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Literature summary for 3.5.4.36 extracted from
- Biosynthesis of apolipoprotein B48-containing lipoproteins. Regulation by novel post-transcriptional mechanisms (1996), J. Biol. Chem., 271, 2353-2536.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zinc | zinc-dependent enzyme. The amino acids His61, Cys93, and Cys96 chelate zinc | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine6666 in apolipoprotein B mRNA + H2O | Mus musculus | the enzyme specifically catalyzes the deamination of cytidine at position 6666 in apolipoprotein B mRNA to form an uridine. This changes the codon at position 2153 from a genomically encoded CAA (glutamine) to an in-frame stop codon. Apolipoprotein B mRNA editing occurs in the small intestines of all mammals and in the livers of rats, mice, dogs, and horses. Hepatic editing activity is regulated by growth hormone, thyroxine, cortisol, fasting, and diet | uracil6666 in apolipoprotein B mRNA + NH3 | - |
? | |
| cytosine6666 in apolipoprotein B mRNA + H2O | Rattus norvegicus | the enzyme specifically catalyzes the deamination of cytidine at position 6666 in apolipoprotein B mRNA to form an uridine. This changes the codon at position 2153 from a genomically encoded CAA (glutamine) to an in-frame stop codon. Apolipoprotein B mRNA editing occurs in the small intestines of all mammals and in the livers of rats, mice, dogs, and horses. Hepatic editing activity is regulated by growth hormone, thyroxine, cortisol, fasting, and diet | uracil6666 in apolipoprotein B mRNA + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P51908 | - |
- |
| Rattus norvegicus | P38483 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon | low level | Rattus norvegicus | - |
| heart | low level | Mus musculus | - |
| kidney | low level | Mus musculus | - |
| kidney | low level | Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| lung | low level | Mus musculus | - |
| lung | low level | Rattus norvegicus | - |
| muscle | low level | Mus musculus | - |
| small intestine | - |
Mus musculus | - |
| small intestine | - |
Rattus norvegicus | - |
| spleen | - |
Mus musculus | - |
| spleen | low level | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine6666 in apolipoprotein B mRNA + H2O | - |
Mus musculus | uracil6666 in apolipoprotein B mRNA + NH3 | - |
? | |
| cytosine6666 in apolipoprotein B mRNA + H2O | the enzyme specifically catalyzes the deamination of cytidine at position 6666 in apolipoprotein B mRNA to form an uridine. This changes the codon at position 2153 from a genomically encoded CAA (glutamine) to an in-frame stop codon. Apolipoprotein B mRNA editing occurs in the small intestines of all mammals and in the livers of rats, mice, dogs, and horses. Hepatic editing activity is regulated by growth hormone, thyroxine, cortisol, fasting, and diet | Mus musculus | uracil6666 in apolipoprotein B mRNA + NH3 | - |
? | |
| cytosine6666 in apolipoprotein B mRNA + H2O | the enzyme specifically catalyzes the deamination of cytidine at position 6666 in apolipoprotein B mRNA to form an uridine. This changes the codon at position 2153 from a genomically encoded CAA (glutamine) to an in-frame stop codon. Apolipoprotein B mRNA editing occurs in the small intestines of all mammals and in the livers of rats, mice, dogs, and horses. Hepatic editing activity is regulated by growth hormone, thyroxine, cortisol, fasting, and diet | Rattus norvegicus | uracil6666 in apolipoprotein B mRNA + NH3 | - |
? | |
| cytosine6666 in apolipoprotein B mRNA + H2O | the enzyme is not able to edit apoB RNA in vitro without the addition of complementary or auxiliary proteins | Rattus norvegicus | uracil6666 in apolipoprotein B mRNA + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| apoB mRNA-editing enzyme catalytic polypeptide 1 | catalytic subunit of the apoB mRNA editing complex | Mus musculus |
| apoB mRNA-editing enzyme catalytic polypeptide 1 | catalytic subunit of the apoB mRNA editing complex | Rattus norvegicus |
| APOBEC-1 | catalytic subunit of the apoB mRNA editing complex | Mus musculus |
| APOBEC-1 | catalytic subunit of the apoB mRNA editing complex | Rattus norvegicus |
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