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Literature summary for 3.6.1.15 extracted from

  • Bretner, M.; Baier, A.; Kopanska, K.; Najda, A.; Schoof, A.; Reinholz, M.; Lipniacki, A.; Piasek, A.; Kulikowski, T.; Borowski, P.
    Synthesis and biological activity of 1H-benzotriazole and 1H-benzimidazole analogues - inhibitors of the NTPase/helicase of HCV and of some related Flaviviridae (2005), Antiviral Chem. Chemother., 16, 315-326.
    View publication on PubMed
Search for more literature for 3.6.1.15

Cloned(Commentary)

Cloned (Comment) Organism
enzyme expression in Escherichia coli Dengue virus
enzyme expression in Escherichia coli Japanese encephalitis virus
expression of NS3 in Escherichia coli Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
1-beta-D-ribofuranosyl-1H-benzotriazole
-
 Dengue virus
1-beta-D-ribofuranosyl-1H-benzotriazole
-
 Hepacivirus C
1-beta-D-ribofuranosyl-1H-benzotriazole
-
 Japanese encephalitis virus
1-beta-D-ribofuranosyl-1H-benzotriazole
-
 West Nile virus
1-beta-D-ribofuranosyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
1-beta-D-ribofuranosyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
1-beta-D-ribofuranosyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
1-beta-D-ribofuranosyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
1-beta-D-ribofuranosyl-4,5,6,7-tetramethyl-1H-benzotriazole
-
 Dengue virus
1-beta-D-ribofuranosyl-4,5,6,7-tetramethyl-1H-benzotriazole
-
 Hepacivirus C
1-beta-D-ribofuranosyl-4,5,6,7-tetramethyl-1H-benzotriazole
-
 Japanese encephalitis virus
1-beta-D-ribofuranosyl-4,5,6,7-tetramethyl-1H-benzotriazole
-
 West Nile virus
1-beta-D-ribofuranosyl-4,7-dibromo-1H-benzotriazole
-
 Dengue virus
1-beta-D-ribofuranosyl-4,7-dibromo-1H-benzotriazole
-
 Hepacivirus C
1-beta-D-ribofuranosyl-4,7-dibromo-1H-benzotriazole
-
 Japanese encephalitis virus
1-beta-D-ribofuranosyl-4,7-dibromo-1H-benzotriazole
-
 West Nile virus
1-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
1-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
1-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
1-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
1-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
1-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
1-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
1-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
1-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
1-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
1-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
1-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
1-methyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
1-methyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
1-methyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
1-methyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
1-propyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
1-propyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
1-propyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
1-propyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
2-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
2-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
2-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
2-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
2-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
2-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
2-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
2-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
2-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
2-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
2-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
2-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
2-methyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
2-methyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
2-methyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
2-methyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
2-propyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
2-propyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
2-propyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
2-propyl-4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
4,5,6,7-tetrabromo-1H-benzotriazole
-
 Dengue virus
4,5,6,7-tetrabromo-1H-benzotriazole
-
 Hepacivirus C
4,5,6,7-tetrabromo-1H-benzotriazole
-
 Japanese encephalitis virus
4,5,6,7-tetrabromo-1H-benzotriazole
-
 West Nile virus
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzotriazole
-
 Dengue virus
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzotriazole
-
 Hepacivirus C
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzotriazole
-
 Japanese encephalitis virus
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzotriazole
-
 West Nile virus
additional information inhibitor cytotoxicity study, overview Dengue virus
additional information inhibitor cytotoxicity study, overview Hepacivirus C
additional information inhibitor cytotoxicity study, overview Japanese encephalitis virus
additional information inhibitor cytotoxicity study, overview West Nile virus

Metals/Ions

Metals/Ions Comment Organism Structure
NaCl stimulates Dengue virus
NaCl stimulates Hepacivirus C
NaCl stimulates West Nile virus
NaCl stimulates Japanese encephalitis virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Dengue virus NTPase activity ADP + phosphate
-
 ?
ATP + H2O Hepacivirus C NTPase activity ADP + phosphate
-
 ?
ATP + H2O West Nile virus NTPase activity ADP + phosphate
-
 ?
ATP + H2O Japanese encephalitis virus NTPase activity ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Dengue virus
-
 i.e. DENV
-
Hepacivirus C
-
 i.e. HCV
-
Japanese encephalitis virus
-
 i.e. JEV
-
West Nile virus
-
 i.e. WNV
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from virus Vero E6 cell culture medium by affinity chromatography, ultrafiltration, and gel filtration West Nile virus
recombinant enzyme from Escherichia coli Dengue virus
recombinant enzyme from Escherichia coli Japanese encephalitis virus
recombinant NS3 from Escherichia coli Hepacivirus C

Source Tissue

Source Tissue Comment Organism Textmining
additional information virus from Vero E6 cell culture, excreted to the medium West Nile virus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O NTPase activity Dengue virus ADP + phosphate
-
 ?
ATP + H2O NTPase activity Hepacivirus C ADP + phosphate
-
 ?
ATP + H2O NTPase activity West Nile virus ADP + phosphate
-
 ?
ATP + H2O NTPase activity Japanese encephalitis virus ADP + phosphate
-
 ?
additional information multifunctional enzyme showing nucleoside triphosphatase NTPase/RNA helicase and a 5'-RNA triphosphatase RTPase activities Dengue virus ?
-
 ?
additional information multifunctional enzyme showing nucleoside triphosphatase NTPase/RNA helicase and a 5'-RNA triphosphatase RTPase activities Hepacivirus C ?
-
 ?
additional information multifunctional enzyme showing nucleoside triphosphatase NTPase/RNA helicase and a 5'-RNA triphosphatase RTPase activities West Nile virus ?
-
 ?
additional information multifunctional enzyme showing nucleoside triphosphatase NTPase/RNA helicase and a 5'-RNA triphosphatase RTPase activities Japanese encephalitis virus ?
-
 ?

Synonyms

Synonyms Comment Organism
NS3
-
 Hepacivirus C
NTPase/helicase
-
 Dengue virus
NTPase/helicase
-
 Hepacivirus C
NTPase/helicase
-
 West Nile virus
NTPase/helicase
-
 Japanese encephalitis virus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Dengue virus
7.5
-
 assay at Hepacivirus C
7.5
-
 assay at West Nile virus
7.5
-
 assay at Japanese encephalitis virus