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Literature summary for 3.5.4.36 extracted from

  • Yamanakam, S.; Poksay, K.S.; Balestra, M.E.; Zeng, G.Q.; Innerarity, T.L.
    Cloning and mutagenesis of the rabbit ApoB mRNA editing protein. A zinc motif is essential for catalytic activity, and noncatalytic auxiliary factor(s) of the editing complex are widely distributed (1994), J. Biol. Chem., 269, 21725-21734.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cells Oryctolagus cuniculus

Protein Variants

Protein Variants Comment Organism
C93A the mutant retains 4% of wild-type editing activity Oryctolagus cuniculus
C96A mutant lacks activity Oryctolagus cuniculus
E63A mutant lacks activity Oryctolagus cuniculus
H61A mutant lacks activity Oryctolagus cuniculus
H61C mutant shows 80% of wild-type editing activity Oryctolagus cuniculus
additional information the truncated mutant form of the rabbit REPR that lacks the COOH-terminal one-third containing the putative leucine-rich motif is catalytically inactive Oryctolagus cuniculus
P92A the mutant retains 18% of wild-type editing activity Oryctolagus cuniculus
V62A the mutant retains 89% of wild-type editing activity Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc the enzyme requires zinc for its catalytic activity. A zinc motif is essential for catalytic activity. His61, Cys93, and Cys96 are essential for editing activity, probably because they coordinate zinc Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
calculated from nucleotide sequence Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus P47855
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine6666 in apolipoprotein B mRNA + H2O auxiliary proteins of the apoB mRNA editing complex, which are essential for editing activity, exist in organs devoid of significant apoB mRNA editing or apoB synthesis Oryctolagus cuniculus uracil6666 in apolipoprotein B mRNA + NH3
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Synonyms

Synonyms Comment Organism
REPR
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Oryctolagus cuniculus