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3.6.1.17: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

This is an abbreviated version!
For detailed information about bis(5'-nucleosyl)-tetraphosphatase (asymmetrical), go to the full flat file.

Word Map on EC 3.6.1.17

Reaction

P1,P4-bis(5'-guanosyl) tetraphosphate
+
H2O
=
GTP
 +
GMP

Synonyms

(asymmetrical) diadenosine 5',5''‚-P1,P4-tetraphosphate hydrolase, (asymmetrical) dinucleoside tetraphosphatase, Ap4A hydrolase, Ap4A-hydrolase, AP4AASE, Apf, asym-di-GDPase, asymmetric Ap4A hydrolase, asymmetric diadenosine tetraphosphate hydrolase, asymmetrical Ap4A hydrolase, asymmetrical bis-(5'-nucleosidyl)-tetraphosphatase, asymmetrical diadenosine tetraphosphate hydrolase, AtNUDX25 protein, ATP-producing Ap4A hydrolase, bis(5'-adenosyl)-tetraphosphatase, bis(5'-guanosyl)-tetraphosphatase, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical), bis(5-guanosyl)tetraphosphatase, CT771, Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase, diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, diadenosine 5',5'-P1P4 tetraphosphate hydrolase, diadenosine 5,5-P1,P4-tetraphosphate hydrolase, diadenosine P1,P4-tetraphosphatase, Diadenosine tetraphosphatase, diadenosine tetraphosphate pyrophosphohydrolase, diguanosine tetraphosphatase, diguanosinetetraphosphatase (asymmetrical), diguanosinetetraphosphate guanosylhydrolase, dinucleoside tetraphosphatase, dinucleosidetetraphosphatase (asymmetrical), DIPP1, ENPP4, More, MXAN_1509, NDX-4, nudH, Nudix hydrolase, NUDT2, PFE1035c, PrpA

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

KI Value

KI Value on EC 3.6.1.17 - bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.031
1,2,3,4-tetra(adenosine-5'-O-phospho)erythritol
-
pH 7.6, 30°C
0.013 - 0.018
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
0.017 - 0.037
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
0.066
1,3-di(adenosine-5'-O-phospho)-2-phospho-glycerol
-
pH 7.6, 30°C
0.025 - 0.032
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
0.109
1,3-di(adenosine-5'-O-phospho)glycerol
-
pH 7.6, 30°C
0.0085 - 0.142
1,4-di(adenosine-5'-O-phospho)erythritol
0.00015 - 0.0015
1,4-di(adenosine-5'-O-phosphorothio)erythritol
0.00109
2-((8-hydroxy-4-(4-methyl-2-sulfoanilino)-9,10-dioxo-9,10-dihydro-1-anthracenyl)amino)-5-methylbenzenesulfonic acid
in 100 mM Tris-acetate, pH 7.7, 5 mM magnesium acetate, and 5% DMSO, at 25°C
0.005
2-[2-[(4-aminophenyl)amino]-6-phenylpyrimidin-4-yl]phenol
Ki about 0.005 mM, in 100 mM Tris-acetate, pH 7.7, 5 mM magnesium acetate, and 5% (v/v) DMSO, at 25°C
0.00289
5-methyl-2-[[4-(methylamino)-9,10-dioxo-9,10-dihydroanthracen-1-yl]amino]benzenesulfonate
in 100 mM Tris-acetate, pH 7.7, 5 mM magnesium acetate, and 5% (v/v) DMSO, at 25°C
0.0015 - 0.0025
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A
0.0021 - 0.0022
A-5'-p-beta,beta'-methyleneoxy-p-5'-A
0.00001
adenosine 5'-tetraphosphate
-
pH 7.8, 25°C
0.025 - 0.3
Ca2+
0.0037
di(adenosine-5'-O-phosphorothio)-di(adenosine-5'-phospho)pentaerythritol
-
pH 7.6, 30°C
0.003 - 1
F-
0.02
fluoride
-
-
0.01
guanosine 5'-tetraphosphate
-
-
0.00011
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,4,5,6-pentaphosphate
pH not specified in the publication, temperature not specified in the publication
0.00027
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
pH not specified in the publication, temperature not specified in the publication
0.000023
inositol 4-butyl-1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
pH not specified in the publication, temperature not specified in the publication