3.4.99.B1: RCE1
This is an abbreviated version!
For detailed information about RCE1, go to the full flat file.
Word Map on EC 3.4.99.B1
Reaction
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins =
Synonyms
At Rce1p, hRCE1, Hs Rce1p, human Ras-converting enzyme, isoprenylated protein peptidase, RACE, Ras and a-factor converting enzyme, Ras converting enzyme, Ras converting enzyme 1, Ras-converting enzyme, Ras-converting enzyme 1, RCE1, Rce1p, Sc Rce1p, type II CAAX protease
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3.4.99.B1 RCE1Advanced search results
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Natural Substrates Products on EC 3.4.99.B1 - RCE1
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Ras-CaaX + H2O
Ras-C + aaX
-
a stands for aliphatic amino acid, X is any amino acid
-
?
Ras2 + H2O
Ras2-C + aaX
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a stands for aliphatic amino acid, X is any amino acid
-
?
a-factor-CaaX + H2O
a-factor-C + aaX
-
a stands for aliphatic amino acid, X is any amino acid
-
?
a-factor-CaaX + H2O
a-factor-C + aaX
-
a stands for aliphatic amino acid, X is any amino acid
-
?
a-factor-CaaX + H2O
a-factor-C + aaX
-
removal of the last three amino acids of carboxyl-terminal sequence motif CaaX, enzyme proteolyzes a-factor with A, V, L, I, C or M at the a1 position, V, L, I, C or M at the a2 position or any amino acid at the X position
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?
additional information
?
-
-
the enzyme is responsible for one step in Ras membrane localization
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-
?
additional information
?
-
-
in the absence of Rce1, splenocytes and bone marrow cells expressing oncogenic KRAS yield more and larger colonies when grown in methylcellulose. The inactivation of Rce1 worsens the myeloproliferative disease caused by oncogenic K-RAS
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-
?
additional information
?
-
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the Trypanosoma brucei RCE1 ortholog appears to be the dominant prenyl-CaaX protease
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?
