3.4.99.B1: RCE1
This is an abbreviated version!
For detailed information about RCE1, go to the full flat file.
Reaction
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins =
Synonyms
At Rce1p, hRCE1, Hs Rce1p, human Ras-converting enzyme, isoprenylated protein peptidase, RACE, Ras and a-factor converting enzyme, Ras converting enzyme, Ras converting enzyme 1, Ras-converting enzyme, Ras-converting enzyme 1, RCE1, Rce1p, Sc Rce1p, type II CAAX protease
ECTree
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Engineering
Engineering on EC 3.4.99.B1 - RCE1
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C251A
E156A
E156D
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marginal activity, overexpression significantly boosts the activity
E156Q
E157A
F190A
H194A
H196A
H197A
H248A
N252A
additional information
additional information
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RCE1 deficient mice generated, loss of the enzyme results in late embryonic lethality
additional information
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Rce1-deficient cells, uncleaved CaaX accumulates
additional information
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strain yWS163, that lacks the a-factor encoding genes and the CAAX protease genes