3.5.4.36: mRNA(cytosine6666) deaminase
This is an abbreviated version!
For detailed information about mRNA(cytosine6666) deaminase, go to the full flat file.
Word Map on EC 3.5.4.36
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3.5.4.36
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cytidine
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polypeptide-like
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deamination
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deaminases
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apobecs
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hypermutation
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editosome
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c-to-u
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mooring
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apob48
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apob100
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rna-specific
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unedited
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mcardle
- 3.5.4.36
- cytidine
-
polypeptide-like
-
deamination
- deaminases
-
apobecs
-
hypermutation
-
editosome
-
c-to-u
-
mooring
-
apob48
-
apob100
-
rna-specific
-
unedited
-
mcardle
Reaction
Synonyms
apo B messenger RNA editing protein, apoB mRNA-editing enzyme catalytic polypeptide 1, APOBEC-1, APOBEC1, apolipoprotein B mRNA editing enzyme, apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1, REPR
ECTree
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Metals Ions
Metals Ions on EC 3.5.4.36 - mRNA(cytosine6666) deaminase
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NaCl
optimal activity of APOBEC1 without auxiliary factor at 80 mM ionic strength, optimal activity of APOBEC1 in presence of the auxiliary factor ACF at 90 mM
Zinc
Zinc
the enzyme requires zinc for its catalytic activity. A zinc motif is essential for catalytic activity. His61, Cys93, and Cys96 are essential for editing activity, probably because they coordinate zinc
Zinc
the enzyme contains tightly bound zinc, zinc exhibits a specific role in apoB mRNA editing
Zinc
the zinc finger in p27 may be required for catalysis, protein-protein interactions, or binding to apoB mRNA
Zinc
-
zinc binding is required for both apoB RNA editing and cytidine deaminase activity
Zinc
zinc-dependent enzyme. The amino acids His61, Cys93, and Cys96 chelate zinc