3.6.1.12: dCTP diphosphatase

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For detailed information about dCTP diphosphatase, go to the full flat file.

Reaction

Synonyms

all-alpha dCTP pyrophosphatase 1, all-alpha NTP pyrophosphatase, all-alpha nucleoside triphosphate pyrophosphatase, dCTP pyrophosphatase, dCTP pyrophosphatase 1, dCTPase, dCTPase 1, dCTPase-dUTPase, DCTPP1, deoxy-CTPase, deoxycytidine triphosphatase, deoxycytidine-triphosphatase, NTP pyrophosphatase, NTP pyrophosphohydrolase, phosphatase, deoxycytidine, tri-, pyrophosphohydrolase, RS21-C6, XTP3-TPA, XTP3-transactivated protein A, XTP3TPA

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.12 dCTP diphosphatase

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Results	in table
2063	AA Sequence
4	Application
1	CAS Registry Number
8	Cloned(Commentary)
1	Crystallization (Commentary)
106	Disease/ Diagnostics
3	Expression
16	General Information
95	IC50 Value
175	Inhibitors
29	kcat/KM [mM/s]
5	Ki Value [mM]
32	KM Value [mM]
5	Localization
5	Metals/Ions
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
21	Organism
5	Pathway
16	PDB ID
2	pH Optimum
2	pH Range
4	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
20	Reference
13	Source Tissue
1	Specific Activity [micromol/min/mg]
50	Substrates and Products (Substrate)
4	Subunits
39	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
29	Turnover Number [1/s]

Expression

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Expression on EC 3.6.1.12 - dCTP diphosphatase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

exposure of HeLa cells to decitabine upregulates the expression of several pyrimidine metabolic enzymes including DCTPP1, dUTPase, dCMP deaminase and thymidylate synthase

Homo sapiens

Q9H773

755999

exposure of HeLa or MRC-5 cells to decitabine (5-aza-2'-deoxycytidine, aza-dCyd), an anti-cancer drug, upregulates the expression of several pyrimidine metabolic enzymes including DCTPP1, dUTPase, dCMP deaminase and thymidylate synthase, thus suggesting their contribution to the cellular response to this anti-cancer nucleoside

Homo sapiens

Q9H773

755999

neither knockdown nor over-expression of DCTPP1 significantly modifies the fraction of anti-BrdU reactive cells

Homo sapiens

-

719287