Cloned (Comment) | Organism |
---|---|
expression in COS-7 cells | Oryctolagus cuniculus |
Protein Variants | Comment | Organism |
---|---|---|
C93A | the mutant retains 4% of wild-type editing activity | Oryctolagus cuniculus |
C96A | mutant lacks activity | Oryctolagus cuniculus |
E63A | mutant lacks activity | Oryctolagus cuniculus |
H61A | mutant lacks activity | Oryctolagus cuniculus |
H61C | mutant shows 80% of wild-type editing activity | Oryctolagus cuniculus |
additional information | the truncated mutant form of the rabbit REPR that lacks the COOH-terminal one-third containing the putative leucine-rich motif is catalytically inactive | Oryctolagus cuniculus |
P92A | the mutant retains 18% of wild-type editing activity | Oryctolagus cuniculus |
V62A | the mutant retains 89% of wild-type editing activity | Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zinc | the enzyme requires zinc for its catalytic activity. A zinc motif is essential for catalytic activity. His61, Cys93, and Cys96 are essential for editing activity, probably because they coordinate zinc | Oryctolagus cuniculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
28000 | - |
calculated from nucleotide sequence | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | P47855 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine6666 in apolipoprotein B mRNA + H2O | auxiliary proteins of the apoB mRNA editing complex, which are essential for editing activity, exist in organs devoid of significant apoB mRNA editing or apoB synthesis | Oryctolagus cuniculus | uracil6666 in apolipoprotein B mRNA + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
REPR | - |
Oryctolagus cuniculus |