3.4.99.B1: RCE1

This is an abbreviated version!
For detailed information about RCE1, go to the full flat file.

Word Map on EC 3.4.99.B1

3.4.99.B1

farnesylated

endoprotease

ste24p

endoproteolysis

pheromone

isoprenylcysteine

mislocalization

ras2p

prenylcysteine

medicine

carboxylmethylation

farnesyltransferase

cvia

ca1a2x

zmpste24

Reaction

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins =

Synonyms

At Rce1p, hRCE1, Hs Rce1p, human Ras-converting enzyme, isoprenylated protein peptidase, RACE, Ras and a-factor converting enzyme, Ras converting enzyme, Ras converting enzyme 1, Ras-converting enzyme, Ras-converting enzyme 1, RCE1, Rce1p, Sc Rce1p, type II CAAX protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.99 Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty)

3.4.99.B1 RCE1

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Results	in table
3	AA Sequence
4	Application
1	CAS Registry Number
7	Cloned(Commentary)
23	Disease/ Diagnostics
8	General Information
2	IC50 Value
43	Inhibitors
3	Ki Value [mM]
22	KM Value [mM]
18	Localization
1	Metals/Ions
1	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
37	Organism
3	pH Optimum
1	pH Range
1	Posttranslational Modification
39	Protein Variants
1	Reaction
37	Reference
14	Source Tissue
2	Specific Activity [micromol/min/mg]
84	Substrates and Products (Substrate)
53	Synonyms
1	Temperature Optimum [°C]

KM Value

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KM Value on EC 3.4.99.B1 - RCE1

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0.003

2-aminobenzoyl-KSKTKC(farnesyl)

Homo sapiens

649307

0.003

2-aminobenzoyl-KSKTKC(farnesyl)lysine-epsilon-dinitrophenyl-IM

Homo sapiens

649307

0.004

2-aminobenzoyl-KSKTKC(farnesyl)VI

Homo sapiens

649307

0.004

2-aminobenzoyl-KSKTKC(farnesyl)VI-dinitrophenyldiaminopropionic acid

Homo sapiens

649307

0.005

2-aminobenzoyl-KSKTKC(farnesyl)VI-lysine-epsilon-dinitrophenyl

Homo sapiens

649307

0.004

2-aminobenzoyl-KSKTKC(farnesyl)VIM

Homo sapiens

649307

0.004

7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)-dinitrophenyldiaminopropionic acid-IM

Homo sapiens

649307

0.005

7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)-VI-dinitrophenyldiaminopropionic acid

Homo sapiens

649307

0.006

7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)lysine-epsilon-dinitrophenyl

Homo sapiens

649307

0.004

7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)VI-lysine-epsilon-dinitrophenyl

Homo sapiens

649307

0.004

7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)VIM

Homo sapiens

649307

0.00144 - 0.00326

a-factor derived synthetic farnesylated pentadecapeptide

4 entries

0.0019

Abz-L-Lys-L-Ser-L-Lys-L-The-L-Lys-S-[(2E)-4-[(3-benzoylbenzyl)oxy]-3-methylbut-2-en-1-yl]-L-Cys-N6-(3,5-dinitrophenyl)-L-LysL-L-Ile-L-Met

Saccharomyces cerevisiae

pH 7.5, 30°C

711466

0.0064

Abz-L-Lys-L-Ser-L-Lys-L-The-L-Lys-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-Cys-N6-(3,5-dinitrophenyl)-L-LysL-L-Ile-L-Met

Saccharomyces cerevisiae

pH 7.5, 30°C

711466

0.002

K-Ras(farnesyl)VIM

Homo sapiens

649307

0.0005

Ki-Ras

Homo sapiens

Q9Y256

farnesylated or geranylgeranylated

651980

0.004

KSKTKC(farnesyl)VIM

Homo sapiens

649307

0.0028

KWDPA(farnesyl)CVIA

Saccharomyces cerevisiae

37°C

653118

0.0057

N-acetyl-S-farnesyl-L-cysteinyl-L-valyl-L-isoleucyl-L-serine

Bos taurus

668781