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3.6.1.15: nucleoside-triphosphate phosphatase

This is an abbreviated version!
For detailed information about nucleoside-triphosphate phosphatase, go to the full flat file.

Word Map on EC 3.6.1.15

Reaction

a nucleoside triphosphate
+
H2O
=
a nucleoside diphosphate
 +
phosphate

Synonyms

AAA-type nucleoside triphosphatase phosphohydrolase, ankyrin repeat-rich membrane spanning protein, cell division control protein Cdc48, DEAH-box Prp22 protein, DEAH-box splicing factor Prp22, DExH-Box NTPase, DR_0079, germ-cell-specific leucine-rich repeat protein, GP086L protein, HCR-NTPase, HrpB, HrpB NTPase, human cancer-related nucleoside triphosphatase, KAP NTPase, Kidins220, kinase D interacting substance of 220 kDa, LDBPK_100150, LdNTPDase2, LINF_150005200, LiNTPDase1, LMXM_10_0170, LMXM_15_0030, LmxNTPDase1, LmxNTPDase2, M86L protein, MC100R, Mg2+-dependent NTPase, More, Msm0858, NALP14, non-specific nucleoside triphosphatase, nonstructural protein 13, NPH I, NS3, NS3 protein, NS3FL, nsp13, NTP1, NTP3, NTPase, NTPase 1, NTPase 2, NTPase-I, NTPase-II, NTPase/helicase, NTPDase, NTPDase 1, NTPDase1, NTPDase2, nucleic acid-independent nucleoside triphosphatase, nucleoside 5-triphosphatase, nucleoside triphosphatase, nucleoside triphosphatase (NTPase)/helicase, nucleoside triphosphate diphospho-hydrolase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate diphosphohydrolase 1, nucleoside triphosphate hydrolase, nucleoside triphosphate hydrolases I, nucleoside triphosphate hydrolases II, nucleoside triphosphate phosphohydrolase, nucleoside triphosphate phosphohydrolase I, nucleoside-5-triphosphate phosphohydrolase, nucleoside-triphosphatase 1, nucleoside-triphosphatase 2, nucleotide 5'-triphosphatase, P-loop NTPase, phosphatase, nucleoside tri-, PilB, PilT, PilU, polypeptide p41, protein NS3, PVA coat protein, PVA CP, PVx coat protein, PVX CP, Rad55B, RNA-dependent nucleoside triphosphatase, SHVp41, Sso0909, T4P motor protein, type IV pilus motor protein, YtkD

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.15 nucleoside-triphosphate phosphatase

KM Value

KM Value on EC 3.6.1.15 - nucleoside-triphosphate phosphatase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.8
2',3'-didehydro-thymidine triphosphate
-
pH 7.5, 25°C, NTP hydrolysis-dependent helicase activity
2.3
3'-azido-2',3'-dideoxythymidine triphosphate
-
pH 7.5, 25°C, NTP hydrolysis-dependent helicase activity
0.046 - 1.04
ADP
0.000028 - 2.5
ATP
0.082 - 0.5
CDP
0.006 - 3.8
CTP
0.145
dADP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.062 - 6.9
dATP
0.092
dCDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.023 - 4
dCTP
3.8
ddCTP
-
pH 7.5, 25°C, NTP hydrolysis-dependent helicase activity
0.9
ddTTP
-
pH 7.5, 25°C, NTP hydrolysis-dependent helicase activity
0.051
dGDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.083 - 0.144
dGTP
0.088
dITP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.0000000047
DNA duplex
-
-
-
0.04 - 2.4
dTTP
0.092
GDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.004 - 3.7
GTP
0.046
IDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.025 - 1.08
ITP
0.8
L-dATP
-
pH 7.5, 25°C, NTP hydrolysis-dependent helicase activity
9.9
L-dCTP
-
pH 7.5, 25°C, NTP hydrolysis-dependent helicase activity
28
L-dTTP
-
pH 7.5, 25°C, NTP hydrolysis-dependent helicase activity
0.0185
MgATP2-
-
concentration of MgATP2- higher than 0.006 mM
0.00032
RNA
-
wild-type transcriptase cofactor my2, 22°C, 6.5-7.0
0.105
TDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.007 - 0.138
TTP
0.137
UDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.005 - 9.4
UTP
additional information
additional information
-