Literature summary for 3.6.1.15 extracted from

Zhang, N.; Chen, H.M.; Koch, V.; Schmitz, H.; Minczuk, M.; Stepien, P.; Fattom, A.I.; Naso, R.B.; Kalicharran, K.; Borowski, P.; Hosmane, R.S.
Potent inhibition of NTPase/helicase of the West Nile Virus by ring-expanded ("fat") nucleoside analogues (2003), J. Med. Chem., 46, 4776-4789.

Search for more literature for 3.6.1.15

Activating Compound

Activating Compound	Comment	Organism	Structure
4,5-dihydro-8H-6-(N-phenyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione	activates	West Nile virus

Inhibitors

Inhibitors	Comment	Organism	Structure
4,5-dihydro-8H-6-(N-decyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione	IC50: 30-100 mg/l	West Nile virus
4,5-dihydro-8H-6-(N-dodecyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione	IC50: 1-3 mg/l	West Nile virus
4,5-dihydro-8H-6-(N-dodecylamino)-1-(2'-deoxy-alpha-D-erythropentofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione	IC50: 3-10 mg/l	West Nile virus
4,5-dihydro-8H-6-(N-dodecylamino)-1-(2'-deoxy-beta-D-erythropentofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione	IC50: 3-10 mg/l	West Nile virus
4,5-dihydro-8H-6-(N-hexadecyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione	IC50: 250 mg/l	West Nile virus
4,5-dihydro-8H-6-(N-octadecyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione	IC50: 5.0 mg/l	West Nile virus
4,5-dihydro-8H-6-(N-tetradecyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione	IC50: 3-10 mg/l	West Nile virus

Organism

Organism	UniProt	Comment	Textmining
West Nile virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	-	West Nile virus	ADP + phosphate	-	?
additional information	helicase activity with RNA duplex	West Nile virus	?	-	?

Synonyms

Synonyms	Comment	Organism
NTPase/helicase	-	West Nile virus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)