3.4.99.B1: RCE1
This is an abbreviated version!
For detailed information about RCE1, go to the full flat file.
Reaction
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins =
Synonyms
At Rce1p, hRCE1, Hs Rce1p, human Ras-converting enzyme, isoprenylated protein peptidase, RACE, Ras and a-factor converting enzyme, Ras converting enzyme, Ras converting enzyme 1, Ras-converting enzyme, Ras-converting enzyme 1, RCE1, Rce1p, Sc Rce1p, type II CAAX protease
ECTree
Advanced search results
Application
Application on EC 3.4.99.B1 - RCE1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
medicine
additional information
-
Rce1-mediated removal of of the last three amino acids from isoprenylated Rho GTPases is required for the proteolytic activity of Yersinia enterocolitca outer protein T in living cells
-
excision of RCE1 from skin carcinoma cell line retards the growth of cells significantly, and this effect was exaggerated by co-treatment with farnesyl-transferase inhibitor
medicine
-
Rce1 knockout mice have a dilated cardiomyopathy, by contrast, liver-specific Rce1 knockout mice appear healthy, endoproteolytic processing of CAAX proteins is essential for cardiac function but less important for the liver
medicine
expression of Rce1 is significantly decreased in hepatocellular carcinoma compared with noncancerous tissues, while H-Ras expression is increased in the tumor. The expression of both is a close association with the differentiation and tumor-node-metastasis stage of the tumor. Rce1 is an independent prognostic indicator. Lower expression of Rce1 facilitates epithelial-mesenchymalctransition and promotes the invasion and metastasis of hepatocellular carcinoma