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3.6.1.17: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

This is an abbreviated version!
For detailed information about bis(5'-nucleosyl)-tetraphosphatase (asymmetrical), go to the full flat file.

Word Map on EC 3.6.1.17

Reaction

P1,P4-bis(5'-guanosyl) tetraphosphate
+
H2O
=
GTP
 +
GMP

Synonyms

(asymmetrical) diadenosine 5',5''‚-P1,P4-tetraphosphate hydrolase, (asymmetrical) dinucleoside tetraphosphatase, Ap4A hydrolase, Ap4A-hydrolase, AP4AASE, Apf, asym-di-GDPase, asymmetric Ap4A hydrolase, asymmetric diadenosine tetraphosphate hydrolase, asymmetrical Ap4A hydrolase, asymmetrical bis-(5'-nucleosidyl)-tetraphosphatase, asymmetrical diadenosine tetraphosphate hydrolase, AtNUDX25 protein, ATP-producing Ap4A hydrolase, bis(5'-adenosyl)-tetraphosphatase, bis(5'-guanosyl)-tetraphosphatase, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical), bis(5-guanosyl)tetraphosphatase, CT771, Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase, diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, diadenosine 5',5'-P1P4 tetraphosphate hydrolase, diadenosine 5,5-P1,P4-tetraphosphate hydrolase, diadenosine P1,P4-tetraphosphatase, Diadenosine tetraphosphatase, diadenosine tetraphosphate pyrophosphohydrolase, diguanosine tetraphosphatase, diguanosinetetraphosphatase (asymmetrical), diguanosinetetraphosphate guanosylhydrolase, dinucleoside tetraphosphatase, dinucleosidetetraphosphatase (asymmetrical), DIPP1, ENPP4, More, MXAN_1509, NDX-4, nudH, Nudix hydrolase, NUDT2, PFE1035c, PrpA

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

Inhibitors

Inhibitors on EC 3.6.1.17 - bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2,3,4-tetra(adenosine-5'-O-phospho)erythritol
-
-
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
1,3-di(adenosine-5'-O-phospho)-2-phospho-glycerol
-
-
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
1,3-di(adenosine-5'-O-phospho)glycerol
-
-
1,4-di(adenosine-5'-O-phospho)erythritol
1,4-di(adenosine-5'-O-phosphorothio)erythritol
1,4-dihydroxy-5,8-bis[(4-methylphenyl)amino]anthracene-9,10-dione
NSC86169
2-((8-hydroxy-4-(4-methyl-2-sulfoanilino)-9,10-dioxo-9,10-dihydro-1-anthracenyl)amino)-5-methylbenzenesulfonic acid
NSC51531, competitive inhibitor
2-[2-[(4-aminophenyl)amino]-6-phenylpyrimidin-4-yl]phenol
NSC232476
5-hydroxy-1,4-bis[(4-methylphenyl)amino]anthracene-9,10-dione
NSC300513
5-methyl-2-[[4-(methylamino)-9,10-dioxo-9,10-dihydroanthracen-1-yl]amino]benzenesulfonate
NSC401611
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A
A-5'-p-beta,beta'-methyleneoxy-p-5'-A
adenosine 5'-tetraphosphate
di(adenosine-5'-O-phosphorothio)-di(adenosine-5'-phospho)pentaerythritol
-
-
diadenosine 5',5'''-P1,P4-tetraphosphate
-
-
diadenosine triphosphate
-
competitive, also phosphonate analogues of the substance
fluoride
fructose-6-phosphate
-
slight inhibition
glycerol phosphate
20 mM, 46.1% residual activity
guanosine 5'-tetraphosphate
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,4,5,6-pentaphosphate
competitive
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
competitive
inositol 4-butyl-1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
competitive
iodoacetic acid
10 mM, 58.8% residual activity
Ionic strength
-
significant inhibition at high ionic strength
-
N-ethylmaleimide
1 mM, 73.8% residual activity
p-mercuribenzoate
-
-
perylene-3,4,9,10-tetracarboxylic acid
NSC89768
phosphate
-
inhibitory above 30 mM
trisodium phosphate
20 mM, 24.8% residual activity
uridine 5'-tetraphosphate
-
Ki in nanomolar range
additional information
NSC113427, NSC133815, and NSC305522, do not exhibit any enzyme inhibition at concentrations in excess of 0.1 mM
-