3.4.24.B3: matrix metalloproteinase-11
This is an abbreviated version!
For detailed information about matrix metalloproteinase-11, go to the full flat file.
Word Map on EC 3.4.24.B3
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3.4.24.B3
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metalloproteinases
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metastasis
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mmp-2
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timps
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gelatinase
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microperoxidase-11
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metamorphosis
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tadpole
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matrilysin
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menstrual
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medicine
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stromelysin-2
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microperoxidase
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collagenase-3
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pharmacology
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diagnostics
- 3.4.24.B3
- metalloproteinases
- metastasis
- mmp-2
- timps
- gelatinase
-
microperoxidase-11
-
metamorphosis
- tadpole
- matrilysin
-
menstrual
- medicine
- stromelysin-2
-
microperoxidase
- collagenase-3
- pharmacology
- diagnostics
Reaction
proteolytic degradation of proteins =
Synonyms
M10.007, matrix metalloproteinase 11, matrix metalloproteinase-11, matrix metalloproteinase-11/stromelysin-3, matrixin, matrixin 11, MMP stromelysin-3, MMP-11, MMP-11 proteinase, MMP11, More, MP-11, SL-3, ST-3, ST3, stromelysin 3, stromelysin-3
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diagnostics
medicine
pharmacology
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enzyme form with the specific residue A235 is an attractive target for the development of specific inhibitors for use in prevention of cancer progression
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matrix metalloproteinase 11 is a marker for advanced gastric cancer
diagnostics
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MMP-11 is a probable prognostic marker whose expression reflects the stages of tumor differentiation and lymph node metastasis of breast cancer, overview
diagnostics
association between the clinicopathological characteristics and MMP-11 expression in oral squamous cell carcinoma (OSCC) patients, expression of MMP-11 is associated with higher incidence of lymph node metastasis and worse grade of tumor differentiation, overview. The MMP-11 expression in OSCC samples can predict the progression, especially lymph node metastasis, and the survival of OSCC patients in Taiwan
diagnostics
MMP-11 is a biomarker for metastatic breast cancer by immunohistochemical-assisted imaging mass spectrometry
diagnostics
MMP-11 may work as a significant tumor biomarker for early detection of cancer, tumor staging, prognostic analysis, monitoring recurrence during follow-up and also a potential target for immunotherapy against cancer. Prognostic significance of MMP-11 expression in gastric carcinoma. The 5-year survival rates of patients with high expression of both MMP-11 and IGF-1 is significantly lower compared to the patients with low expression levels of both MMP-11 and IGF-1. Expression of MMP-11 and VEGF-C in colorectal adenocarcinoma is believed to be an important index for predicting distant metastases and clinical stages. MMP-11 is not only correlated with advanced-stage and high-grade tumors, but significantly associated with metastasis, especially for lymph node metastasis rather than peritoneal seeding and distant organ metastasis. The expression levels of MMP-11 can be used to identify patients at greater risk for cancer recurrence in breast carcinoma, pancreatic tumors, and colon cancer
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ST-3+/TIMP-2- (stromelysin-3+/matrix metalloproteinase TIMP-2)-phenotype is an adverse prognosticator in esophageal cancer patients
medicine
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ST-3 is capable of enhancing tumourigenesis in breast cancer cell lines
medicine
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MMP11 expression level is correlated with poor prognosis in advanced gastric cancer. MMP11 has great potential to be a new tumor marker in serum
medicine
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MMP11 is a novel broadly expressed tumor associated antigen and a target candidate for cancer immunotherapy. Possible use of murine MMP11 as tumor-associated antigen for vaccination of human cancer patients. MMP11 vaccine induces cell-mediated and antibody immune response and exerts significant antitumoral protection in mice with colon cancer in prophylactic and therapeutic settings
medicine
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MMP11 is a novel broadly expressed tumor associated antigen and a target candidate for cancer immunotherapy. Possible use of murine MMP11 as tumor-associated antigen for vaccination of human cancer patients. MMP11 vaccine induces cell-mediated and antibody immune response and exerts significant antitumoral protection in mice with colon cancer in prophylactic and therapeutic settings
medicine
being selectively expressed in tumor tissues, MMP-11 is a promising target for immunotherapy against tumors
medicine
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MMP11 is a novel broadly expressed tumor associated antigen and a target candidate for cancer immunotherapy. Possible use of murine MMP11 as tumor-associated antigen for vaccination of human cancer patients. MMP11 vaccine induces cell-mediated and antibody immune response and exerts significant antitumoral protection in mice with colon cancer in prophylactic and therapeutic settings
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