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Literature summary for 3.4.99.B1 extracted from

  • Hollander, I.; Frommer, E.; Mallon, R.
    Human Ras-Converting Enzyme (hRCE1) Endoproteolytic Activity on K-Ras-Derived Peptides (2000), Anal. Biochem., 286, 129-137.
    View publication on PubMed
Search for more literature for 3.4.99.B1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-Boc-Cys(farnesyl)-methylenamin-VIM-OH i.e. isoprenyl protease inhibitor RPI, 0.000058 mM, 50% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
 K-Ras(farnesyl)VIM
-
 Homo sapiens
0.003
-
 2-aminobenzoyl-KSKTKC(farnesyl)
-
 Homo sapiens
0.003
-
 2-aminobenzoyl-KSKTKC(farnesyl)lysine-epsilon-dinitrophenyl-IM
-
 Homo sapiens
0.004
-
 KSKTKC(farnesyl)VIM
-
 Homo sapiens
0.004
-
 7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)VIM
-
 Homo sapiens
0.004
-
 7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)VI-lysine-epsilon-dinitrophenyl
-
 Homo sapiens
0.004
-
 7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)-dinitrophenyldiaminopropionic acid-IM
-
 Homo sapiens
0.004
-
 2-aminobenzoyl-KSKTKC(farnesyl)VIM
-
 Homo sapiens
0.004
-
 2-aminobenzoyl-KSKTKC(farnesyl)VI
-
 Homo sapiens
0.004
-
 2-aminobenzoyl-KSKTKC(farnesyl)VI-dinitrophenyldiaminopropionic acid
-
 Homo sapiens
0.005
-
 7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)-VI-dinitrophenyldiaminopropionic acid
-
 Homo sapiens
0.005
-
 2-aminobenzoyl-KSKTKC(farnesyl)VI-lysine-epsilon-dinitrophenyl
-
 Homo sapiens
0.006
-
 7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)lysine-epsilon-dinitrophenyl
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
K-Ras(farnesyl)VIM + H2O Homo sapiens
-
 K-Ras(farnesyl) + VIM
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-KSKTKC(farnesyl)dinitrophenyldiaminopropionic acid-IM + H2O 34% of activity with KSKTKC(farnesyl)VIM Homo sapiens 2-aminobenzoyl-KSKTKC(farnesyl) + dinitrophenyldiaminopropionic acid-IM
-
 ?
2-aminobenzoyl-KSKTKC(farnesyl)lysine-epsilon-dinitrophenyl-IM + H2O 50% of activity with KSKTKC(farnesyl)VIM Homo sapiens 2-aminobenzoyl-KSKTKC(farnesyl) + lysine-epsilon-dinitrophenyl-IM
-
 ?
2-aminobenzoyl-KSKTKC(farnesyl)VI + H2O
-
 Homo sapiens ?
-
 ?
2-aminobenzoyl-KSKTKC(farnesyl)VI-dinitrophenyldiaminopropionic acid + H2O 4.8% of activity with KSKTKC(farnesyl)VIM Homo sapiens 2-aminobenzoyl-KSKTKC(farnesyl) + VI-dinitrophenyldiaminopropionic acid
-
 ?
2-aminobenzoyl-KSKTKC(farnesyl)VI-lysine-epsilon-dinitrophenyl + H2O 25% of activity with KSKTKC(farnesyl)VIM Homo sapiens 2-aminobenzoyl-KSKTKC(farnesyl) + VI-lysine-epsilon-dinitrophenyl
-
 ?
2-aminobenzoyl-KSKTKC(farnesyl)VIM + H2O
-
 Homo sapiens 2-aminobenzoyl-KSKTKC(farnesyl) + VIM
-
 ?
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)-dinitrophenyldiaminopropionic acid-IM + H2O 2.5% of activity with KSKTKC(farnesyl)VIM Homo sapiens 7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl) + dinitrophenyldiaminopropionic acid-IM
-
 ?
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)-VI-dinitrophenyldiaminopropionic acid + H2O 1% of activity with KSKTKC(farnesyl)VIM Homo sapiens 7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl) + VI-dinitrophenyldiaminopropionic acid
-
 ?
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)lysine-epsilon-dinitrophenyl + H2O
-
 Homo sapiens 7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl) + lysine-epsilon-dinitrophenyl-IM
-
 ?
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)VI-lysine-epsilon-dinitrophenyl + H2O 2% of activity with KSKTKC(farnesyl)VIM Homo sapiens 7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl) + VI-lysine-epsilon-dinitrophenyl
-
 ?
7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl)VIM + H2O 35% of activity with KSKTKC(farnesyl)VIM Homo sapiens 7-methoxycoumarin-4-acetyl-KSKTKC(farnesyl) + VIM
-
 ?
K-Ras(farnesyl)VIM + H2O
-
 Homo sapiens K-Ras(farnesyl) + VIM
-
 ?
KSKTKC(farnesyl)VIM + H2O no activity with unfarnesylated peptides Homo sapiens KSKTKC(farnesyl) + VIM
-
 ?

Synonyms

Synonyms Comment Organism
human Ras-converting enzyme abbrevation hRCE1 Homo sapiens