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3.4.99.B1: RCE1

This is an abbreviated version!
For detailed information about RCE1, go to the full flat file.

Word Map on EC 3.4.99.B1

Reaction

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins =

Synonyms

At Rce1p, hRCE1, Hs Rce1p, human Ras-converting enzyme, isoprenylated protein peptidase, RACE, Ras and a-factor converting enzyme, Ras converting enzyme, Ras converting enzyme 1, Ras-converting enzyme, Ras-converting enzyme 1, RCE1, Rce1p, Sc Rce1p, type II CAAX protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.99 Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty)
                3.4.99.B1 RCE1

Substrates Products

Substrates Products on EC 3.4.99.B1 - RCE1

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-KSKTKC(farnesyl)-K(Dnp)-IM + H2O
?
show the reaction diagram
2-aminobenzoyl-KSKTKC(farnesyl)dinitrophenyldiaminopropionic acid-IM + H2O
2-aminobenzoyl-KSKTKC(farnesyl) + dinitrophenyldiaminopropionic acid-IM
show the reaction diagram
-
34% of activity with KSKTKC(farnesyl)VIM
-
?
2-aminobenzoyl-KSKTKC(farnesyl)lysine-epsilon-dinitrophenyl-IM + H2O
2-aminobenzoyl-KSKTKC(farnesyl) + lysine-epsilon-dinitrophenyl-IM
show the reaction diagram
-
50% of activity with KSKTKC(farnesyl)VIM
-
?
2-aminobenzoyl-KSKTKC(farnesyl)QLIM + H2O
?
show the reaction diagram
-
cleavage of a quenched fluorogenic farnesylated peptide that is based on the C-terminal sequence of the K-Ras4b precursor (2-aminobenzoyl-KSKTKC(farnesyl)-K(Dnp)-IM)
-
-
?
2-aminobenzoyl-KSKTKC(farnesyl)VI + H2O
?
show the reaction diagram
-
-
-
-
?
2-aminobenzoyl-KSKTKC(farnesyl)VI-dinitrophenyldiaminopropionic acid + H2O
2-aminobenzoyl-KSKTKC(farnesyl) + VI-dinitrophenyldiaminopropionic acid
show the reaction diagram
-
4.8% of activity with KSKTKC(farnesyl)VIM
-
?
2-aminobenzoyl-KSKTKC(farnesyl)VI-lysine-epsilon-dinitrophenyl + H2O
2-aminobenzoyl-KSKTKC(farnesyl) + VI-lysine-epsilon-dinitrophenyl
show the reaction diagram
-
25% of activity with KSKTKC(farnesyl)VIM
-
?
2-aminobenzoyl-KSKTKC(farnesyl)VIM + H2O
2-aminobenzoyl-KSKTKC(farnesyl) + VIM
show the reaction diagram
-
-
-
?
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)-dinitrophenyldiaminopropionic acid-IM + H2O
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl) + dinitrophenyldiaminopropionic acid-IM
show the reaction diagram
-
2.5% of activity with KSKTKC(farnesyl)VIM
-
?
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)-VI-dinitrophenyldiaminopropionic acid + H2O
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl) + VI-dinitrophenyldiaminopropionic acid
show the reaction diagram
-
1% of activity with KSKTKC(farnesyl)VIM
-
?
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)lysine-epsilon-dinitrophenyl + H2O
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl) + lysine-epsilon-dinitrophenyl-IM
show the reaction diagram
-
-
-
?
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)VI-lysine-epsilon-dinitrophenyl + H2O
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl) + VI-lysine-epsilon-dinitrophenyl
show the reaction diagram
-
2% of activity with KSKTKC(farnesyl)VIM
-
?
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)VIM + H2O
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl) + VIM
show the reaction diagram
-
35% of activity with KSKTKC(farnesyl)VIM
-
?
a-factor + H2O
fragments of a-factor
show the reaction diagram
-
-
-
?
a-factor derived synthetic farnesylated pentadecapeptide + H2O
?
show the reaction diagram
-
-
-
-
?
a-factor-CaaX + H2O
a-factor-C + aaX
show the reaction diagram
ABZ-KSKTKC(S-farnesyl)-K(Dnp)-IM + H2O
?
show the reaction diagram
-
-
-
?
Abz-L-Lys-L-Ser-L-Lys-L-The-L-Lys-S-[(2E)-4-[(3-benzoylbenzyl)oxy]-3-methylbut-2-en-1-yl]-L-Cys-N6-(3,5-dinitrophenyl)-L-LysL-L-Ile-L-Met + H2O
