3.6.1.12: dCTP diphosphatase

This is an abbreviated version!
For detailed information about dCTP diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.12

3.6.1.12

nudix

mutt

ap4a

diadenosine

decapping

dihydrate

triphosphorylated

dinucleoside

5',5'-p1,p4-tetraphosphate

8-oxo-dgtpase

exoribonuclease

8-oxo-2'-deoxyguanosine

5'-end-dependent

8-oxo-dgmp

drug development

medicine

Reaction

dCTP

+

H2O

=

dCMP

+

diphosphate

Synonyms

all-alpha dCTP pyrophosphatase 1, all-alpha NTP pyrophosphatase, all-alpha nucleoside triphosphate pyrophosphatase, dCTP pyrophosphatase, dCTP pyrophosphatase 1, dCTPase, dCTPase 1, dCTPase-dUTPase, DCTPP1, deoxy-CTPase, deoxycytidine triphosphatase, deoxycytidine-triphosphatase, NTP pyrophosphatase, NTP pyrophosphohydrolase, phosphatase, deoxycytidine, tri-, pyrophosphohydrolase, RS21-C6, XTP3-TPA, XTP3-transactivated protein A, XTP3TPA

ECTree

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.12 dCTP diphosphatase

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Results	in table
2063	AA Sequence
4	Application
1	CAS Registry Number
8	Cloned(Commentary)
1	Crystallization (Commentary)
106	Disease/ Diagnostics
3	Expression
16	General Information
95	IC50 Value
175	Inhibitors
29	kcat/KM [mM/s]
5	Ki Value [mM]
32	KM Value [mM]
5	Localization
5	Metals/Ions
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
21	Organism
5	Pathway
16	PDB ID
2	pH Optimum
2	pH Range
4	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
20	Reference
13	Source Tissue
1	Specific Activity [micromol/min/mg]
50	Substrates and Products (Substrate)
4	Subunits
39	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
29	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.6.1.12 - dCTP diphosphatase

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0.000046

(2-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid

Homo sapiens

pH 8.0, 22°C

0.0011

(2-chlorophenyl)[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone

Homo sapiens

pH and temperature not specified in the publication

0.000082

(3-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid

Homo sapiens

pH 8.0, 22°C

0.000206

(4-((4-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid

Homo sapiens

pH 8.0, 22°C

0.000027

(4-((5,6-dichloro-2-cyclopropyl-4-nitro-1H-benzo[d]imidazol-1-yl)methyl)phenyl)boronic acid

Homo sapiens

pH 8.0, 22°C

0.000248

(4-((5,6-dichloro-2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-phenyl)boronic acid

Homo sapiens

pH 8.0, 22°C

0.000046

(4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid

Homo sapiens

pH 8.0, 22°C

0.000529

(4-((5,6-difluoro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid

Homo sapiens

pH 8.0, 22°C

0.0034

1,3-dimethyl-8-[4-(2-thienylcarbonyl)-1-piperazinyl]-3,7-dihydro-1H-purine-2,6-dione

Homo sapiens

pH and temperature not specified in the publication

0.000075

1-(4-(1H-pyrazol-1-yl)benzyl)-5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.000331

1-(4-(1H-pyrrol-1-yl)benzyl)-5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.1

1-(4-methoxybenzyl)-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.022

1-(4-methoxybenzyl)-2,5,6-trimethyl-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.000057

1-(4-methoxybenzyl)-2,5,6-trimethyl-4-nitro-1H-benzo[d]-imidazole

Homo sapiens

pH 8.0, 22°C

0.1

1-(4-methoxybenzyl)-2-methyl-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.00145

1-(4-methoxybenzyl)-2-methyl-4-nitro-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.1

1-(4-methoxybenzyl)-5,6-dimethyl-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.00084

1-(7-methyl-2-[[(2-methylphenyl)methyl]sulfanyl][1,2,4]triazolo[1,5-a]pyrimidin-6-yl)ethan-1-one

