3.4.99.B1: RCE1
This is an abbreviated version!
For detailed information about RCE1, go to the full flat file.
Reaction
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins =
Synonyms
At Rce1p, hRCE1, Hs Rce1p, human Ras-converting enzyme, isoprenylated protein peptidase, RACE, Ras and a-factor converting enzyme, Ras converting enzyme, Ras converting enzyme 1, Ras-converting enzyme, Ras-converting enzyme 1, RCE1, Rce1p, Sc Rce1p, type II CAAX protease
ECTree
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General Information
General Information on EC 3.4.99.B1 - RCE1
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malfunction
metabolism
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the deubiquitinating enzyme USP17 negatively regulates the activity of RCE1
physiological function
rce1-deficient cells are highly sensitive toward calcofluor white. Because rce1-deficient single mutants still exhibit a halo due to the activity of the remaining CaaX protease, they are almost indistinguishable from wild type cells. In rce1/ste24 double deletion mutants, no halos are visible
malfunction
retinal development proceeds normally in the absence of RAS-converting enzyme 1 (Rce1), but photoreceptor cells fail to respond to light and subsequently degenerate in a rapid fashion. Phosphodiesterase 6 is unable to be transported to the outer segments in Rce1-deficient photoreceptor cells
malfunction
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rce1-deficient cells are highly sensitive toward calcofluor white. Because rce1-deficient single mutants still exhibit a halo due to the activity of the remaining CaaX protease, they are almost indistinguishable from wild type cells. In rce1/ste24 double deletion mutants, no halos are visible
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RCE1 is involved in Ras trafficking to the plasma membrane and the Ras/MEK/ERK pathway. USP17 regulation of growth is RCE1-dependent, overview
physiological function
RCE1 is essential for the intracellular trafficking of phosphodiesterase 6 and survival of photoreceptor cells
physiological function
both Ras-like small GTPases RalA and RalB require Ras converting CAAX endopeptidase 1 (RCE1) for association with the plasma membrane, albeit not with endomembranes, and loss of RCE1 causes mislocalization as well as sustained activation of both RalA and RalB