Abz-L-Lys-L-Ser-L-Lys-L-The-L-Lys-S-[(2E)-4-[(3-benzoylbenzyl)oxy]-3-methylbut-2-en-1-yl]-L-Cys + N6-(3,5-dinitrophenyl)-L-LysL-L-Ile-L-Met
show the reaction diagram
-
i.e. 2-aminobenzoyl-KSKTKC(3-methylbenzophenone prenyl ether)K(dinitrophenyl)IM, an aryl ketone-containing peptide photophore, incorporating a benzophenone-modified isoprenoid, synthesis and structure, mass spectrometrical analysis, overview
mass spectrometrical product analysis
-
?
Abz-L-Lys-L-Ser-L-Lys-L-The-L-Lys-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-Cys-N6-(3,5-dinitrophenyl)-L-LysL-L-Ile-L-Met + H2O
Abz-L-Lys-L-Ser-L-Lys-L-The-L-Lys-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-Cys + N6-(3,5-dinitrophenyl)-L-LysL-L-Ile-L-Met
show the reaction diagram
-
the isoprenylated peptide substrate is derived from the C-terminal sequence of mammalian K-Ras4B, synthesized from 2-aminobenzoyl-KSKTKCK(dinitrophenyl)IM, synthesis and structure, mass spectrometrical analysis, overview
mass spectrometrical product analysis
-
?
CALM + H2O
?
show the reaction diagram
CALQ + H2O
?
show the reaction diagram
CAMQ + H2O
?
show the reaction diagram
CASQ + H2O
?
show the reaction diagram
CSVM + H2O
?
show the reaction diagram
CTLM + H2O
?
show the reaction diagram
CTSM + H2O
?
show the reaction diagram
CTVM + H2O
?
show the reaction diagram
CVIA + H2O
?
show the reaction diagram
dansyl-G(farnesyl)CIIS + H2O
dansyl-G(farnesyl)C + IIS
show the reaction diagram
-
-
-
?
dansyl-GLP(farnesyl)CVVM + H2O
dansyl-GLP(farnesyl)C + VVM
show the reaction diagram
-
-
-
?
dansyl-KTK(farnesyl)CVIM + H2O
dansyl-KTK(farnesyl)C + VIM
show the reaction diagram
-
-
-
?
dansyl-SAK(farnesyl)CVLS + H2O
dansyl-SAK(farnesyl)C + VLS
show the reaction diagram
-
-
-
?
dansyl-WDPA(farnesyl)CVIA + H2O
dansyl-WDPA(farnesyl)C + VIA
show the reaction diagram
-
-
-
?
dansyl-WDPA(geranylgeranyl)CVIA + H2O
dansyl-WDPA(geranylgeranyl)C + VIA
show the reaction diagram
-
-
-
?
farnesyl-Ha-Ras-CaaX + H2O
farnesyl-Ha-Ras-C + aaX
show the reaction diagram
-
-
?
farnesyl-Ki-Ras-CaaX + H2O
farnesyl-Ki-Ras-C + aaX
show the reaction diagram
specific for prenylated proteins containing a C-terminal CaaX motif
-
?
farnesyl-N-Ras-CaaX + H2O
farnesyl-N-Ras-C + aaX
show the reaction diagram
-
-
?
G-gamma1-CaaX + H2O
G-gamma1-C + aaX
show the reaction diagram
-
-
?
geranylgeranyl-Ki-Ras-CaaX + H2O
geranylgeranyl-Ki-Ras-C + aaX
show the reaction diagram
-
-
?
geranylgeranyl-Rab1b-CaaX + H2O
geranylgeranyl-Rab1b-C + aaX
show the reaction diagram
-
-
?
K-Ras(farnesyl)VIM + H2O
K-Ras(farnesyl) + VIM
show the reaction diagram
-
-
-
?
Ki-Ras + H2O
?
show the reaction diagram
-
-
-
?
KSKTKC(farnesyl)VI + H2O
?
show the reaction diagram
-
a better substrate for hRCE1 than a KSKTKC(f)VIM
-
-
?
KSKTKC(farnesyl)VIM + H2O
KSKTKC(farnesyl) + VIM
show the reaction diagram
-
no activity with unfarnesylated peptides
-
?
KWDPA(farnesyl)CVIA + H2O
KWDPA(farnesyl)C + VIA
show the reaction diagram
-
-
-
?
KWDPAC(S-trans,trans-farnesyl)VIA + H2O
KWDPAC(S-trans,trans-farnesyl) + VIA
show the reaction diagram
-
-
-
?
N-acetyl-S-farnesyl-Cys-Val-Ile-Ser + H2O
N-acetyl-S-farnesyl-Cys + Val-Ile-Ser
show the reaction diagram
-
-
-
-
?
N-Boc-S-farnesyl-L-Cys-Val-Ile-Met + H2O
N-Boc-S-farnesyl-L-Cys + Val-Ile-Met
show the reaction diagram
-
-
-
-
?
phosphodiesterase 6 + H2O
?
show the reaction diagram
-
-
-
?
Ras + H2O
fragments of Ras
show the reaction diagram
-
-
-
?
Ras-CaaX + H2O
Ras-C + aaX
show the reaction diagram
-
a stands for aliphatic amino acid, X is any amino acid
-
?
Ras2 + H2O
Ras2-C + aaX
show the reaction diagram
-
a stands for aliphatic amino acid, X is any amino acid
-
?
small GTPase RalA + H2O
?
show the reaction diagram
-
-
-
?
small GTPase RalB + H2O
?
show the reaction diagram
-
-
-
?
YIIKGVFWDPAC(farnesyl)-VIA + H2O
a-factor + ?
show the reaction diagram
-
-
-
-
?
additional information
?
-