Homo sapiens

pH and temperature not specified in the publication

0.000074

1-(benzenesulfonyl)-5,6-dichloro-2-methyl-4-nitro-1H-benzimidazole

Homo sapiens

pH 8.0, 22°C

0.000049

1-benzyl-5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.00089

1-[[4-(5-methyl-4-oxo-3-phenyl-4,5-dihydro[1,2]oxazolo[4,5-c]pyridin-6-yl)phenyl]methyl]pyrrolidine-2,5-dione

Homo sapiens

pH and temperature not specified in the publication

0.0014

2,3-dimethyl-5-oxo-N-(1-phenylethyl)-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide

Homo sapiens

pH and temperature not specified in the publication

0.00036

2-(2-chlorophenyl)-5-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazole

Homo sapiens

pH and temperature not specified in the publication

0.00086

2-(2-methylphenyl)-5-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazole

Homo sapiens

pH and temperature not specified in the publication

0.000047

2-(4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl)methyl)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

Homo sapiens

pH 8.0, 22°C

0.0013

2-(4-methylphenyl)-5-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazole

Homo sapiens

pH and temperature not specified in the publication

0.0026

2-(4-phenylpiperazin-1-yl)-4-(trifluoromethyl)quinazoline

Homo sapiens

pH and temperature not specified in the publication

0.0011

2-methyl-4-(3-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)quinoline

Homo sapiens

pH and temperature not specified in the publication, recombinant enzyme

0.00058

2-methyl-N-(4-oxo-6,7,8,9-tetrahydro-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl)benzamide

Homo sapiens

pH and temperature not specified in the publication

0.001

2-[(2E)-2-[(1H-indol-3-yl)methylidene]hydrazinyl]-3,7-dimethylquinoline

Homo sapiens

pH and temperature not specified in the publication

0.00024

2-[(2E)-2-[(1H-indol-3-yl)methylidene]hydrazinyl]-4-methylquinoline

Homo sapiens

pH and temperature not specified in the publication

0.00078

2-[1-(4-fluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-5-phenyl-1,3,4-oxadiazole

Homo sapiens

pH and temperature not specified in the publication

0.0148

2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl 2-(4-methoxyphenyl)-3-methyl-4-oxo-1,2,3,3a,4,9b-hexahydro[1]benzopyrano[3,4-b]pyrrole-1-carboxylate

Homo sapiens

pH and temperature not specified in the publication, recombinant enzyme

0.0015

2-[4-(3-methoxyphenyl)piperazin-1-yl]-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one

Homo sapiens

pH and temperature not specified in the publication

0.0015

2-[4-(3-methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0022

2-[4-(3-methoxyphenyl)piperazin-1-yl]-6-methyl-5-propylpyrimidin-4(3H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0011

2-[4-[(2H-1,3-benzodioxol-5-yl)methyl]piperazin-1-yl]-6-tert-butylpyrimidin-4(3H)-one

Homo sapiens

pH and temperature not specified in the publication

0.00099

2-[5-cyclopropyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl]-5-phenyl-1,3,4-oxadiazole

Homo sapiens

pH and temperature not specified in the publication

0.0021

2-[5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl]-5-(2-methylphenyl)-1,3,4-oxadiazole

Homo sapiens

pH and temperature not specified in the publication

0.1

3,5-dimethyl-6-phenyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

above, pH and temperature not specified in the publication

0.0016

3-(2-chlorophenyl)-5-methyl-6-[4-[(pyrrolidin-1-yl)methyl]phenyl][1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.00028

3-(2-chlorophenyl)-5-methyl-6-[4-[(pyrrolidin-1-yl)methyl]phenyl][1,2]oxazolo[5,4-d]pyrimidin-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.000021

