3.5.1.3: omega-amidase

This is an abbreviated version!
For detailed information about omega-amidase, go to the full flat file.

Word Map on EC 3.5.1.3

3.5.1.3

alpha-ketoglutaramate

asparagine

transamination

ammonia

oxaloacetate

succinamate

glutaminase

transamidase

analysis

medicine

biotechnology

Reaction

Synonyms

alpha-keto acid omega-amidase, alpha-keto acid-omega-amidase, amidase, omega, dicarboxylate omega-amidase, NIT2, Nit2/omega-amidase, nitrilase-like protein 2, omega-amidase, omega-amidase/Nit2, omega-amido dicarboxylate amidohydrolase, omega-amidodicarboxylate amidohydrolase

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.3 omega-amidase

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Results	in table
8	Activating Compound
208	AA Sequence
4	Application
1	CAS Registry Number
7	Cloned(Commentary)
3	Cofactor
5	Disease/ Diagnostics
14	General Information
4	General Stability
36	Inhibitors
11	kcat/KM [mM/s]
63	KM Value [mM]
35	Localization
9	Metals/Ions
17	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
271	Organism
1	Oxidation Stability
9	Pathway
36	pH Optimum
5	pH Stability
15	Purification (Commentary)
10	Reaction
2	Reaction Type
45	Reference
1	Renatured (Commentary)
84	Source Tissue
18	Specific Activity [micromol/min/mg]
5	Storage Stability
272	Substrates and Products (Substrate)
8	Subunits
19	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
11	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.5.1.3 - omega-amidase

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2,2,2-Trifluoroethanol

Rattus norvegicus

more than 2 M: irreversible inactivation

288888

2-Chloroethanol

Rattus norvegicus

more than 2 M: irreversible inactivation

288888

5,5'-dithiobis-(2-nitrobenzoic acid)

2 entries

6-diazo-5-oxo-L-norleucine

Neurospora crassa

DON, completely

288885

alpha-ketosuccinamate

Neurospora crassa

10 mM: 75% inhibition

288885

dioxane

Rattus norvegicus

up to 5% dioxane: no effect on hydrolysis of ethyl alpha-keto-glutarate or glutaramate, at 10% dioxane: slight, 5-10% inhibition

288888

ethanol

2 entries

Glutaramate

Rattus norvegicus

competitive inhibition, 10 mM glutaramate, hydrolysis of methyl alpha-ketoglutarate: 43% inhibition, hydrolysis of ethyl alpha-ketoglutarate: 34% inhibition

288892

glycylglycine

Rattus norvegicus

competitive inhibitor, Ki: 5 mM

iodoacetamide

iodoacetate

methylamine

N-ethylmaleimide

NH4+

p-mercuribenzoate

phosphate

succinamate

competitive inhibition, 5 mM succinamate, hydrolysis of methyl alpha-ketoglutarate: 57% inhibition, hydrolysis of ethyl alpha-ketoglutarate: 42% inhibition

288892

sulfhydryl reagents

Rattus norvegicus

288884, 288892

additional information

5 entries