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3.6.1.15: nucleoside-triphosphate phosphatase

This is an abbreviated version!
For detailed information about nucleoside-triphosphate phosphatase, go to the full flat file.

Word Map on EC 3.6.1.15

Reaction

a nucleoside triphosphate
+
H2O
=
a nucleoside diphosphate
 +
phosphate

Synonyms

AAA-type nucleoside triphosphatase phosphohydrolase, ankyrin repeat-rich membrane spanning protein, cell division control protein Cdc48, DEAH-box Prp22 protein, DEAH-box splicing factor Prp22, DExH-Box NTPase, DR_0079, germ-cell-specific leucine-rich repeat protein, GP086L protein, HCR-NTPase, HrpB, HrpB NTPase, human cancer-related nucleoside triphosphatase, KAP NTPase, Kidins220, kinase D interacting substance of 220 kDa, LDBPK_100150, LdNTPDase2, LINF_150005200, LiNTPDase1, LMXM_10_0170, LMXM_15_0030, LmxNTPDase1, LmxNTPDase2, M86L protein, MC100R, Mg2+-dependent NTPase, More, Msm0858, NALP14, non-specific nucleoside triphosphatase, nonstructural protein 13, NPH I, NS3, NS3 protein, NS3FL, nsp13, NTP1, NTP3, NTPase, NTPase 1, NTPase 2, NTPase-I, NTPase-II, NTPase/helicase, NTPDase, NTPDase 1, NTPDase1, NTPDase2, nucleic acid-independent nucleoside triphosphatase, nucleoside 5-triphosphatase, nucleoside triphosphatase, nucleoside triphosphatase (NTPase)/helicase, nucleoside triphosphate diphospho-hydrolase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate diphosphohydrolase 1, nucleoside triphosphate hydrolase, nucleoside triphosphate hydrolases I, nucleoside triphosphate hydrolases II, nucleoside triphosphate phosphohydrolase, nucleoside triphosphate phosphohydrolase I, nucleoside-5-triphosphate phosphohydrolase, nucleoside-triphosphatase 1, nucleoside-triphosphatase 2, nucleotide 5'-triphosphatase, P-loop NTPase, phosphatase, nucleoside tri-, PilB, PilT, PilU, polypeptide p41, protein NS3, PVA coat protein, PVA CP, PVx coat protein, PVX CP, Rad55B, RNA-dependent nucleoside triphosphatase, SHVp41, Sso0909, T4P motor protein, type IV pilus motor protein, YtkD

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.15 nucleoside-triphosphate phosphatase

Activating Compound

Activating Compound on EC 3.6.1.15 - nucleoside-triphosphate phosphatase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxoglutarate
-
stimulating in physiological concentrations, 148% relative activity at a concentration of 0.5 mM, 128% relative activity at a concentration of 0.05 mM
4,5-dihydro-8H-6-(N-phenyl)amino-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8-dione
-
activates
acetyl-CoA
-
stimulating in physiological concentrations, 148% relative activity at a concentration of 0.5 mM, 127% relative activity at a concentration of 0.05 mM
choline
-
activates at concentration below 20 mM
D-fructose 1,6-bisphosphate
-
stimulating in physiological concentrations, 155% relative activity at a concentration of 0.5 mM, 126% relative activity at a concentration of 0.05 mM
D-glucose
increases Vmax, especially in presence of cations
O6-benzyl-N7-chloroethylguanine
-
weak inhibition of NTPase activity, enhances helicase activity up to 850% of control
O6-benzyl-N9-chloroethylguanine
-
stimulates NTPase activity with a maximum effect of 350% of control at 0.65 mM, enhances helicase activity up to 220% of control
periodate-treated dATP
is added to stimulate NPH I function
-
Poly(A)
-
stimulates the ATP hydrolysis dependent on the chain length, highest activation by poly(A)40 comapred to shorter molecules
poly(dA)
-
1.7-3.3 mM, activation of ATPase activity to 170-180% of control
Poly(U)
-
the activation by poly(U) is inhibited by K+
Polynucleotide
-
denatured DNA and RNA, synthetic RNA and DNA hybrids
RNA
-
stimulates the ATP hydrolysis dependent on the chain length
ssRNA
dependent on
-
sucrose
increases Vmax, especially in presence of cations
taurine
-
activates the enzyme, and acts as antagonist and reduces the hypochlorous acid toxicity
additional information
-