4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl)methyl)phenol

Homo sapiens

pH 8.0, 22°C

0.00024

4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)-2-methylthiazole

Homo sapiens

pH 8.0, 22°C

0.000133

4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)benzaldehyde

Homo sapiens

pH 8.0, 22°C

0.000073

4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)benzoic acid

Homo sapiens

pH 8.0, 22°C

0.000165

4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)benzonitrile

Homo sapiens

pH 8.0, 22°C

0.000034

4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl acetate

Homo sapiens

pH 8.0, 22°C

0.0025

4-chloro-5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-2-phenylpyridazin-3(2H)-one

Homo sapiens

pH and temperature not specified in the publication

0.00066

4-chloro-5-[4-(2-methoxybenzoyl)piperazin-1-yl]-2-phenylpyridazin-3(2H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0012

4-chloro-5-[4-(4-ethoxybenzoyl)piperazin-1-yl]-2-phenylpyridazin-3(2H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0032

4-chloro-5-[4-(methanesulfonyl)piperazin-1-yl]-2-phenylpyridazin-3(2H)-one

Homo sapiens

pH and temperature not specified in the publication

0.00037

4-methyl-2-[(2E)-2-[(1-methyl-1H-indol-3-yl)methylidene]hydrazinyl]quinoline

Homo sapiens

pH and temperature not specified in the publication

0.000185

5,6-dichloro-1-((6-chloropyridin-3-yl)methyl)-2-methyl-4-nitro-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.000109

5,6-dichloro-1-(2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl)-2-methyl-4-nitro-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.012

5,6-dichloro-1-(4-methoxybenzyl)-2-methyl-1H-benzo[d]-imidazole

Homo sapiens

pH 8.0, 22°C

0.000041

5,6-dichloro-1-(4-methoxybenzyl)-2-methyl-4-nitro-1H-benzo-[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.000019

5,6-dichloro-2-methyl-1-(4-methylbenzyl)-4-nitro-1H-benzo[d]-imidazole

Homo sapiens

pH 8.0, 22°C

0.000205

5,6-dichloro-2-methyl-4-nitro-1-(phenylsulfonyl)-1H-benzo[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.000085

5,6-dichloro-2-methyl-4-nitro-1-phenyl-1H-benzo-[d]imidazole

Homo sapiens

pH 8.0, 22°C

0.0018

5-benzyl-3-phenyl-6-[4-[(pyrrolidin-1-yl)methyl]phenyl][1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0015

5-ethenyl-2-[4-(3-methoxyphenyl)piperazin-1-yl]-6-methylpyrimidin-4(3H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0014

5-ethyl-2-[4-(3-methoxyphenyl)piperazin-1-yl]-6-methylpyrimidin-4(3H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0011

5-ethyl-2-[4-(4-methoxyphenyl)piperazin-1-yl]-6-methylpyrimidin-4(3H)-one

Homo sapiens

pH and temperature not specified in the publication

0.00094

5-ethyl-3-[[2-(1-piperidinyl)ethyl]thio]-5H-[1,2,4]triazino[5,6-b]indole

Homo sapiens

pH and temperature not specified in the publication

0.00055

5-ethyl-8-methoxy-3-[[2-(4-morpholinyl)ethyl]thio]-5H-[1,2,4]triazino[5,6-b]indole

Homo sapiens

pH and temperature not specified in the publication

0.1

5-methyl-2-phenyl-6-[4-[(pyrrolidin-1-yl)methyl]phenyl]furo[3,2-c]pyridin-4(5H)-one

Homo sapiens

above, pH and temperature not specified in the publication

0.1

5-methyl-3,6-diphenyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

above, pH and temperature not specified in the publication

0.0084

5-methyl-3-(pyridin-2-yl)-6-[4-[(pyrrolidin-1-yl)methyl]phenyl][1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.00085

5-methyl-3-(pyridin-3-yl)-6-[4-[(pyrrolidin-1-yl)methyl]phenyl][1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0015

5-methyl-3-phenyl-6-[4-[(pyrrolidin-1-yl)methyl]phenyl][1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0016

