3.6.1.12: dCTP diphosphatase
This is an abbreviated version!
For detailed information about dCTP diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.12
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3.6.1.12
-
nudix
-
mutt
-
ap4a
-
diadenosine
-
decapping
-
dihydrate
-
triphosphorylated
-
dinucleoside
-
5',5'-p1,p4-tetraphosphate
-
8-oxo-dgtpase
-
exoribonuclease
-
8-oxo-2'-deoxyguanosine
-
5'-end-dependent
-
8-oxo-dgmp
-
drug development
-
medicine
- 3.6.1.12
-
nudix
-
mutt
- ap4a
-
diadenosine
-
decapping
-
dihydrate
-
triphosphorylated
-
dinucleoside
-
5',5'-p1,p4-tetraphosphate
- 8-oxo-dgtpase
- exoribonuclease
- 8-oxo-2'-deoxyguanosine
-
5'-end-dependent
- 8-oxo-dgmp
- drug development
- medicine
Reaction
Synonyms
all-alpha dCTP pyrophosphatase 1, all-alpha NTP pyrophosphatase, all-alpha nucleoside triphosphate pyrophosphatase, dCTP pyrophosphatase, dCTP pyrophosphatase 1, dCTPase, dCTPase 1, dCTPase-dUTPase, DCTPP1, deoxy-CTPase, deoxycytidine triphosphatase, deoxycytidine-triphosphatase, NTP pyrophosphatase, NTP pyrophosphohydrolase, phosphatase, deoxycytidine, tri-, pyrophosphohydrolase, RS21-C6, XTP3-TPA, XTP3-transactivated protein A, XTP3TPA
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Reference
Reference on EC 3.6.1.12 - dCTP diphosphatase
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Neale, G.A.M.; Mitchell, A.; Finch, L.R.
Enzymes of pyrimidine deoxyribonucleotide metabolism in Mycoplasma mycoides subsp. mycoides
J. Bacteriol.
156
1001-1005
1983
Mycoplasma mycoides
Allen, J.R.; Lasser, G.W.; Goldman, D.A.; Booth, J.W.; Mathews, C.K.
T4 phage deoxyribonucleotide-synthesizing enzyme complex. Further studies on enzyme composition and regulation
J. Biol. Chem.
258
5746-5753
1983
Tequatrovirus T4
Chiu, C.S.; Cook, K.S.; Greenberg, G.R.
Characteristics of a bacteriophage T4-induced complex synthesizing deoxyribonucleotide
J. Biol. Chem.
257
15087-15097
1982
Tequatrovirus T4
Zimmerman, S.B.; Kornberg, A.
Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Escherichia coli
J. Biol. Chem.
236
1480-1486
1961
Escherichia phage T2
Mosig, G.; Colowick, N.E.; Pietz, B.C.
Several new bacteriophage t4 genes, mapped by sequencing deletion endpoints between genes 56 (dCTPase) and dda (a DNA-dependent ATPase-helicase) modulate transcription
Gene
223
143-155
1998
Tequatrovirus T4
Gary, T.P.; Colowick, N.E.; Mosig, G.
A species barrier between bacteriophages T2 and T4: exclusion, join-copy and join-cut-copy recombination and mutagenesis in the dCTPase genes
Genetics
148
1461-1473
1998
Escherichia phage T2, Tequatrovirus T4
Corson, T.W.; Cavga, H.; Aberle, N.; Crews, C.M.
Triptolide directly inhibits dCTP pyrophosphatase
ChemBioChem
12
1767-1773
2011
Homo sapiens
Nonaka, M.; Tsuchimoto, D.; Sakumi, K.; Nakabeppu, Y.
Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine
FEBS J.
276
1654-1666
2009
Mus musculus (Q9QY93), Mus musculus
Requena, C.E.; Perez-Moreno, G.; Ruiz-Perez, L.M.; Vidal, A.E.; Gonzalez-Pacanowska, D.
The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells
Biochem. J.
459
171-180
2014
Homo sapiens (Q9H773), Homo sapiens
Zhang, Y.; Ye, W.Y.; Wang, J.Q.; Wang, S.J.; Ji, P.; Zhou, G.Y.; Zhao, G.P.; Ge, H.L.; Wang, Y.
dCTP pyrophosphohydrase exhibits nucleic accumulation in multiple carcinomas
Eur. J. Histochem.
