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3.6.1.17: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

This is an abbreviated version!
For detailed information about bis(5'-nucleosyl)-tetraphosphatase (asymmetrical), go to the full flat file.

Word Map on EC 3.6.1.17

Reaction

P1,P4-bis(5'-guanosyl) tetraphosphate
+
H2O
=
GTP
 +
GMP

Synonyms

(asymmetrical) diadenosine 5',5''‚-P1,P4-tetraphosphate hydrolase, (asymmetrical) dinucleoside tetraphosphatase, Ap4A hydrolase, Ap4A-hydrolase, AP4AASE, Apf, asym-di-GDPase, asymmetric Ap4A hydrolase, asymmetric diadenosine tetraphosphate hydrolase, asymmetrical Ap4A hydrolase, asymmetrical bis-(5'-nucleosidyl)-tetraphosphatase, asymmetrical diadenosine tetraphosphate hydrolase, AtNUDX25 protein, ATP-producing Ap4A hydrolase, bis(5'-adenosyl)-tetraphosphatase, bis(5'-guanosyl)-tetraphosphatase, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical), bis(5-guanosyl)tetraphosphatase, CT771, Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase, diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, diadenosine 5',5'-P1P4 tetraphosphate hydrolase, diadenosine 5,5-P1,P4-tetraphosphate hydrolase, diadenosine P1,P4-tetraphosphatase, Diadenosine tetraphosphatase, diadenosine tetraphosphate pyrophosphohydrolase, diguanosine tetraphosphatase, diguanosinetetraphosphatase (asymmetrical), diguanosinetetraphosphate guanosylhydrolase, dinucleoside tetraphosphatase, dinucleosidetetraphosphatase (asymmetrical), DIPP1, ENPP4, More, MXAN_1509, NDX-4, nudH, Nudix hydrolase, NUDT2, PFE1035c, PrpA

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

KM Value

KM Value on EC 3.6.1.17 - bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.3846
2-oxo-dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
0.0006 - 0.003
5',5''-diadenosine tetraphosphate
0.015
5',5'-diadenosine hexaphosphate
pH 7.5, 20 mM Mg2+
0.009 - 0.012
5',5'-diadenosine tetraphosphate
0.0986
8-oxo-dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
0.0041 - 10
Ap4A
0.098
Ap5A
-
pH 7.4, 37°C
0.04
Ap6A
-
pH 7.4, 37°C
0.1143
dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
0.182
dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
0.007
diadenosine 5',5''''-P1,P4-tetraphosphate
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
0.005 - 0.407
diadenosine 5',5''-P1,P4-tetraphosphate
0.002 - 0.0025
diadenosine 5',5'-P1,P4-tetraphosphate
0.0007 - 0.054
P1,P4-bis(5'-adenosyl) tetraphosphate
0.14
P1,P4-bis(5'-adenosyl)tetraphosphate
pH 8.0, 50°C, presence of 1 mM Mn2+
0.001 - 1.03
P1,P4-bis(5'-guanosyl) tetraphosphate
0.01 - 0.011
P1,P4-bis(5'-uridyl) tetraphosphate
0.016 - 0.018
P1,P4-bis(5'-xanthosyl) tetraphosphate
0.183
P1,P5-bis(5'-adenosyl) pentaphosphate
in 50 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, pH 7.6, at 25°C
0.19
P1,P5-bis(5'-adenosyl)pentaphosphate
pH 8.0, 50°C, presence of 1 mM Mn2+
0.089
P1,P6-bis(5'-adenosyl) hexaphosphate
in 50 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, pH 7.6, at 25°C
additional information
additional information
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