3.5.4.36: mRNA(cytosine6666) deaminase
This is an abbreviated version!
For detailed information about mRNA(cytosine6666) deaminase, go to the full flat file.
Word Map on EC 3.5.4.36
-
3.5.4.36
-
cytidine
-
polypeptide-like
-
deamination
-
deaminases
-
apobecs
-
hypermutation
-
editosome
-
c-to-u
-
mooring
-
apob48
-
apob100
-
rna-specific
-
unedited
-
mcardle
- 3.5.4.36
- cytidine
-
polypeptide-like
-
deamination
- deaminases
-
apobecs
-
hypermutation
-
editosome
-
c-to-u
-
mooring
-
apob48
-
apob100
-
rna-specific
-
unedited
-
mcardle
Reaction
Synonyms
apo B messenger RNA editing protein, apoB mRNA-editing enzyme catalytic polypeptide 1, APOBEC-1, APOBEC1, apolipoprotein B mRNA editing enzyme, apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1, REPR
ECTree
3.5.4.36 mRNA(cytosine6666) deaminaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.5.4.36 - mRNA(cytosine6666) deaminase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-methylcytosine in single-stranded DNA + H2O
thymine in single-stranded DNA + NH3
Apobec1 has 5-methylcytosine deaminase activity, resulting in a thymine base opposite a guanine. If this mismatch is repaired, a methylated cytosine is replaced by an unmethylated one. If it is not repaired, it results in a cytosine -> thymine transition mutation. Apobec1, and perhaps other members of this protein family play a role in epigenetic reprogramming
-
-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
murine APOBEC1 is a hypermutator of both RNA and ssDNA in vivo
-
-
?
cytosine in RNA + H2O
uracil in RNA + NH3
murine APOBEC1 is a hypermutator of both RNA and ssDNA in vivo
-
-
?
cytosine in RNA + H2O
uracil in RNA + NH3
transcriptome-wide sequencing reveals numerous APOBEC1 mRNA editing targets in transcript 3' untranslated regions, a molecular mechanism that suggests additional roles for APOBEC1 beyond its function in apolipoprotein regulation
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
-
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
APOBEC1, catalytic component of an RNA-editing complex, transports the complementing specificity factor ACF to and from the nucleus as cargo. Expression of APOBEC1 alone edits apoB RNA and generates a substrate for nonsense-mediated decay. The APOBEC1/ACF editing complex protects the edited apoB RNA from nonsense-mediated decay and transports the RNA to the cytoplasm for translation
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
apolipoprotein (apo)B mRNA editing is mediated by a multiprotein editosome complex. Apobec-1 is the catalytic component of this complex. ABBP-1 (apobec-1-binding protein-1) is an apobec-1-interacting protein that may play an important role in apoB mRNA editing
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
-
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
-
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
intestine-specific expression of Apobec-1 rescues apolipoprotein B RNA editing and alters chylomicron production in Apobec1-/- mice
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
murine APOBEC1 is a hypermutator of both RNA and ssDNA in vivo
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
the enzyme specifically catalyzes the deamination of cytidine at position 6666 in apolipoprotein B mRNA to form an uridine. This changes the codon at position 2153 from a genomically encoded CAA (glutamine) to an in-frame stop codon. Apolipoprotein B mRNA editing occurs in the small intestines of all mammals and in the livers of rats, mice, dogs, and horses. Hepatic editing activity is regulated by growth hormone, thyroxine, cortisol, fasting, and diet
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
-
apolipoprotein B mRNA editing at nucleotide 6666 converts cytidine to uridine, transforming the codon for glutamine-2153 to a termination codon
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
-
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
mammalian apolipoprotein B (apo B) exists in two forms, each the product of a single gene. The shorter form, apo B48, arises by posttranscriptional RNA editing whereby cytidine deamination produces a UAA termination codon
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
the enzyme specifically catalyzes the deamination of cytidine at position 6666 in apolipoprotein B mRNA to form an uridine. This changes the codon at position 2153 from a genomically encoded CAA (glutamine) to an in-frame stop codon. Apolipoprotein B mRNA editing occurs in the small intestines of all mammals and in the livers of rats, mice, dogs, and horses. Hepatic editing activity is regulated by growth hormone, thyroxine, cortisol, fasting, and diet
-
-
?
