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3.5.1.11: penicillin amidase

This is an abbreviated version!
For detailed information about penicillin amidase, go to the full flat file.

Word Map on EC 3.5.1.11

Reaction

penicillin
+
H2O
=
a carboxylate
 +
6-aminopenicillanate

Synonyms

ACPGA001 PGA, AfPGA, alpha-acylamino-beta-lactam acylhydrolase, amidase, amidohydrolase, ampicillin acylase, AuAAC, benzylpenicillin acylase, BmPGA, Eca3205, KcPGA, maPGA, More, novozym 217, PA, PAC, penicillin acylase, penicillin amidase, Penicillin amidohydrolase, penicillin G acylase, Penicillin G amidase, Penicillin G amidohydrolase, penicillin V acylase, Penicillin V amidase, penicillin-G acylase, PGA, PGA650, PVA, semacylase, Sm-PVA, YxeI

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.11 penicillin amidase

Turnover Number

Turnover Number on EC 3.5.1.11 - penicillin amidase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.2
(R) -2-(4-hydroxyphenyl)glycine amide
-
-
1.01 - 6.08
(S)-N-acetylphenylglycine
0.1
2-benzoxazolon-3-yl-acetic acid methyl ester
-
pH 6.8, 25°C
106.4
2-nitro-5-phenoxyacetamide benzoic acid
-
0.204 - 15
2-nitro-5-[(phenyl-acetyl)amino]benzoic acid
15.7 - 145.3
2-nitro-5-[(phenylacetyl)amino]-benzoic acid
40.03
2-phenyl-N-(4-sulfamoylphenyl)acetamide
-
pH 7.0, 25°C
2.3
2-phenylacetamidobenzoic acid
-
25°C, pH 7.0, 10% dimethylsulfoxide
2.5
3-phenylacetamidobenzoic acid
-
25°C, pH 7.0, 10% dimethylsulfoxide
29 - 47
4-Hydroxyphenylacetamide
170
4-nitrophenyl acetate
-
-
3
4-phenylacetamidobenzoic acid
-
25°C, pH 7.0, 10% dimethylsulfoxide
0.9 - 1.2
5-nitro-3-[(phenylacetyl)amino]benzoic acid
58.3
6-nitro-3-(phenylacetamido)-benzoic acid
pH 7.4, 37°C, recombinant enzyme
20 - 82
6-nitro-3-phenylacetamidobenzoic acid
16 - 68.8
6-nitro-3-[(phenylacetyl)amino]benzoic acid
50
7-phenylacetamidoacetoxycephalosporanic acid
-
-
14.67 - 142.3
amoxicillin
56.2
amoxycillin
pH 7.4, 37°C, recombinant enzyme
11 - 49.5
ampicillin
21 - 190
benzylpenicillin
40
benzylpenicilloic acid
-
-
63.7
carbenicillin
pH 7.4, 37°C, recombinant enzyme
13 - 32
cefadroxil
20 - 54
cephalexin
33 - 66.9
cephaloridine
25 - 78.3
cephalothin
0.54
D-(-)-alpha-aminophenylacetic acid 4-nitroanilide
-
-
12 - 14
D-2-nitro-5-[(phenylacetyl)amino]benzoic acid
2 - 16
D-4-hydroxyphenylglycine amide
11.61 - 102.6
D-hydroxyphenylglycine methyl ester
-
2.7 - 57
D-phenylglycine amide
170
ethyl 2-phenylacetate
-
-
-
41.05
ethyl 4-[(phenylacetyl)amino] benzoate
-
pH 7.0, 25°C
49.17
N,2-diphenylacetamide
-
pH 7.0, 25°C
35.94
N-(4-acetylphenyl)-2-phenylacetamide
-
pH 7.0, 25°C
43.07
N-(4-bromophenyl)-2-phenylacetamide
-
pH 7.0, 25°C
33.84
N-(4-cyanophenyl)-2-phenylacetamide
-
pH 7.0, 25°C
33.81
N-(4-methoxyphenyl)-2-phenylacetamide
-
pH 7.0, 25°C
37.93
N-(4-methylphenyl)-2-phenylacetamide
-
pH 7.0, 25°C
15.14
N-(4-nitrophenyl)-2-phenylacetamide
-
pH 7.0, 25°C
7.8
N-(5-nitro-2-pyridyl)-phenylacetamide
-
25°C, pH 7.0, 10% dimethylsulfoxide
12000
N-phenylacetyl-Glu
-
-
29.49
N-[4-(methylsulfonyl)phenyl]-2-phenylacetamide
-
pH 7.0, 25°C
18
N2-phenylacetyl-2'-deoxyguanosine
-
pH 7.8, 25°C
2
N6-phenylacetyl-2'-deoxyadenosine
-
pH 7.8, 25°C
4.2 - 14.75
penicillin dihydroF
1.9 - 3.33
penicillin F
0.02 - 72.7
penicillin G
0.32 - 35.58
penicillin K
6.38 - 270.8
Penicillin V
23 - 50
phenylacetamide
20 - 55
phenylacetate 4-nitroanilide
1.9
phenylacetyl-2-naphthylamide
-
25°C, pH 7.0, 10% dimethylsulfoxide
3.2
phenylacetyl-7-amido-4-methylcoumarin
-
25°C, pH 7.0, 10% dimethylsulfoxide
47
phenylacetyl-Gly
-
pH 7.8, 25°C
35
phenylacetylaspartame
-
pH 7.8, 25°C
additional information
additional information
-
temperature dependence of turnover-numer for R- and S-p-hydroxyphenylglycineamide
-