57
e29
2013
Homo sapiens (Q9H773), Homo sapiens
Song, F.F.; Xia, L.L.; Ji, P.; Tang, Y.B.; Huang, Z.M.; Zhu, L.; Zhang, J.; Wang, J.Q.; Zhao, G.P.; Ge, H.L.; Zhang, Y.; Wang, Y.
Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation
Oncogenesis
4
e159
2015
Homo sapiens (Q9H773), Homo sapiens
Friese, A.; Kapoor, S.; Schneidewind, T.; Vidadala, S.R.; Sardana, J.; Brause, A.; Foerster, T.; Bischoff, M.; Wagner, J.; Janning, P.; Ziegler, S.; Waldmann, H.
Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling
Angew. Chem. Int. Ed. Engl.
58
13009-13013
2019
Homo sapiens (Q9H773)
Guiomar, P.; Andras, H.; Beata, G.; Luis, M.; Dolores, G.; Requena, C.; Vidal, A.
The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine
Biochem. J.
473
2635-2643
2016
Homo sapiens, Homo sapiens (Q9H773)
Llona-Minguez, S.; Haeggblad, M.; Martens, U.; Johansson, L.; Sigmundsson, K.; Lundbaeck, T.; Loseva, O.; Jemth, A.S.; Lundgren, B.; Jensen, A.J.; Scobie, M.; Helleday, T.
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2 pyridone- and pyrimidinone-derived systems
Bioorg. Med. Chem. Lett.
27
3219-3225
2017
Homo sapiens (Q9H773), Homo sapiens
Llona-Minguez, S.; Haeggblad, M.; Martens, U.; Throup, A.; Loseva, O.; Jemth, A.S.; Lundgren, B.; Scobie, M.; Helleday, T.
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1 triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines
Bioorg. Med. Chem. Lett.
27
3897-3904
2017
Homo sapiens (Q9H773), Homo sapiens
Martinez-Arribas, B.; Requena, C.E.; Perez-Moreno, G.; Ruiz-Perez, L.M.; Vidal, A.E.; Gonzalez-Pacanowska, D.
DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools
Cell. Mol. Life Sci.
77
1645-1660
2019
Homo sapiens (Q9H773), Homo sapiens
Llona-Minguez, S.; Hoeglund, A.; Jacques, S.A.; Johansson, L.; Calderon-Montano, J.M.; Claesson, M.; Loseva, O.; Valerie, N.C.K.; Lundbaeck, T.; Piedrafita, J.; Maga, G.; Crespan, E.; Meijer, L.; Moron, E.B.; Baranczewski, P.; Hagbjoerk, A.L.; Svensson, R.; Wiita, E.; Almloef, I.; Visnes, T.; Jeppsson, F.; Sigmundsson, K.; Jensen, A.J.; Artursson, P.; Jemth, A.-S.; Stenmark, P.; Berglund, U.W.; Scobie, M.; Helleday, T.
Discovery of the first potent and selective inhibitors of human dCTP pyrophosphatase 1
J. Med. Chem.
59
1140-1148
2016
Homo sapiens (Q9H773), Homo sapiens
Llona-Minguez, S.; Hoeglund, A.; Wiita, E.; Almloef, I.; Mateus, A.; Calderon-Montano, J.M.; Cazares-Koerner, C.; Homan, E.; Loseva, O.; Baranczewski, P.; Jemth, A.S.; Haeggblad, M.; Martens, U.; Lundgren, B.; Artursson, P.; Lundbaeck, T.; Jenmalm Jensen, A.; Warpman Berglund, U.; Scobie, M.; , H.
Identification of triazolothiadiazoles as potent inhibitors of the dCTP pyrophosphatase 1
J. Med. Chem.
60
2148-2154
2017
Homo sapiens (Q9H773)
Llona-Minguez, S.; Hoeglund, A.; Ghassemian, A.; Desroses, M.; Calderon-Montano, J.M.; Burgos Moron, E.; Valerie, N.C.K.; Wiita, E.; Almloef, I.; Koolmeister, T.; Mateus, A.; Cazares-Koerner, C.; Sanjiv, K.; Homan, E.; Loseva, O.; Baranczewski, P.; Darabi, M.; Mehdizadeh, A.; Fayezi, S.; Jemth, A.
Piperazin-1-ylpyridazine derivatives are a novel class of human dCTP pyrophosphatase 1 inhibitors
J. Med. Chem.
60
4279-4292
2017
Homo sapiens (Q9H773), Homo sapiens
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