biochemistry
49
7913-7919
2010
Pseudomonas fluorescens
Manually annotated by BRENDA team
Feng, Y.; Bowden, B.; Kapoor, V.
Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata
Bioorg. Med. Chem. Lett.
22
3398-3401
2012
Rattus norvegicus
Manually annotated by BRENDA team
Maitrani, C.; Phillips, R.S.
Substituents effects on activity of kynureninase from Homo sapiens and Pseudomonas fluorescens
Bioorg. Med. Chem.
21
4670-4677
2013
Pseudomonas fluorescens (P83788), Pseudomonas fluorescens, Homo sapiens (Q16719), Homo sapiens
Manually annotated by BRENDA team
Phillips, R.S.; Scott, I.; Paulose, R.; Patel, A.; Barron, T.C.
The phosphate of pyridoxal-5'-phosphate is an acid/base catalyst in the mechanism of Pseudomonas fluorescens kynureninase
FEBS J.
281
1100-1109
2014
Pseudomonas fluorescens (P83788), Pseudomonas fluorescens
Manually annotated by BRENDA team
Phillips, R.; Crocker, M.; Lin, R.; Idowu, O.; McCannon, D.; Lima, S.
The roles of Ser-36, Asp-132 and Asp-201 in the reaction of Pseudomonas fluorescens kynureninase
Biochim. Biophys. Acta Proteins Proteom.
1867
722-731
2019
Pseudomonas fluorescens (P83788), Pseudomonas fluorescens
Manually annotated by BRENDA team
Liu, Y.; Feng, X.; Lai, J.; Yi, W.; Yang, J.; Du, T.; Long, X.; Zhang, Y.; Xiao, Y.
A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer
J. Cell. Mol. Med.
23
6700-6707
2019
Homo sapiens (Q16719), Homo sapiens
Manually annotated by BRENDA team