3.6.1.17: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

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For detailed information about bis(5'-nucleosyl)-tetraphosphatase (asymmetrical), go to the full flat file.

Reaction

Synonyms

(asymmetrical) diadenosine 5',5''�-P1,P4-tetraphosphate hydrolase, (asymmetrical) dinucleoside tetraphosphatase, Ap4A hydrolase, Ap4A-hydrolase, AP4AASE, Apf, asym-di-GDPase, asymmetric Ap4A hydrolase, asymmetric diadenosine tetraphosphate hydrolase, asymmetrical Ap4A hydrolase, asymmetrical bis-(5'-nucleosidyl)-tetraphosphatase, asymmetrical diadenosine tetraphosphate hydrolase, AtNUDX25 protein, ATP-producing Ap4A hydrolase, bis(5'-adenosyl)-tetraphosphatase, bis(5'-guanosyl)-tetraphosphatase, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical), bis(5-guanosyl)tetraphosphatase, CT771, Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase, diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, diadenosine 5',5'-P1P4 tetraphosphate hydrolase, diadenosine 5,5-P1,P4-tetraphosphate hydrolase, diadenosine P1,P4-tetraphosphatase, Diadenosine tetraphosphatase, diadenosine tetraphosphate pyrophosphohydrolase, diguanosine tetraphosphatase, diguanosinetetraphosphatase (asymmetrical), diguanosinetetraphosphate guanosylhydrolase, dinucleoside tetraphosphatase, dinucleosidetetraphosphatase (asymmetrical), DIPP1, ENPP4, More, MXAN_1509, NDX-4, nudH, Nudix hydrolase, NUDT2, PFE1035c, PrpA

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

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Results	in table
5	Activating Compound
2233	AA Sequence
1	CAS Registry Number
11	Cloned(Commentary)
5	Crystallization (Commentary)
51	Disease/ Diagnostics
6	General Information
1	IC50 Value
108	Inhibitors
16	kcat/KM [mM/s]
37	Ki Value [mM]
74	KM Value [mM]
9	Localization
52	Metals/Ions
23	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
52	Organism
3	Pathway
21	PDB ID
15	pH Optimum
6	pH Range
3	pH Stability
1	pI Value
28	Protein Variants
25	Purification (Commentary)
1	Reaction
3	Reaction Type
52	Reference
22	Source Tissue
21	Specific Activity [micromol/min/mg]
2	Storage Stability
124	Substrates and Products (Substrate)
3	Subunits
55	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
50	Turnover Number [1/s]

Disease

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Disease on EC 3.6.1.17 - bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Barrett Esophagus

ENPP4 overexpression is associated with no recovery from Barrett's esophagus.

33425094

Breast Neoplasms

A genome-wide association study for the number of teats in European rabbits (Oryctolagus cuniculus) identifies several candidate genes affecting this trait.

33428230

Breast Neoplasms

Direct Monitoring of Nucleotide Turnover in Human Cell Extracts and Cells by Fluorogenic ATP Analogs.

26274552

Breast Neoplasms

Nudix-type motif 2 in human breast carcinoma: A potent prognostic factor associated with cell proliferation.

20533549

Carcinoma, Ductal

Nudix-type motif 2 in human breast carcinoma: A potent prognostic factor associated with cell proliferation.

20533549

Carcinoma, Intraductal, Noninfiltrating

Nudix-type motif 2 in human breast carcinoma: A potent prognostic factor associated with cell proliferation.

20533549

Intellectual Disability

Novel NUDT2 variant causes intellectual disability and polyneuropathy.

33058507

Leukemia

Diadenosine tetraphosphatase from human leukemia cells. Purification to homogeneity and partial characterization.

6300076

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes.

27144453

Lymphatic Metastasis

Nudix-type motif 2 in human breast carcinoma: A potent prognostic factor associated with cell proliferation.

20533549

Malaria

Molecular characterization and mutational analysis of recombinant diadenosine 5',5?-P¹,P?-tetraphosphate hydrolase from Plasmodium falciparum.

22791172

Neoplasm Metastasis

Nudix-type motif 2 in human breast carcinoma: A potent prognostic factor associated with cell proliferation.

20533549

Neoplasm Metastasis

NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes.

27144453

Neoplasms

A mouse model of pulmonary metastasis from spontaneous osteosarcoma monitored in vivo by Luciferase imaging.

18350164

Neoplasms

NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes.

27144453

Polyneuropathies

Novel NUDT2 variant causes intellectual disability and polyneuropathy.

33058507

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