3.4.99.B1: RCE1

This is an abbreviated version!
For detailed information about RCE1, go to the full flat file.

Reaction

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins =

Synonyms

At Rce1p, hRCE1, Hs Rce1p, human Ras-converting enzyme, isoprenylated protein peptidase, RACE, Ras and a-factor converting enzyme, Ras converting enzyme, Ras converting enzyme 1, Ras-converting enzyme, Ras-converting enzyme 1, RCE1, Rce1p, Sc Rce1p, type II CAAX protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.99 Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty)

                3.4.99.B1 RCE1

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Results	in table
3	AA Sequence
4	Application
1	CAS Registry Number
7	Cloned(Commentary)
23	Disease/ Diagnostics
8	General Information
2	IC50 Value
43	Inhibitors
3	Ki Value [mM]
22	KM Value [mM]
18	Localization
1	Metals/Ions
1	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
37	Organism
3	pH Optimum
1	pH Range
1	Posttranslational Modification
39	Protein Variants
1	Reaction
37	Reference
14	Source Tissue
2	Specific Activity [micromol/min/mg]
84	Substrates and Products (Substrate)
53	Synonyms
1	Temperature Optimum [°C]

Disease

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Disease on EC 3.4.99.B1 - RCE1

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinogenesis

Reduced RCE1 expression predicts poor prognosis of colorectal carcinoma.

28615075

Neoplasm Metastasis

Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial-mesenchymal transition induced by the TGF-?1/H-Ras signaling pathway.

31506952

Neoplasms

CaaX converting enzymes.

9559265

Neoplasms

Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.

20696584

Neoplasms

Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial-mesenchymal transition induced by the TGF-?1/H-Ras signaling pathway.

31506952

Neoplasms

Small-Molecule Inhibitors of the Rce1p CaaX Protease.

17942791

Neoplasms

Solid-phase synthesis of a radiolabeled, biotinylated, and farnesylated Ca(1)a(2)X peptide substrate for Ras- and a-mating factor converting enzyme.

11170363

Neoplasms

Studies with recombinant Saccharomyces cerevisiae CaaX prenyl protease Rce1p.

10747800

ste24 endopeptidase deficiency

Targeting RAS-converting enzyme 1 overcomes senescence and improves progeria-like phenotypes of ZMPSTE24 deficiency.

32910507

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