Disease on EC 3.5.4.36 - mRNA(cytosine6666) deaminase
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Adenoma
Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice.
Atherosclerosis
Assessment of Novel Antioxidant Therapy in Atherosclerosis by Contrast Ultrasound Molecular Imaging.
Atherosclerosis
Curcumin regulates the metabolism of low density lipoproteins by improving the C-to-U RNA editing efficiency of apolipoprotein B in primary rat hepatocytes.
Atherosclerosis
Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
Atherosclerosis
Molecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype.
Atherosclerosis
Molecular Imaging of Platelet-Endothelial Interactions and Endothelial von Willebrand Factor in Early and Mid-Stage Atherosclerosis.
Atherosclerosis
Molecular Imaging of the Initial Inflammatory Response in Atherosclerosis. Implications for Early Detection of Disease.
Brain Ischemia
Apobec-1 increases cyclooxygenase-2 and aggravates injury in oxygen-deprived neurogenic cells and middle cerebral artery occlusion rats.
Breast Neoplasms
APOBEC3B gene expression as a novel predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer.
Breast Neoplasms
Durable Complete Response With Immune Checkpoint Inhibitor in Breast Cancer With High Tumor Mutational Burden and APOBEC Signature.
Carcinogenesis
A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme.
Carcinogenesis
An alternatively spliced form of apobec-1 messenger RNA is overexpressed in human colon cancer.
Carcinogenesis
Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs.
Carcinogenesis
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like family genes activation and regulation during tumorigenesis.
Carcinogenesis
Excessive activity of apolipoprotein B mRNA editing enzyme catalytic popypeptide 2 (APOBEC2) contiributes to liver and lung tumorigenesis.
Carcinogenesis
[Molecular mechanism and research progress of hepatocellular carcinoma induced by hepatitis B virus mutation].
Carcinoma
A1CF-promoted colony formation and proliferation of RCC depends on DKK1-MEK/ERK signal axis.
Carcinoma, Hepatocellular
APOBEC3B: A Potential Factor Suppressing Growth of Human Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Apolipoprotein B RNA sequence 3' of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing.
Carcinoma, Hepatocellular
Cloning and characterization of the rat apobec-1 gene: a comparative analysis of gene structure and promoter usage in rat and mouse.
Carcinoma, Hepatocellular
Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity.
Carcinoma, Hepatocellular
Distinct promoters induce APOBEC-1 expression in rat liver and intestine.
Carcinoma, Hepatocellular
Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells.
Carcinoma, Hepatocellular
In vitro reconstitution of apolipoprotein B RNA editing activity from recombinant APOBEC-1 and McArdle cell extracts.
Carcinoma, Hepatocellular
Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
Carcinoma, Hepatocellular
Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing.
Carcinoma, Hepatocellular
Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing.
Carcinoma, Hepatocellular
Recapture of hepatic apolipoprotein B mRNA editing may be a promising strategy to relieve nephrotic dyslipidemia.
Carcinoma, Hepatocellular
Two efficiency elements flanking the editing site of cytidine 6666 in the apolipoprotein B mRNA support mooring-dependent editing.
Carcinoma, Renal Cell
A1CF-promoted colony formation and proliferation of RCC depends on DKK1-MEK/ERK signal axis.
Cervical Intraepithelial Neoplasia
Hypermutation in the E2 gene of human papillomavirus type 16 in cervical intraepithelial neoplasia.
Colonic Neoplasms
An alternatively spliced form of apobec-1 messenger RNA is overexpressed in human colon cancer.
Colonic Neoplasms
Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs.
Colonic Neoplasms
Cloning and characterization of the rat apobec-1 gene: a comparative analysis of gene structure and promoter usage in rat and mouse.
Gallstones
Decreased expression of cholesterol 7alpha hydroxylase and altered bile acid metabolism in Apobec-1 -/- mice leads to increased gallstone susceptibility.
Glycogen Storage Disease Type VI
Durable Complete Response With Immune Checkpoint Inhibitor in Breast Cancer With High Tumor Mutational Burden and APOBEC Signature.
Hepatitis B
Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.