5-methyl-3-phenyl-6-[4-[(pyrrolidin-1-yl)methyl]phenyl][1,2]oxazolo[5,4-d]pyrimidin-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.00191

5-methyl-3-[[2-(1-piperidinyl)ethyl]thio]-5H-[1,2,4]triazino[5,6-b]indole

Homo sapiens

pH and temperature not specified in the publication

0.0014

5-methyl-6-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-3-phenyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0012

5-methyl-6-[4-[(morpholin-4-yl)methyl]phenyl]-3-phenyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.00052

5-[(4-hydroxyphenyl)methyl]-2-(4-phenylpiperazin-1-yl)-1,3-thiazol-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.00002

6-(3,4-dimethoxyphenyl)-3-(thiophen-2-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Homo sapiens

pH and temperature not specified in the publication

0.00062

6-chloro-5,7-dimethyl-N-[(2-methylphenyl)methyl][1,2,4]triazolo[1,5-a]pyrimidin-2-amine

Homo sapiens

pH and temperature not specified in the publication

0.001

6-ethenyl-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyrimidin-4(3H)-one

Homo sapiens

pH and temperature not specified in the publication

0.1

6-[4-[(4-benzylpiperidin-1-yl)methyl]phenyl]-5-methyl-3-phenyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

above, pH and temperature not specified in the publication

0.0009

6-[4-[(dimethylamino)methyl]phenyl]-5-methyl-3-phenyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one

Homo sapiens

pH and temperature not specified in the publication

0.0086

8-[4-(2-hydroxyphenyl)piperazin-1-yl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

Homo sapiens

pH and temperature not specified in the publication

0.0021

8-[4-(4-fluorophenyl)piperazin-1-yl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

Homo sapiens

pH and temperature not specified in the publication

0.000044

benzimidazole

Homo sapiens

pH and temperature not specified in the publication, recombinant enzyme

0.00085

ethyl 5-methyl-2-(pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate

Homo sapiens

pH and temperature not specified in the publication

0.0033

methyl 2-(4-methoxyphenyl)-3-methyl-4-oxo-3,4-dihydro[1]benzopyrano[3,4-b]pyrrole-1-carboxylate

Homo sapiens

pH and temperature not specified in the publication, recombinant enzyme

0.000095

methyl 4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)methyl)benzoate

Homo sapiens

pH 8.0, 22°C

0.00099

N-ethyl-2-nitro-5-[4-(2-thienylcarbonyl)-1-piperazinyl]aniline

Homo sapiens

pH and temperature not specified in the publication

0.000036

N-[(4-fluorophenyl)methyl]-6-[4-(2-methylpyridine-3-sulfonyl)piperazin-1-yl]pyridazine-3-carboxamide

Homo sapiens

pH and temperature not specified in the publication

0.00098

[4-(5a,9a-dihydro[1,2,4]triazolo[4,3-a]quinoxalin-4-yl)piperazin-1-yl](furan-2-yl)methanone

Homo sapiens

pH and temperature not specified in the publication

0.000047

[4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl][2,2'-(methylazanediyl-?N)di(acetato-?O)(2-)]boron

Homo sapiens

pH and temperature not specified in the publication

0.00081

[4-[3-(ethylamino)-4-nitrophenyl]piperazin-1-yl](2-methylphenyl)methanone

Homo sapiens

pH and temperature not specified in the publication

0.00091

[4-[3-(ethylamino)-4-nitrophenyl]piperazin-1-yl](4-ethylphenyl)methanone

Homo sapiens

pH and temperature not specified in the publication

0.0015

[4-[3-(ethylamino)-4-nitrophenyl]piperazin-1-yl](4-methoxyphenyl)methanone

Homo sapiens

pH and temperature not specified in the publication

0.0012

[4-[3-(ethylamino)-4-nitrophenyl]piperazin-1-yl](furan-2-yl)methanone

Homo sapiens

pH and temperature not specified in the publication

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Release 2023.1 (January 2023)