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3.6.1.15: nucleoside-triphosphate phosphatase

This is an abbreviated version!
For detailed information about nucleoside-triphosphate phosphatase, go to the full flat file.

Word Map on EC 3.6.1.15

Reaction

a nucleoside triphosphate
+
H2O
=
a nucleoside diphosphate
 +
phosphate

Synonyms

AAA-type nucleoside triphosphatase phosphohydrolase, ankyrin repeat-rich membrane spanning protein, cell division control protein Cdc48, DEAH-box Prp22 protein, DEAH-box splicing factor Prp22, DExH-Box NTPase, DR_0079, germ-cell-specific leucine-rich repeat protein, GP086L protein, HCR-NTPase, HrpB, HrpB NTPase, human cancer-related nucleoside triphosphatase, KAP NTPase, Kidins220, kinase D interacting substance of 220 kDa, LDBPK_100150, LdNTPDase2, LINF_150005200, LiNTPDase1, LMXM_10_0170, LMXM_15_0030, LmxNTPDase1, LmxNTPDase2, M86L protein, MC100R, Mg2+-dependent NTPase, More, Msm0858, NALP14, non-specific nucleoside triphosphatase, nonstructural protein 13, NPH I, NS3, NS3 protein, NS3FL, nsp13, NTP1, NTP3, NTPase, NTPase 1, NTPase 2, NTPase-I, NTPase-II, NTPase/helicase, NTPDase, NTPDase 1, NTPDase1, NTPDase2, nucleic acid-independent nucleoside triphosphatase, nucleoside 5-triphosphatase, nucleoside triphosphatase, nucleoside triphosphatase (NTPase)/helicase, nucleoside triphosphate diphospho-hydrolase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate diphosphohydrolase 1, nucleoside triphosphate hydrolase, nucleoside triphosphate hydrolases I, nucleoside triphosphate hydrolases II, nucleoside triphosphate phosphohydrolase, nucleoside triphosphate phosphohydrolase I, nucleoside-5-triphosphate phosphohydrolase, nucleoside-triphosphatase 1, nucleoside-triphosphatase 2, nucleotide 5'-triphosphatase, P-loop NTPase, phosphatase, nucleoside tri-, PilB, PilT, PilU, polypeptide p41, protein NS3, PVA coat protein, PVA CP, PVx coat protein, PVX CP, Rad55B, RNA-dependent nucleoside triphosphatase, SHVp41, Sso0909, T4P motor protein, type IV pilus motor protein, YtkD

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.15 nucleoside-triphosphate phosphatase

Inhibitors

Inhibitors on EC 3.6.1.15 - nucleoside-triphosphate phosphatase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-beta-D-ribofuranosyl-1H-benzotriazole
1-beta-D-ribofuranosyl-4,5,6,7-tetrabromo-1H-benzotriazole
1-beta-D-ribofuranosyl-4,5,6,7-tetramethyl-1H-benzotriazole
1-beta-D-ribofuranosyl-4,7-dibromo-1H-benzotriazole
1-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole
1-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole
1-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole
1-methyl-4,5,6,7-tetrabromo-1H-benzotriazole
1-propyl-4,5,6,7-tetrabromo-1H-benzotriazole
2',3'-didehydro-thymidine triphosphate
-
competitive to ATP
2',3'-dideoxy-5-fluorocytidine triphosphate
-
competitive to ATP
2-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole
2-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole
2-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole
2-methyl-4,5,6,7-tetrabromo-1H-benzotriazole
2-propyl-4,5,6,7-tetrabromo-1H-benzotriazole
3'-azido-2',3'-dideoxythymidine triphosphate
-
competitive to ATP
4,5,6,7-tetrabromo-1H-benzotriazole
4,5-dihydro-8H-6-(N-decyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione
-
IC50: 30-100 mg/l
4,5-dihydro-8H-6-(N-dodecyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione
-
IC50: 1-3 mg/l
4,5-dihydro-8H-6-(N-dodecylamino)-1-(2'-deoxy-alpha-D-erythropentofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione
-
IC50: 3-10 mg/l
4,5-dihydro-8H-6-(N-dodecylamino)-1-(2'-deoxy-beta-D-erythropentofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione
-
IC50: 3-10 mg/l
4,5-dihydro-8H-6-(N-hexadecyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione
-
IC50: 250 mg/l
4,5-dihydro-8H-6-(N-octadecyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione
-
IC50: 5.0 mg/l
4,5-dihydro-8H-6-(N-tetradecyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione
-
IC50: 3-10 mg/l
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzotriazole
5-fluoro-2-selenocytosine
-
IC50: 0.075 mM for NTPase reaction, no influence to helicase activity up to a concentration of 0.5 mM
beta,gamma-methylene-ATP
-
-
Ca2+
-
at high concentrations
CaCl2
in presence of Mn2+, 10 mM MgCl2 inhibits 20%
choline
-
at concentration above 20 mM
Cs+
-
at concentration above 20 mM
dATP
-
competitive to ATP
dCTP
-
competitive to ATP
ddCTP
-
competitive to ATP
ddTTP
-
competitive to ATP
dGTP
-
competitive to ATP
dTTP
-
competitive to ATP
formononetin 7-O-glucoside
-
-
guanidine hydrochloride
-
-
HOCl
-
inhibits the muclear NTPase, taurine acts as antagonist and reduces the hypochlorous acid toxicity
iodoacetamide
-
-
L-dATP
-
competitive to ATP
L-dCTP
-
competitive to ATP
L-ddCTP
-
competitive to ATP
L-dTTP
-
competitive to ATP
Mg2+
-
above 10 mM
MgCl2
in presence of Mn2+, 10 mM MgCl2 inhibits 10%
N-ethylmaleimide
-
-
NaCl
100 mM, inhibits ATP hydrolysis by 30%
O6-benzyl-N7-chloroethylguanine
-
weak inhibition of NTPase activity, enhances helicase activity
O6-benzylguanine
-
weak inhibitor of ATPase and helicase activity
oligo(dA)25
-
above 0.5 mM, inhibits unwinding reaction
-
oligomycin
-
-
p-hydroxymercuribenzoate
-
-
Phenylarsine oxide
-
-
polyA
inhibits to a lesser extent than polyC and polyU
polyC
1 mg/l, 70% inhibition
polyG
inhibits to a lesser extent than polyC and polyU
polyU
1 mg/l, 70% inhibition
Proflavine
-
-
propionate
-
39% relative activity at a concentration of 0.5 mM, 63% relative activity at a concentration of 0.05 mM
Rb+
-
at concentration above 20 mM
ribavirin-TP
-
at ATP concentration equal to Km, IC50 of NTPase reaction is 0.4 mM, classical competitive inhibitor with regard to ATP. At ATP and DNA duplex concentrations corresponding to their KM-values an IC50 of 0.12 mM is measured. Inhibition reaches a maximum of 30% of the control at 0.45 mM and is not competitive with regard to ATP
RNA
homopolymeric RNA inhibits under otherwise optimal conditions
Sodium fluoride
-
-
additional information
-