Hepatitis B
Distribution and difference of APOBEC-induced mutations in the TpCpW context of HBV DNA between HCC and non-HCC.
Hepatitis B, Chronic
[Association between APOBEC3G polymorphisms and susceptibility to chronic hepatitis B].
Hypercholesterolemia
Apolipoprotein B mRNA editing and the reduction in synthesis and secretion of the atherogenic risk factor, apolipoprotein B100 can be effectively targeted through TAT-mediated protein transduction.
Hypercholesterolemia
Hepatic expression of the catalytic subunit of the apolipoprotein B mRNA editing enzyme (apobec-1) ameliorates hypercholesterolemia in LDL receptor-deficient rabbits.
Hypercholesterolemia
Normal perinatal rise in serum cholesterol is inhibited by hepatic delivery of adenoviral vector expressing apolipoprotein B mRNA editing enzyme (Apobec1) in rabbits.
Hypercholesterolemia
Phenotype interaction of apobec-1 and CETP, LDLR, and apoE gene expression in mice: role of apoB mRNA editing in lipoprotein phenotype expression.
Hyperinsulinism
Apolipoprotein B mRNA editing and apolipoprotein gene expression in the liver of hyperinsulinemic fatty Zucker rats: relationship to very low density lipoprotein composition.
Infarction, Middle Cerebral Artery
Apobec-1 increases cyclooxygenase-2 and aggravates injury in oxygen-deprived neurogenic cells and middle cerebral artery occlusion rats.
Infections
Hepatic gene transfer of the catalytic subunit of the apolipoprotein B mRNA editing enzyme results in a reduction of plasma LDL levels in normal and watanabe heritable hyperlipidemic rabbits.
Infections
Hypermutation in the E2 gene of human papillomavirus type 16 in cervical intraepithelial neoplasia.
Infections
Repair of APOBEC3G-mutated retroviral DNA in vivo is facilitated by the host enzyme uracil DNA glycosylase 2.
Infections
[The associations between polymorphisms of APOBEC3G and different outcomes of persistent HBV infection]
mrna(cytosine6666) deaminase deficiency
Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec-1.
Myocardial Infarction
Echocardiographic Molecular Imaging of the Effect of Anticytokine Therapy for Atherosclerosis.
Neoplasms
An alternatively spliced form of apobec-1 messenger RNA is overexpressed in human colon cancer.
Neoplasms
Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs.
Neoplasms
APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.
Neoplasms
APOBEC3B High Expression in Gastroenteropancreatic Neuroendocrine Neoplasms and Association With Lymph Metastasis.
Neoplasms
APOBEC3B: A Potential Factor Suppressing Growth of Human Hepatocellular Carcinoma Cells.
Neoplasms
Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism.
Neoplasms
C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.
Neoplasms
Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.
Neoplasms
Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice.
Neoplasms
Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif.
Neoplasms
Hypermutation in the E2 gene of human papillomavirus type 16 in cervical intraepithelial neoplasia.
Neoplasms
Identification of aberrantly methylated differentially expressed genes in glioblastoma multiforme and their association with patient survival.
Neoplasms
Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
Neoplasms
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.
Neoplasms
The Prognostic Significance of APOBEC3B and PD-L1/PD-1 in Nasopharyngeal Carcinoma.
Neurofibromatosis 1
C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.
Obesity
Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes.
Psoriasis
Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.
Retroviridae Infections
APOBEC3G/3A Expression in Human Immunodeficiency Virus Type 1-Infected Individuals Following Initiation of Antiretroviral Therapy Containing Cenicriviroc or Efavirenz.
Squamous Cell Carcinoma of Head and Neck
HPV Meets APOBEC: New Players in Head and Neck Cancer.
Urinary Bladder Neoplasms
Tumor?infiltrating M2 macrophages driven by specific genomic alterations are associated with prognosis in bladder cancer.
Virus Diseases
Family-Wide Comparative Analysis of Cytidine and Methylcytidine Deamination by Eleven Human APOBEC Proteins.
Virus Diseases
Viral (hepatitis C virus, hepatitis B virus, HIV) persistence and immune homeostasis.
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