Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.1.17 extracted from

  • Branson, K.M.; Mertens, H.D.; Swarbrick, J.D.; Fletcher, J.I.; Kedzierski, L.; Gayler, K.R.; Gooley, P.R.; Smith, B.J.
    Discovery of inhibitors of lupin diadenosine 5,5-P1,P4-tetraphosphate hydrolase by virtual screening (2009), Biochemistry, 48, 7614-7620.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,4-dihydroxy-5,8-bis[(4-methylphenyl)amino]anthracene-9,10-dione NSC86169 Lupinus angustifolius
2-((8-hydroxy-4-(4-methyl-2-sulfoanilino)-9,10-dioxo-9,10-dihydro-1-anthracenyl)amino)-5-methylbenzenesulfonic acid NSC51531, competitive inhibitor Lupinus angustifolius
2-[2-[(4-aminophenyl)amino]-6-phenylpyrimidin-4-yl]phenol NSC232476 Lupinus angustifolius
5-hydroxy-1,4-bis[(4-methylphenyl)amino]anthracene-9,10-dione NSC300513 Lupinus angustifolius
5-methyl-2-[[4-(methylamino)-9,10-dioxo-9,10-dihydroanthracen-1-yl]amino]benzenesulfonate NSC401611 Lupinus angustifolius
additional information NSC113427, NSC133815, and NSC305522, do not exhibit any enzyme inhibition at concentrations in excess of 0.1 mM Lupinus angustifolius
perylene-3,4,9,10-tetracarboxylic acid NSC89768 Lupinus angustifolius

Organism

Organism UniProt Comment Textmining
Lupinus angustifolius O04841
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
Lupinus angustifolius ATP + AMP
-
?

Synonyms

Synonyms Comment Organism
Ap4A hydrolase
-
Lupinus angustifolius
diadenosine 5,5-P1,P4-tetraphosphate hydrolase
-
Lupinus angustifolius

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00109
-
2-((8-hydroxy-4-(4-methyl-2-sulfoanilino)-9,10-dioxo-9,10-dihydro-1-anthracenyl)amino)-5-methylbenzenesulfonic acid in 100 mM Tris-acetate, pH 7.7, 5 mM magnesium acetate, and 5% DMSO, at 25°C Lupinus angustifolius
0.00289
-
5-methyl-2-[[4-(methylamino)-9,10-dioxo-9,10-dihydroanthracen-1-yl]amino]benzenesulfonate in 100 mM Tris-acetate, pH 7.7, 5 mM magnesium acetate, and 5% (v/v) DMSO, at 25°C Lupinus angustifolius
0.005
-
2-[2-[(4-aminophenyl)amino]-6-phenylpyrimidin-4-yl]phenol Ki about 0.005 mM, in 100 mM Tris-acetate, pH 7.7, 5 mM magnesium acetate, and 5% (v/v) DMSO, at 25°C Lupinus angustifolius