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3.5.1.11: penicillin amidase

This is an abbreviated version!
For detailed information about penicillin amidase, go to the full flat file.

Word Map on EC 3.5.1.11

Reaction

penicillin
+
H2O
=
a carboxylate
 +
6-aminopenicillanate

Synonyms

ACPGA001 PGA, AfPGA, alpha-acylamino-beta-lactam acylhydrolase, amidase, amidohydrolase, ampicillin acylase, AuAAC, benzylpenicillin acylase, BmPGA, Eca3205, KcPGA, maPGA, More, novozym 217, PA, PAC, penicillin acylase, penicillin amidase, Penicillin amidohydrolase, penicillin G acylase, Penicillin G amidase, Penicillin G amidohydrolase, penicillin V acylase, Penicillin V amidase, penicillin-G acylase, PGA, PGA650, PVA, semacylase, Sm-PVA, YxeI

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.11 penicillin amidase

Temperature Range

Temperature Range on EC 3.5.1.11 - penicillin amidase

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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20 - 50
20 - 60
25 - 75
activity range
30 - 35
-
-
30 - 45
-
30°C: about 60% of maximal activity, 45°C: about 45% of maximal activity
30 - 60
30 - 70
35 - 60
35°C: about 60% of maximal activity, 60°C: about 35% of maximal activity
37
-
75% of maximum activity
40 - 60
40°C: about 40% of maximal activity, 60°C: about 40% of maximal activity, mutant enzyme T63S/S110C/N198Y
40 - 65
40°C: about 40% of maximal activity, 65°C: about 50% of maximal activity, wild-type enzyme